Journal ArticleDOI
Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates melatonin synthesis from rat pineal gland.
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Kinetic analysis of melatonin release indicated that PACAP acts postsynaptically via receptor activation, which is similar to that of isoproterenol.About:
This article is published in Brain Research.The article was published on 1993-02-12. It has received 74 citations till now. The article focuses on the topics: Pituitary adenylate cyclase-activating peptide & Pinealocyte.read more
Citations
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Journal Article
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: From Structure to Functions
TL;DR: The current knowledge concerning the multiple actions of PACAP in the central nervous system and in various peripheral organs including the endocrine glands, the airways, and the cardiovascular and immune systems are reviewed, as well as the different effects ofPACAP on a number of tumor cell types.
Journal ArticleDOI
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
David Vaudry,Anthony Falluel-Morel,Steve Bourgault,Magali Basille,Delphine Burel,Olivier Wurtz,Alain Fournier,Billy K. C. Chow,Hitoshi Hashimoto,Ludovic Galas,Hubert Vaudry +10 more
TL;DR: The present report reviews the current knowledge concerning the pleiotropic actions of PACAP and discusses its possible use for future therapeutic applications.
Journal ArticleDOI
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
TL;DR: The aim of this review is to gather together early and recent data on the effects of the nonadrenergic transmitters on modulation of melatonin synthesis, which reveals the variety of inputs that can be integrated by the pineal gland; what elements are crucial to deliver the very precise timing information to the organism.
Journal ArticleDOI
Type I receptors for PACAP (a neuropeptide even more important than VIP
TL;DR: The mapping of the afferentation and efferentation ofPACAP systems are progressively delineated, including a search for the colocalization with other neurotransmitters, and the physiological roles of PACAP as neurotransmitter and/or neuromodulator are limited.
BookDOI
[Pituitary adenylate cyclase-activating polypeptide].
TL;DR: The bronchodilatator and vasorelaxant effects of PACAP, as well as the antiproliferative and neuroprotective actions of the peptide, make it a valuable target for new drug development.
References
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Journal ArticleDOI
Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells
Atsuro Miyata,Akira Arimura,Raymond R. Dahl,Naoto Minamino,Akira Uehara,Lun Jiang,M.D. Culler,David H. Coy +7 more
TL;DR: A novel neuropeptide which stimulates adenylate cyclase in rat anterior pituitary cell cultures was isolated from ovine hypothalamic tissues and increased release of growth hormone, prolactin, corticotropin and luteinizing hormone from superfused rat pituitaries at as small a dose as 10(-10)M) or 10(-9)M (LH).
Journal ArticleDOI
Isolation of a neuropeptide corresponding to the N-terminal 27 residues of the pituitary adenylate cyclase activating polypeptide with 38 residues (PACAP38).
Atsuro Miyata,Lun Jiang,Raymond D. Dahl,Chieko Kitada,Kazuki Kubo,Masahiko Fujino,Naoto Minamino,Akira Arimura +7 more
TL;DR: Synthetic PACAP27 which shows a considerable homology with vasoactive intestinal polypeptide (VIP) demonstrated a similar vasodepressor activity as VIP, but the adenylate cyclase stimulating activity was about 1000 times greater than VIP.
Journal ArticleDOI
The pineal gland.
TL;DR: It is not yet certain what pbysiobgical~dependontbepineal clock for cues is, but there is evidence at band ~ggest that the pineal participates in sanewayintbequlationoftbegonads,orsexglands.
Journal Article
The pineal gland.
TL;DR: The pineal body has been shown to be an intricate and sensitive biological clock, converting cyclic nervous activity generated by light in the environment into endocrine-infonnat&n.
Journal ArticleDOI
Pituitary adenylate cyclase activating polypeptide (PACAP): discovery and current status of research
TL;DR: Immunohistochemical study indicated that PACAP containing neural fibers are present throughout the brain, including both internal and external zones of the median eminence, in the hypothalamus and the supraoptic nucleus in various species.