Book ChapterDOI
Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline During Normal and Pathological Brain Aging.
S. Asha Devi,Anudita Chamoli +1 more
TLDR
A combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.Abstract:
Research in animals and humans has indicated that polyphenols can delay the age-related decline in learning, memory and neurodegenerative diseases. Among the polyphenols, berry phenolics have extensive beneficial effects because of their antioxidant and anti-inflammatory properties. Long-term consumption of grapes results in accumulation of polyphenols in the brain, which modulates cell-signalling pathways and neutralises the redox imbalance in the aging brain. Here we review the in vivo and in vitro evidence for considering grape-derived polyphenolics, the flavonoids- catechins, epicatechin, anthocyanidin, and quercetin, and non-flavonoids-gallic acid and resveratrol, as effective dietary sources to facilitate cognition in adults and lessen the decline in the old and pathogenic states, Alzheimer's and Parkinson's disease. Furthermore, a combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.read more
Citations
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SIRT1 in Neurodevelopment and Brain Senescence
TL;DR: Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals.
Journal ArticleDOI
Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue.
TL;DR: In this article, a phytosomal formulation (in olive pomace oil) of the natural flavonoid luteolin was used to mitigate brain fog in patients undergoing or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS).
Journal ArticleDOI
Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders?
Mireille Koudoufio,Yves Desjardins,Francis Feldman,Francis Feldman,Schohraya Spahis,Schohraya Spahis,Edgard Delvin,Emile Levy +7 more
TL;DR: Whether dietary polyphenols and micro-ecology favorably interact to promote multiple physiological functions on human organism is clearly documents.
Journal ArticleDOI
Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?
TL;DR: In this article , the authors investigated the neurotoxic effects of spike proteins in the brain and proposed a vaccine to mitigate spike protein-related detrimental effects to the brain, possibly via use of small natural molecules, especially the flavonoids luteolin and quercetin.
Journal ArticleDOI
Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview.
TL;DR: In this paper, the effects of these phytochemicals (either pure forms or polyphenolic-food) are reviewed and summarized according to affected cellular signaling pathways, and the effectiveness of the anti-aging preventive action of nutritional interventions based on diets rich in poly-phenolic food, such as the diets of the Blue zones, are discussed.
References
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Journal ArticleDOI
The ageing cortical synapse: hallmarks and implications for cognitive decline
John H. Morrison,Mark G. Baxter +1 more
TL;DR: Studies that have shed light on the cellular and synaptic changes observed in these brain structures during ageing that can be directly related to cognitive decline in young and aged animals are reviewed.
Journal ArticleDOI
Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid.
Yusuf Yilmaz,Romeo T. Toledo +1 more
TL;DR: The results indicated that dimeric, trimeric, oligomersic, oligomeric, or polymeric procyanidins account for most of the superior antioxidant capacity of grape seeds.
Journal ArticleDOI
Ageing and Parkinson's disease: why is advancing age the biggest risk factor?
TL;DR: In this article, the authors focus on the neuronal population associated with the motor symptoms of Parkinson's disease, the dopaminergic neurons of the substantia nigra, and try to understand how ageing puts these neurons at risk to the extent that a slight change in protein metabolism or mitochondrial function can push the cells over the edge leading to catastrophic cell death.
Journal ArticleDOI
An industrial approach in the search of natural antioxidants from vegetable and fruit wastes
Wieland Peschel,Ferran Sánchez-Rabaneda,Wilfried Diekmann,Andreas Plescher,Irene Gartzía,Diego Jiménez,Rosa M. Lamuela-Raventós,Susana Buxaderas,Carles Codina +8 more
TL;DR: In this article, eleven fruit and vegetable byproducts and two minor crops were screened for industrial polyphenol exploitation potential by determination of their extraction yield, total phenolic content (TPC, Folin-Ciocalteu), and antioxidant activity (NTZ/hypoxanthine superoxide assay, ferric thiocyanate method).
Journal ArticleDOI
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
Valérie Vingtdeux,Luca Giliberto,Haitian Zhao,Pallavi Chandakkar,Qingli Wu,James E. Simon,Elsa M. Janle,Jessica Lobo,Mario G. Ferruzzi,Peter Davies,Peter Davies,Philippe Marambaud,Philippe Marambaud +12 more
TL;DR: It is shown that AMPK signaling controls Aβ metabolism and mediates the anti-amyloidogenic effect of resveratrol in non-neuronal and neuronal cells, including in mouse primary neurons, and that resver atrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease.