Plasmodium falciparum and Helminth Coinfection in a Semiurban Population of Pregnant Women in Uganda
Stephen D. Hillier,Mark Booth,Lawrence Muhangi,Peter Nkurunziza,Macklyn Khihembo,Muhammad Kakande,Moses Sewankambo,Robert Kizindo,Moses Kizza,Moses Muwanga,Alison M. Elliott,Alison M. Elliott +11 more
TLDR
Hookworm-P.Abstract:
Introduction
Helminth infections and malaria are widespread in the tropics. Recent studies suggest helminth infections may increase susceptibility to malaria. If confirmed, this could be particularly important during pregnancy-induced immunosuppression.read more
Citations
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Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections
TL;DR: Strategies to improve child health should integrate the possible clinical implications of in-utero exposure to chronic maternal infections.
Journal ArticleDOI
Do antenatal parasite infections devalue childhood vaccination
A. Desiree LaBeaud,A. Desiree LaBeaud,Indu Malhotra,Maria J. King,Christopher L. King,Charles H. King +5 more
TL;DR: A review of efficacy and effectiveness studies of vaccination among individuals with chronic parasitic infections was conducted, using PUBMED database searches and analysis of data from the authors' published and unpublished studies to suggest that antiparasite therapy can improve the effectiveness of several human vaccines.
Journal ArticleDOI
Mansonella perstans filariasis in Africa.
TL;DR: There is an urgent need for more research on this widespread but greatly neglected infection in order to properly assess its public health significance and as a background for identifying and recommending optimal means and strategies for treatment and control.
Journal ArticleDOI
Polyparasitism and its impact on the immune system.
Taniawati Supali,Jaco J. Verweij,Aprilianto E. Wiria,Aprilianto E. Wiria,Yenny Djuardi,Yenny Djuardi,Firdaus Hamid,Firdaus Hamid,Maria M. M. Kaisar,Maria M. M. Kaisar,Linda J. Wammes,Linda J. Wammes,Lisette van Lieshout,Adrian J. F. Luty,Erliyani Sartono,Maria Yazdanbakhsh +15 more
TL;DR: What the authors know as well as the gaps in their knowledge of polyparasitism are discussed, which mean that whether such interactions affect resistance, susceptibility or clinical outcome, needs to be addressed in well-designed studies of sufficient power.
References
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Journal Article
A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni.
Journal ArticleDOI
Helminth parasites – masters of regulation
Rick M. Maizels,Adam Balic,Natalia Gomez-Escobar,Meera G. Nair,Matthew D. Taylor,Judith E. Allen +5 more
TL;DR: It is hypothesized that parasites have evolved specific molecular strategies to induce this conducive landscape, and the foremost candidate immunomodulators released by helminths are reviewed, including cytokine homologs, protease inhibitors, and an intriguing set of novel products implicated in immune suppression.
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Mother's little helpers: mechanisms of maternal-fetal tolerance
John Trowsdale,Alexander G. Betz +1 more
TL;DR: During pregnancy, the semi-allogeneic fetus is protected from assault by the maternal immune system over an extended period of time, and the mother's immune system seems to recognize the fetus as 'temporary self'.
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Multiparasite communities in animals and humans: frequency, structure and pathogenic significance.
Trevor N. Petney,Ross H. Andrews +1 more
TL;DR: This review summarises aspects of current knowledge on the frequency of multiparasite infections, the factors which influence them, and their pathogenic significance.
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Progesterone and the immunology of pregnancy
TL;DR: The foetal-placental unit is a semi-allograft and the immunological recognition of pregnancy, together with the subsequent response of the maternal immune system, is necessary for a successful pregnancy.