Book ChapterDOI
Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline During Normal and Pathological Brain Aging.
S. Asha Devi,Anudita Chamoli +1 more
TLDR
A combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.Abstract:
Research in animals and humans has indicated that polyphenols can delay the age-related decline in learning, memory and neurodegenerative diseases. Among the polyphenols, berry phenolics have extensive beneficial effects because of their antioxidant and anti-inflammatory properties. Long-term consumption of grapes results in accumulation of polyphenols in the brain, which modulates cell-signalling pathways and neutralises the redox imbalance in the aging brain. Here we review the in vivo and in vitro evidence for considering grape-derived polyphenolics, the flavonoids- catechins, epicatechin, anthocyanidin, and quercetin, and non-flavonoids-gallic acid and resveratrol, as effective dietary sources to facilitate cognition in adults and lessen the decline in the old and pathogenic states, Alzheimer's and Parkinson's disease. Furthermore, a combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.read more
Citations
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SIRT1 in Neurodevelopment and Brain Senescence
TL;DR: Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals.
Journal ArticleDOI
Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue.
TL;DR: In this article, a phytosomal formulation (in olive pomace oil) of the natural flavonoid luteolin was used to mitigate brain fog in patients undergoing or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS).
Journal ArticleDOI
Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders?
Mireille Koudoufio,Yves Desjardins,Francis Feldman,Francis Feldman,Schohraya Spahis,Schohraya Spahis,Edgard Delvin,Emile Levy +7 more
TL;DR: Whether dietary polyphenols and micro-ecology favorably interact to promote multiple physiological functions on human organism is clearly documents.
Journal ArticleDOI
Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?
TL;DR: In this article , the authors investigated the neurotoxic effects of spike proteins in the brain and proposed a vaccine to mitigate spike protein-related detrimental effects to the brain, possibly via use of small natural molecules, especially the flavonoids luteolin and quercetin.
Journal ArticleDOI
Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview.
TL;DR: In this paper, the effects of these phytochemicals (either pure forms or polyphenolic-food) are reviewed and summarized according to affected cellular signaling pathways, and the effectiveness of the anti-aging preventive action of nutritional interventions based on diets rich in poly-phenolic food, such as the diets of the Blue zones, are discussed.
References
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Journal ArticleDOI
The beneficial effects of berries on cognition, motor behaviour and neuronal function in ageing.
Barbara Shukitt-Hale,Donna F. Bielinski,Francis C. Lau,Lauren M. Willis,Amanda N. Carey,James A. Joseph +5 more
TL;DR: Results showed that rats consuming the berry diets exhibited enhanced motor performance and improved cognition, specifically working memory, and the rats supplemented with BB and SB diets showed increased hippocampal neurogenesis and expression of insulin-like growth factor 1, although the improvements in working memory performance could not solely be explained by these increases.
Journal ArticleDOI
Effect of Gallic Acid on Dementia Type of Alzheimer Disease in Rats: Electrophysiological and Histological Studies.
Somayeh Hajipour,Alireza Sarkaki,Yaghoob Farbood,Akram Eidi,Pejman Mortazavi,Zohreh Valizadeh +5 more
TL;DR: Findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Aβ but with no effect on healthy rats.
Journal ArticleDOI
Grape Skin and Seed Proanthocyanidins from Monastrell × Syrah Grapes
TL;DR: The overall objective of this study is to develop new varieties that are well-adapted to the authors' agro-ecological conditions, as Monastrell is, and with a proanthocyanidin profile that will result in high-quality wines.
Journal ArticleDOI
Favorable Effects of Tea on Reducing the Cognitive Deficits and Brain Morphological Changes in Senescence-Accelerated Mice
TL;DR: Oolong and green teas could reduce the deteriorations of cognitive ability, brain degenerative changes and aging process in SAMP8, probably through the potent antioxidative activity of the tea.
Journal ArticleDOI
Resveratrol alleviates motor and cognitive deficits and neuropathology in the A53T α-synuclein mouse model of Parkinson's disease.
TL;DR: Evidence that RV treatment alleviated motor and cognitive deficits in the A53T α-synuclein mouse model of PD in a dose-dependent manner and the beneficial effects of RV against PD resulted from inhibiting α- Synuclein aggregation and cytotoxicity, lowering the levels of total α- synuclein and oligomers, reducing neuroinflammation and oxidative stress.