Journal ArticleDOI
Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets
TLDR
LncRNAs are emerging as convenient and minimally invasive diagnostic/prognostic markers, and also as therapeutic target for the selective killing of cancer cells in patients.Abstract:
Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non-coding RNAs (lncRNAs) in cancer patients continues to increase. LncRNAs have shown potential as a biomarker in the diagnosis and prognosis of bladder cancer, prostate cancer, gastric cancer, pancreatic cancer, breast cancer and many other cancer types. Some lncRNAs have also been used as adjunct to improve the specificity and sensitivity of existing biomarkers. The molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE and quantitative real-time PCR have been used for examining the lncRNAs' potential. Some lncRNAs such as PCA3 is now routinely used in the clinic for the diagnosis of prostate cancer. Single nucleotide polymorphisms (SNPs) in lncRNAs can also be used as a predictor of cancer risk. Although ongoing studies continue to unravel the underlying mechanism, some lncRNAs have been used as therapeutic targets for the selective killing of cancer cells in patients. Thus lncRNAs are emerging as convenient and minimally invasive diagnostic/prognostic markers, and also as therapeutic target. Companies such as the Curna Inc., MiNA Therapeutics Ltd. and RaNA Therapeutics Inc. have been taking steps to develop lncRNA based strategies against cancer. In this review, we discuss the potential of lncRNAs as biomarkers and therapeutic targets in cancer patients.read more
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Transcriptome Analysis Identifies GATA3-AS1 as a Long Noncoding RNA Associated with Resistance to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients.
Laura Contreras-Espinosa,Nicolas Alcaraz,Inti A. De La Rosa-Velázquez,José Díaz-Chávez,Paula Cabrera-Galeana,Rosa Rebollar-Vega,Nancy Reynoso-Noverón,Héctor Maldonado-Martinez,Rodrigo González-Barrios,Rogelio Montiel-Manríquez,Diana Bautista-Sánchez,Clementina Castro-Hernández,Rosa María Álvarez-Gómez,Francisco Jiménez-Trejo,Miguel Tapia-Rodríguez,José A. García-Gordillo,Augusto Pérez-Rosas,Enrique Bargallo-Rocha,Cristian Arriaga-Canon,Luis A. Herrera +19 more
TL;DR: In this paper, the role of long noncoding RNAs (lncRNAs) as biomarkers in response to neoadjuvant chemotherapy has been extensively studied, and lncRNA expression was profiled using RNA sequencing in biopsies from patients who subsequently showed either response or no response to treatment.
Journal ArticleDOI
Preliminary screening and analysis of metastasis-related lncRNA and co-expressed papillary thyroid carcinoma mRNA.
Ming‑Hua Ge,Lie‑Hao Jiang,Qing‑Liang Wen,Zhuo Tan,Chao Chen,Chuan‑Ming Zheng,Xin Zhu,Jia‑Wen Chen,Zi‑Yu Zhu,Xiu‑Jun Cai +9 more
TL;DR: The results of the pathway cluster analysis identified that the differentially expressed genes were associated with tumor metastasis-associated signaling pathways, including the cholesterol metabolic signaling pathway, the sterol regulatory element-binding protein signaling pathway and the integrin signaled pathway, suggesting that lncRNA may regulate PTC metastasis through various signaling pathways.
Journal ArticleDOI
LINC02688 and PP7080 as novel biomarkers in early diagnosis of gastric cancer.
Sadegh Fattahi,Sadegh Fattahi,Novin Nikbakhsh,Hassan Taheri,Elham Ghadami,Mohammad Ranaee,Haleh Akhavan-Niaki +6 more
TL;DR: In this paper, the expression levels of two novel non-coding RNAs, long intergenic non-protein coding RNA 2688 (LINC02688) and LOC25845 (PP7080), were investigated for the first time in 47 gastric cancer patients.
Journal ArticleDOI
LncRNA ELF3-AS1 Promotes Nonsmall Cell Lung Cancer Cell Invasion and Migration by Downregulating miR-212
TL;DR: ELF3-AS1 is upregulated in NSCLC and promotes cancer cell invasion and migration by downregulating miR-212 through methylation.
Journal ArticleDOI
Overexpression of LncRNA SNHG1 Were Suitable for Oncolytic Adenoviruse H101 Therapy in Oral Squamous-Cell Carcinoma.
TL;DR: In this article, qRT-PCR assays were performed to detect SNHG1 expression in OSCC tissue and cells, and CCK8 assays and animal experiments used to examine cell proliferation.
References
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
Journal ArticleDOI
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem,Ophir Shalem,Neville E. Sanjana,Neville E. Sanjana,Ella Hartenian,Xi-Shun Shi,David A. Scott,David A. Scott,Tarjei S. Mikkelsen,Dirk Heckl,Benjamin L. Ebert,David E. Root,John G. Doench,Feng Zhang,Feng Zhang +14 more
TL;DR: This work shows that lentiviral delivery of a genome-scale CRISPR-Cas9 knockout (GeCKO) library targeting 18,080 genes with 64,751 unique guide sequences enables both negative and positive selection screening in human cells, and observes a high level of consistency between independent guide RNAs targeting the same gene and a high rate of hit confirmation.
Journal ArticleDOI
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
Lucia A. Hindorff,Praveen Sethupathy,Heather Junkins,Erin M. Ramos,Jayashri P. Mehta,Francis S. Collins,Teri A. Manolio +6 more
TL;DR: An online catalog of SNP-trait associations from published genome-wide association studies for use in investigating genomic characteristics of trait/disease-associated SNPs (TASs) is developed, well-suited to guide future investigations of the role of common variants in complex disease etiology.