Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Wael K. Al-Delaimy,Nadia Slimani,Pamela Ferrari,Timothy J. Key,Elizabeth A Spencer,Ingegerd Johansson,G Johansson,Irene Mattisson,E. Wirfält,Sabina Sieri,A. Agudo,Egidio Celentano,Domenico Palli,Carlotta Sacerdote,R. Tumino,Miren Dorronsoro,Marga C. Ocké,H. B. Bueno-De-Mesquita,Kim Overvad,Kim Overvad,Ma Dolores Chirlaque,Antonia Trichopoulou,Androniki Naska,Anne Tjønneland,A. Olsen,Eiliv Lund,Guri Skeie,Eva Ardanaz,Emmanuelle Kesse,M. C. Boutron-Ruault,M. C. Boutron-Ruault,Françoise Clavel-Chapelon,Sheila Bingham,Ailsa A Welch,Carmen Martinez-Garcia,Gabriele Nagel,J. Linseisen,J. R. Quirós,P. H. M. Peeters,C. H. van Gils,Heiner Boeing,A. L. Van Kappel,J.-P. Steghens,Elio Riboli +43 more
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TLDR
Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in the authors' multicentre European study.Abstract:
Objective: The aim in this study was to assess the association between individual plasma carotenoid levels (alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, lutein, zeaxanthin) and fruit and vegetable intakes recorded by a calibrated food questionnaire (FQ) and 24- h dietary recall records (24HDR) in nine different European countries with diverse populations and widely varying intakes of plant foods. Design: A stratified random subsample of 3089 men and women from nine countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had provided blood samples and dietary and other lifestyle information between 1992 and 2000, were included. Results: beta-Cryptoxanthin was most strongly correlated with total fruits (FQ r = 0.52, 24HDR r = 0.39), lycopene with tomato and tomato products (FQ r = 0.38, 24HDR r = 0.25), and alpha-carotene with intake of root vegetables (r = 0.39) and of total carrots (r = 0.38) for FQ only. Based on diet measured by FQ and adjusting for possible confounding by body mass index (BMI), age, gender, smoking status, alcohol intake, and energy intake, the strongest predictors of individual plasma carotenoid levels were fruits (R-partial(2) = 17.2%) for beta-cryptoxanthin, total carrots (R-partial(2) = 13.4%) and root vegetables (R-partial(2) = 13.3%) for alpha-carotene, and tomato products (R-partial(2) = 13.8%) for lycopene. For 24HDR, the highest R-partial(2) was for fruits in relation to beta-cryptoxanthin (7.9%). Conclusions: Intakes of specific fruits and vegetables as measured by food questionnaires are good predictors of certain individual plasma carotenoid levels in our multicentre European study. At individual subject levels, FQ measurements of fruits, root vegetables and carrots, and tomato products are, respectively, good predictors of beta-cryptoxanthin, alpha-carotene, and lycopene in plasma.read more
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The food metabolome: a window over dietary exposure
Augustin Scalbert,Lorraine Brennan,Claudine Manach,Cristina Andres-Lacueva,Lars O. Dragsted,John Draper,Stephen M. Rappaport,Justin J. J. van der Hooft,David S. Wishart +8 more
TL;DR: Key recommendations made during the workshop included more coordination of efforts; development of new databases, software tools, and chemical libraries for the food metabolome; and shared repositories of metabolomic data.
Journal ArticleDOI
The EPIC nutrient database project (ENDB) : a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study.
Nadia Slimani,G. Deharveng,Ian Unwin,D. A. T. Southgate,Jérôme Vignat,Guri Skeie,Simonetta Salvini,Maria Parpinel,A Møller,J. Ireland,Wulf Becker,Andreu Farran,Susanne Westenbrink,Effie Vasilopoulou,J Unwin,A Borgejordet,Sabine Rohrmann,S. Church,Patrizia Gnagnarella,Corinne Casagrande,M. M. E. van Bakel,M Niravong,M. C. Boutron-Ruault,Connie Stripp,Anne Tjønneland,Antonia Trichopoulou,K Georga,Sara Nilsson,I Mattisson,Jennifer Ray,H. Boeing,Marga C. Ocké,P. H. M. Peeters,Paula Jakszyn,Pilar Amiano,Dagrun Engeset,Eiliv Lund,M. Santucci de Magistris,Carlotta Sacerdote,Ailsa A Welch,Sheila Bingham,A F Subar,Elio Riboli +42 more
TL;DR: The ad hoc methodological concepts and procedures developed to improve the comparability of Nutrient databases (NDBs) across the 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) provide a useful tool for nutritional research as well as end-user recommendations to improve NDBs in the future.
