Pillar[5]arene-based amphiphilic supramolecular brush copolymer: fabrication, controllable self-assembly and application in self-imaging targeted drug delivery.
Guocan Yu,Run Zhao,Dan Wu,Fuwu Zhang,Li Shao,Jiong Zhou,Jie Yang,Guping Tang,Xiaoyuan Chen,Feihe Huang +9 more
TLDR
In vitro studies demonstrated that the loading of DOX by this supramolecular nanomaterial exhibited selective cytotoxicity towards cancer cells over normal cells, and in vivo experiments confirmed that the DOX-loaded SNPs possess excellent antitumor efficacy with negligible systemic toxicity.About:
This article is published in Polymer Chemistry.The article was published on 2016-10-11 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Targeted drug delivery & Drug delivery.read more
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Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future
Jiong Zhou,Guocan Yu,Feihe Huang +2 more
TL;DR: A review summarizing the progress of supramolecular chemotherapy in cancer treatment based on host-guest recognition and guidance on the design of new targeting supramolescular chemotherapy combining diagnostic and therapeutic functions is presented.
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Functional Supramolecular Polymeric Networks: The Marriage of Covalent Polymers and Macrocycle-Based Host-Guest Interactions
Danyu Xia,Pi Wang,Xiaofan Ji,Niveen M. Khashab,Jonathan L. Sessler,Jonathan L. Sessler,Feihe Huang,Feihe Huang +7 more
TL;DR: This Review summarizes advances made in the area of functional SPNs, with a focus on original literature reports appearing in the past five years, and is organized according to the key macrocycle-based host-guest interactions used to produce various SPNs.
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Supramolecular Assembly-Induced Emission Enhancement for Efficient Mercury(II) Detection and Removal
TL;DR: The newly developed supramolecular polymer system combines the inherent rigid and spacious cavity of novel extended-pillarene host with the AIE characteristics of TPE-based guest, suggesting a great potential in the treatment of heavy metal pollution and environmental sustainability.
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Aggregation‐enhanced theranostics: AIE sparkles in biomedical field
Miaomiao Kang,Zhijun Zhang,Nan Song,Meng Li,Panpan Sun,Xiaohui Chen,Dong Wang,Ben Zhong Tang +7 more
TL;DR: This review highlights the tremendous aggregation‐enhanced superiorities of AIE luminogens (AIEgens) in disease theranostics mainly involving diagnostic imaging (fluorescence and room temperature phosphorescence), therapeutic intervention (photodynamic therapy), and feasibility in construction of multi‐modality theranostic based on the experimental measurements and theoretical simulations.
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Pillararene-based self-assembled amphiphiles
TL;DR: This review provides fundamental findings on the construction of PSAs, and foresees future research directions in this rapidly developing area.
References
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Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole
Jingdong Luo,Zhiliang Xie,Jacky W. Y. Lam,Lin Cheng,Haiying Chen,Chengfeng Qiu,Hoi Sing Kwok,Xiaowei Zhan,Yunqi Liu,Daoben Zhu,Ben Zhong Tang +10 more
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TL;DR: In this critical review, recent progress in the area ofAIE research is summarized and typical examples of AIE systems are discussed, from which their structure-property relationships are derived.
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Emerging applications of stimuli-responsive polymer materials
Martien A. Cohen Stuart,Wilhelm T. S. Huck,Jan Genzer,Marcus Müller,Christopher K. Ober,Manfred Stamm,Gleb B. Sukhorukov,Igal Szleifer,Vladimir V. Tsukruk,Marek W. Urban,Françoise M. Winnik,Stefan Zauscher,Igor Luzinov,Sergiy Minko +13 more
TL;DR: This work reviews recent advances and challenges in the developments towards applications of stimuli-responsive polymeric materials that are self-assembled from nanostructured building blocks and provides a critical outline of emerging developments.
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Stimuli-responsive nanocarriers for drug delivery
TL;DR: Recent advances in the design of nanoscale stimuli-responsive systems that are able to control drug biodistribution in response to specific stimuli, either exogenous (variations in temperature, magnetic field, ultrasound intensity, light or electric pulses) or endogenous (changes in pH, enzyme concentration or redox gradients).
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Strategies in the design of nanoparticles for therapeutic applications
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