Book ChapterDOI
Polyphenols as an Effective Therapeutic Intervention Against Cognitive Decline During Normal and Pathological Brain Aging.
S. Asha Devi,Anudita Chamoli +1 more
TLDR
A combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.Abstract:
Research in animals and humans has indicated that polyphenols can delay the age-related decline in learning, memory and neurodegenerative diseases. Among the polyphenols, berry phenolics have extensive beneficial effects because of their antioxidant and anti-inflammatory properties. Long-term consumption of grapes results in accumulation of polyphenols in the brain, which modulates cell-signalling pathways and neutralises the redox imbalance in the aging brain. Here we review the in vivo and in vitro evidence for considering grape-derived polyphenolics, the flavonoids- catechins, epicatechin, anthocyanidin, and quercetin, and non-flavonoids-gallic acid and resveratrol, as effective dietary sources to facilitate cognition in adults and lessen the decline in the old and pathogenic states, Alzheimer's and Parkinson's disease. Furthermore, a combined intervention of polyphenols along with regular physical exercise provides cognitive benefits for the aging brain and holds promising venues for preclinical and clinical studies in formulating neuro-nutraceuticals as functional foods for a healthy brain.read more
Citations
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SIRT1 in Neurodevelopment and Brain Senescence
TL;DR: Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals.
Journal ArticleDOI
Long-COVID syndrome-associated brain fog and chemofog: Luteolin to the rescue.
TL;DR: In this article, a phytosomal formulation (in olive pomace oil) of the natural flavonoid luteolin was used to mitigate brain fog in patients undergoing or following chemotherapy for cancer (chemofog or chemobrain), as well in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) or mast cell activation syndrome (MCAS).
Journal ArticleDOI
Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their Metabolites the Key to Understand Protective Effects against Metabolic Disorders?
Mireille Koudoufio,Yves Desjardins,Francis Feldman,Francis Feldman,Schohraya Spahis,Schohraya Spahis,Edgard Delvin,Emile Levy +7 more
TL;DR: Whether dietary polyphenols and micro-ecology favorably interact to promote multiple physiological functions on human organism is clearly documents.
Journal ArticleDOI
Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?
TL;DR: In this article , the authors investigated the neurotoxic effects of spike proteins in the brain and proposed a vaccine to mitigate spike protein-related detrimental effects to the brain, possibly via use of small natural molecules, especially the flavonoids luteolin and quercetin.
Journal ArticleDOI
Impact of Polyphenolic-Food on Longevity: An Elixir of Life. An Overview.
TL;DR: In this paper, the effects of these phytochemicals (either pure forms or polyphenolic-food) are reviewed and summarized according to affected cellular signaling pathways, and the effectiveness of the anti-aging preventive action of nutritional interventions based on diets rich in poly-phenolic food, such as the diets of the Blue zones, are discussed.
References
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Journal ArticleDOI
Dietary intakes of berries and flavonoids in relation to cognitive decline.
TL;DR: This work prospectively evaluated whether greater long‐term intakes of berries and flavonoids are associated with slower rates of cognitive decline in older women.
Journal ArticleDOI
Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
Henriette van Praag,Melanie J. Lucero,Gene W. Yeo,Kimberly Stecker,Neema Heivand,Chunmei Zhao,Ed Yip,Mia Afanador,Hagen Schroeter,John Hammerstone,Fred H. Gage +10 more
TL;DR: Data show that ingestion of a single flavanol improves spatial memory retention in adult mammals, and is associated with increased angiogenesis and neuronal spine density, but not newborn cell survival, in the dentate gyrus of the hippocampus.
SIRT1 in Neurodevelopment and Brain Senescence
TL;DR: Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent deacylases that have traditionally been linked with calorie restriction and aging in mammals.
Journal ArticleDOI
Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity.
Magdalini A. Papandreou,Andriana Dimakopoulou,Zacharoula I. Linardaki,Paul Cordopatis,Dorothy Klimis-Zacas,Marigoula Margarity,Fotini N. Lamari +6 more
TL;DR: The significant cognitive enhancement observed in adult mice after short-term i.p. supplementation with the blueberry extract concentrated in polyphenols, is closely related to higher brain antioxidant properties and inhibition of AChE activity.
Journal ArticleDOI
Neuroprotective Effect of Natural Products Against Alzheimer’s Disease
Musthafa Mohamed Essa,Reshmi K. Vijayan,Gloria Castellano-Gonzalez,M. A. Memon,Nady Braidy,Gilles J. Guillemin,Gilles J. Guillemin +6 more
TL;DR: The neuroprotective effects of various naturally occurring compounds in AD is evaluating in this review.