Journal ArticleDOI
Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials
Nathalie Druesne-Pecollo,Paule Latino-Martel,Teresa Norat,Emilie Barrandon,Sandrine Bertrais,Pilar Galan,Serge Hercberg +6 more
TL;DR: The evidence that nutritional prevention of cancer through beta‐carotene supplementation should not be recommended is added, as it was associated with increased risk not only of lung cancer but also of gastric cancer at doses of 20–30 mg day−1, in smokers and asbestos workers.
Journal ArticleDOI
Metabolic profiling strategy for discovery of nutritional biomarkers: proline betaine as a marker of citrus consumption.
Silke S. Heinzmann,Ian J. Brown,Queenie Chan,Magda Bictash,Marc-Emmanuel Dumas,Sunil Kochhar,Jeremiah Stamler,Elaine Holmes,Paul Elliott,Paul Elliott,Jeremy K. Nicholson,Jeremy K. Nicholson +11 more
TL;DR: A strategy for food biomarker discovery, which combined nutritional intervention with metabolic phenotyping and biomarker validation in a large-scale epidemiologic study, identified proline betaine as a putative biomarker of citrus consumption.
Journal ArticleDOI
Plasma phospholipid fatty acid profiles and their association with food intakes: results from a cross-sectional study within the European Prospective Investigation into Cancer and Nutrition
Mitra Saadatian-Elahi,Nadia Slimani,Veronique Chajes,Mazda Jenab,Joëlle Goudable,Carine Biessy,Pietro Ferrari,Graham Byrnes,Philippe Autier,Petra H.M. Peeters,Marga C. Ocké,Bas Bueno de Mesquita,Ingegerd Johansson,Göran Hallmans,Jonas Manjer,Elisabet Wirfält,Carlos A. González,Carmen Navarro,Carmen Enid Martínez,Pilar Amiano,Laudina Rodríguez Suárez,Eva Ardanaz,Anne Tjønneland,Jytte Halkjær,Kim Overvad,Marianne Uhre Jakobsen,Franco Berrino,Valeria Pala,Domenico Palli,Rosario Tumino,Paolo Vineis,Maria Santucci de Magistris,E. A. Spencer,Francesca L. Crowe,Sheila Bingham,Kay-Tee Khaw,Jakob Linseisen,Sabine Rohrmann,Heiner Boeing,Ute Noethlings,Karina Standahl Olsen,Guri Skeie,Eiliv Lund,Antonia Trichopoulou,Erifili Oustoglou,F. Clavel-Chapelon,Elio Riboli +46 more
TL;DR: The findings indicate that specific plasma phospholipid fatty acids are suitable biomarkers of some food intakes in the EPIC Study and suggest complex interactions between alcohol intake and fatty acid metabolism, which warrants further attention in epidemiologic studies relating dietary fatty acids to alcohol-related cancers and other chronic diseases.
References
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Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Book
Applied Regression Analysis and Other Multivariable Methods
TL;DR: In this article, the authors compare two straight line regression models and conclude that the Straight Line Regression Equation does not measure the strength of the Straight-line Relationship, but instead is a measure of the relationship between two straight lines.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.
Journal ArticleDOI
Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
TL;DR: It would appear that major public health benefits could be achieved by substantially increasing consumption of fruit and vegetable consumption, and in particular in cancers of the esophagus, oral cavity, and larynx, for which 28 of 29 studies were significant.
Book
Modern Nutrition in Health and Disease
TL;DR: The fourth edition of Modern Nutrition in Health and Disease follows the organization established in previous volumes, i.e., "Normal Nutrition," "Nutrition in Disease," and "Nut Nutrition in Periods of Physiologic Stress" Each of the 43 chapters is, in essence, a review of a given topic, with primary emphasis on nutritional principles rather than dietetics as mentioned in this paper.
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