Journal ArticleDOI
Phytoestrogens: a review of the present state of research.
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TLDR
The classification of phytoestrogens, methods of identi-cation, their proposed mechanisms of action and botanical sources for phy toestrogens are discussed, including research on bene⬁ts and risks.Abstract:
Phytoestrogens are a diverse group of plant-derived compounds that structurally or functionally mimic mammalian estrogens and show potential benefits for human health. The number of articles published on phytoestrogens has risen dramatically in the past couple decades. Further research continues to demonstrate the biological complexity of phytoestrogens, which belong to several different chemical classes and act through diverse mechanisms. This paper discusses the classification of phytoestrogens, methods of identification, their proposed mechanisms of action and botanical sources for phytoestrogens. The effects of phytoestrogens on breast and prostate cancers, cardiovascular disease, menopausal symptoms and osteoporosis will also be examined including research on benefits and risks.read more
Citations
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Journal ArticleDOI
Estrogen Receptors: How Do They Signal and What Are Their Targets
Nina Heldring,Ashley C. W. Pike,Sandra Andersson,Jason Matthews,Guojun Cheng,Johan Hartman,Michel Tujague,Anders Ström,Eckardt Treuter,Margaret Warner,Jan-Åke Gustafsson +10 more
TL;DR: This review focuses on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen signaling.
Journal ArticleDOI
Exogenous antioxidants--Double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses.
Jaouad Bouayed,Torsten Bohn +1 more
TL;DR: The double-edged effects of dietary originating antioxidants with a focus on the most abundant compounds, especially polyphenols, vitamin C, vitamin E and carotenoids are examined, highlighting that antioxidants at physiological doses are generally safe, exhibiting interesting health beneficial effects.
Journal ArticleDOI
The G-protein-coupled estrogen receptor GPER in health and disease
TL;DR: The physiological roles of GPER are highlighted in the reproductive, nervous, endocrine, immune and cardiovascular systems, as well as its pathological roles in a diverse array of disorders including cancer, for which GPER is emerging as a novel therapeutic target and prognostic indicator.
Journal ArticleDOI
Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30
Eric R. Prossnitz,Jeffrey B. Arterburn,Jeffrey B. Arterburn,Harriet O. Smith,Tudor I. Oprea,Larry A. Sklar,Helen J. Hathaway +6 more
TL;DR: An overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and the relationship of G PR30 with classical estrogen receptors is provided.
Journal ArticleDOI
Physiological and molecular approaches to improve drought resistance in soybean.
TL;DR: The objective of this review is to consolidate the current knowledge of physiology, molecular breeding and functional genomics which may be influential in integrating breeding and genetic engineering approaches for drought resistance in soybean.
References
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Journal ArticleDOI
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial
Jacques E. Rossouw,Garnet L. Anderson,Ross L. Prentice,Andrea Z. LaCroix,Charles Kooperberg,Marcia L. Stefanick,Rebecca D. Jackson,Shirley A.A. Beresford,Barbara V. Howard,Karen C. Johnson,Jane Morley Kotchen,Judith K. Ockene +11 more
TL;DR: Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD.
Journal ArticleDOI
Trends in Alternative Medicine Use in the United States, 1990-1997 Results of a Follow-up National Survey
David Eisenberg,Roger B. Davis,Susan L. Ettner,Scott Appel,Sonja Wilkey,Maria I. Van Rompay,Ronald C. Kessler +6 more
TL;DR: Alternative medicine use and expenditures increased substantially between 1990 and 1997, attributable primarily to an increase in the proportion of the population seeking alternative therapies, rather than increased visits per patient.
Journal ArticleDOI
Cloning of a novel receptor expressed in rat prostate and ovary.
TL;DR: It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
Journal ArticleDOI
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
George G.J.M. Kuiper,Bo Carlsson,Kaj Grandien,Eva Enmark,Johan Häggblad,Stefan K. Nilsson,Jan-Åke Gustafsson +6 more
TL;DR: The messenger RNA expression of both ER subtypes in rat tissues by RT-PCR is investigated and the ligand binding specificity of the ER sub types is compared, revealing a single binding component for 16β-estradiol with high affinity.
Journal ArticleDOI
Unconventional medicine in the United States. Prevalence, costs, and patterns of use.
David Eisenberg,Ronald C. Kessler,Cindy Foster,Frances E. Norlock,David R. Calkins,Thomas L. Delbanco +5 more
TL;DR: The frequency of use of unconventional therapy in the United States is far higher than previously reported and expenditure associated with use in 1990 amounted to approximately $13.7 billion, comparable to the $12.8 billion spent out of pocket annually for all hospitalizations in theUnited States.