Journal ArticleDOI
Polymeric worm micelles as nano-carriers for drug delivery.
TLDR
W worm micelles as blends of degradable polylactic acid and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media, suggesting a new class of hydrophobic drug nano-carriers that are capable of tissue permeation as well as controlled release.Abstract:
Nanoscale carriers of active compounds, especially drugs, need not be spherical in shape. Worm micelles as blends of degradable polylactic acid (PLA) and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media. The loading capacity of a typical hydrophobic drug, Triamterene, and the release of hydrophobic dyes were evaluated together with morphological changes of the micelles. Degradation of PLA by hydrolysis led to the self-shortening of worms and a clear transition towards spherical micelles, correlating with the release of hydrophobic dyes. Perhaps equally important for application is the flexibility of worm micelles, which we show allows them to penetrate nanoporous gels where 100 nm sized vesicles cannot enter. Such gels have served as tissue models, and so the results here collectively suggest a new class of hydrophobic drug nano-carriers that are capable of tissue permeation as well as controlled release.read more
Citations
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Micelles of Different Morphologies—Advantages of Worm-like Filomicelles of PEO-PCL in Paclitaxel Delivery
TL;DR: PEO–PCL based worm-like filomicelles appear to be promising pharmaceutical nanocarriers with improved solubilization efficiency and comparable stability to spherical micelles, as well as better safety and efficacy in vitro compared to the prevalent Cremophor® EL TAX formulation.
Journal ArticleDOI
Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles
Yan Geng,Dennis E. Discher +1 more
TL;DR: The first preparation of giant and flexible worm micelles self-assembled from degradable copolymer poly(ethylene oxide)-block-polycaprolactone is reported, with distinct mechanism and kinetics from that which occurs in bulk material.
Journal ArticleDOI
Self-Assembled Polystyrene-block-poly(ethylene oxide) Micelle Morphologies in Solution
TL;DR: In this paper, the self-assembly behavior of an amphiphilic diblock copolymer, polystyrene-block-poly(ethylene oxide) (PS-b-PEO), in N,N-dimethylformamide (DMF)/water and DMF/acetonitrile was investigated.
Journal ArticleDOI
Spontaneous Generation of Amphiphilic Block Copolymer Micelles with Multiple Morphologies through Interfacial Instabilities
Jintao Zhu,Ryan C. Hayward +1 more
TL;DR: This method is shown to be general to polymers with several different hydrophobic blocks: poly(1,4-butadiene), poly(-caprolactone), and poly(methyl methacrylate).
Journal ArticleDOI
Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery.
TL;DR: This review highlights the promising carrier designs that may achieve an optimal balance of DNA protection and release and discusses the imaging techniques and three-dimensional in vitro models that can help study these two barriers in the non-viral gene transfer process.
References
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Journal ArticleDOI
Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
Journal ArticleDOI
Polymeric micelles - a new generation of colloidal drug carriers.
TL;DR: This review examines the chemical nature of polymeric micelles as well as the methods used to characterize them with regard to drug delivery and potential medical applications, especially in cancer chemotherapy, are described and discussed.
Journal ArticleDOI
On the Origins of Morphological Complexity in Block Copolymer Surfactants
Sumeet Jain,Frank S. Bates +1 more
TL;DR: Experiments with poly(1,2-butadiene-b-ethylene oxide) diblock copolymers are described, which form Y-junctions and three-dimensional networks in water at weight fractions of PEO intermediate to those associated with vesicle and wormlike micelle morphologies.
Journal ArticleDOI
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed,Dennis E. Discher +1 more
TL;DR: With all compositions, in both 100 nm and giant vesicles, the average release time reflects a highly quantized process in which any given vesicle is either intact and retains its encapsulant, or is porated and slowly disintegrates.
Journal ArticleDOI
Giant Wormlike Rubber Micelles
TL;DR: A low molecular weight poly(ethyleneoxide)-poly(butadiene) (PEO-PB) diblock copolymer containing 50 weight percent PEO forms gigantic wormlike micelles at low concentrations (<5 percent by weight) in water.
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