Journal ArticleDOI
Plasma neutrophil gelatinase-associated lipocalin levels in acute myocardial infarction and stable coronary artery disease
Asife Sahinarslan,Sinan Altan Kocaman,Duygu Bas,Ahmet Akyel,Ugur Ercin,Ozlem Zengin,Timur Timurkaynak +6 more
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The plasma level of NGAL is higher in patients with AMI compared with the patients with stable CAD, which may suggest an active pathophysiological role for NGAL in development of acute coronary events.Abstract:
Introduction Inflammation and polymorphonuclear neutrophils are shown to be important in the pathogenesis of acute myocardial infarction (AMI). Neutrophil gelatinaseassociated lipocalin (NGAL) is secreted from neutrophils and may increase the proteolytic activity within the atherosclerotic plaque. We aimed to investigate whether the plasma levels of NGAL are higher in patients with AMI compared with stable coronary artery disease (CAD). Methods The study population consisted of 128 eligible patients who underwent coronary angiography with the clinical diagnosis of CAD. Of the 128 patients included in the study, the diagnosis was ST-segment elevation myocardial infarction (STEMI) in 53 patients, non-STelevation myocardial infarction (NSTEMI) in 38 patients and stable CAD in 37 patients. Plasma level of NGAL was measured in all patients with enzyme-linked immunosorbent assay method. We compared the plasma NGAL levels among the groups. Results We found higher plasma NGAL levels in patients with AMI compared with the patients with stable CAD (146±23 vs. 101±53ng/ml, P<0.001). The plasma NGAL levels between the subgroups of AMI were similar (145±23.9 vs. 145±23.4ng/ml, P=not significant). In multivariate analysis, the independent factors related to AMI were current smoking (P=0.024), extent and severity of coronary atherosclerosis (P=0.030), and NGAL levels. The plasma NGAL level was independently related to the existence of AMI (odds ratio: 1.045, 95% confidence interval: 1.019–1.072, P=0.001). In patients with plasma NGAL level above 127ng/ml, we observed a 12 times higher incidence of AMI (odds ratio: 12.2, 95% confidence interval: 2.3–64, P=0.003). Conclusion The plasma level of NGAL is higher in patients with AMI compared with the patients with stable CAD. This finding may suggest an active pathophysiological role for NGAL in development of acute coronary events. Coron Artery Dis 00:000–000 c 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. Coronary Artery Disease 2011, 00:000–000read more
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The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer
TL;DR: The expression, structure, regulation and biological role of NGAL is examined and its potential as a novel diagnostic and prognostic marker in both benign and malignant human diseases is critically assessed.
Journal ArticleDOI
Identification of IGFBP-7 by urinary proteomics as a novel prognostic marker in early acute kidney injury
Fabienne Aregger,Fabienne Aregger,Dominik E. Uehlinger,Janusz Witowski,René A. Brunisholz,Peter Hunziker,Felix J. Frey,Achim Jörres +7 more
TL;DR: IGFBP-7 was a more accurate predictor of renal outcome than NGAL and is a novel prognostic urinary marker that warrants further investigation.
Journal ArticleDOI
Prognostic utility of neutrophil gelatinase-associated lipocalin in predicting mortality and cardiovascular events in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention
Søren Lindberg,Sune H. Pedersen,Rasmus Mogelvang,Jan Skov Jensen,Allan Flyvbjerg,Allan Flyvbjerg,Søren Galatius,Nils E. Magnusson,Nils E. Magnusson +8 more
TL;DR: High plasma NGAL independently predicts all-cause mortality and MACE in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention.
Journal ArticleDOI
More than a simple biomarker: the role of NGAL in cardiovascular and renal diseases
TL;DR: In the present review, current knowledge concerning the involvement of NGAL in cardiovascular and renal diseases is summarized and the various mechanisms underlying its pathological implications are discussed.
Journal ArticleDOI
Neutrophil Gelatinase-Associated Lipocalin (NGAL) is Associated with Symptomatic Carotid Atherosclerosis and Drives Pro-inflammatory State In Vitro
Wolf Eilenberg,Stefan Stojkovic,Aleksandra Piechota-Polanczyk,Christoph Kaun,Sabine Rauscher,Marion Gröger,Markus Klinger,Johann Wojta,Christoph Neumayer,Ihor Huk,Svitlana Demyanets +10 more
TL;DR: By induction of pro-inflammatory mediators in human macrophages, smooth muscle cells and endothelial cells, NGAL, which is predominantly expressed in atherosclerotic plaques of symptomatic patients, could be involved in creating the local and systemic pro- inflammatory environment characteristic for atherosclerosis.
References
More filters
Journal ArticleDOI
Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events
TL;DR: The data suggest that the C-reactive protein level is a stronger predictor of cardiovascular events than the LDL cholesterol level and that it adds prognostic information to that conveyed by the Framingham risk score.
Journal ArticleDOI
A More Meaningful Scoring System for Determining the Severity of Coronary Heart Disease
Journal ArticleDOI
Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase
TL;DR: A 25-kDa protein was found to be associated with purified human neutrophil gelatinase, which showed a high degree of similarity with the deduced sequences of rat alpha 2-microglobulin-related protein and the mouse protein 24p3, and is a new member of the lipocalin family.
Journal ArticleDOI
Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
Stephan Baldus,Christopher Heeschen,Thomas Meinertz,Andreas M. Zeiher,Jason P. Eiserich,Thomas Münzel,Maarten L. Simoons,Christian W. Hamm +7 more
TL;DR: Given its proinflammatory properties, MPO may serve as both a marker and mediator of vascular inflammation and further points toward the significance of PMN activation in the pathophysiology of ACS.
Journal ArticleDOI
Plasma Concentrations and Genetic Variation of Matrix Metalloproteinase 9 and Prognosis of Patients With Cardiovascular Disease
Stefan Blankenberg,Hans J. Rupprecht,Odette Poirier,Christoph Bickel,Marek Smieja,Gerd Hafner,Jürgen Meyer,François Cambien,Laurence Tiret +8 more
TL;DR: Plasma MMP-9 concentration was identified as a novel predictor of CV mortality in patients with coronary artery disease and whether it provides independent prognostic information compared with other inflammatory markers will have to be additionally assessed.