Journal ArticleDOI
Potential of long non-coding RNAs in cancer patients: From biomarkers to therapeutic targets
TLDR
LncRNAs are emerging as convenient and minimally invasive diagnostic/prognostic markers, and also as therapeutic target for the selective killing of cancer cells in patients.Abstract:
Because of high specificity and easy detection in the tissues, serum, plasma, urine and saliva, interest in exploring the potential of long non-coding RNAs (lncRNAs) in cancer patients continues to increase. LncRNAs have shown potential as a biomarker in the diagnosis and prognosis of bladder cancer, prostate cancer, gastric cancer, pancreatic cancer, breast cancer and many other cancer types. Some lncRNAs have also been used as adjunct to improve the specificity and sensitivity of existing biomarkers. The molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE and quantitative real-time PCR have been used for examining the lncRNAs' potential. Some lncRNAs such as PCA3 is now routinely used in the clinic for the diagnosis of prostate cancer. Single nucleotide polymorphisms (SNPs) in lncRNAs can also be used as a predictor of cancer risk. Although ongoing studies continue to unravel the underlying mechanism, some lncRNAs have been used as therapeutic targets for the selective killing of cancer cells in patients. Thus lncRNAs are emerging as convenient and minimally invasive diagnostic/prognostic markers, and also as therapeutic target. Companies such as the Curna Inc., MiNA Therapeutics Ltd. and RaNA Therapeutics Inc. have been taking steps to develop lncRNA based strategies against cancer. In this review, we discuss the potential of lncRNAs as biomarkers and therapeutic targets in cancer patients.read more
Citations
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Journal ArticleDOI
Non-coding RNAs in cancer: platforms and strategies for investigating the genomic “dark matter”
Katia Grillone,Caterina Riillo,Francesca Scionti,Roberta Rocca,Giuseppe Tradigo,Pietro Hiram Guzzi,Stefano Alcaro,Maria Teresa Di Martino,Pierosandro Tagliaferri,Pierfrancesco Tassone +9 more
TL;DR: This review focuses on currently available platforms, computational analyses and experimental strategies to investigate ncRNAs in cancer, and highlights the differences among experimental approaches aimed to dissect miRNAs and lncRNAs, which are the most studied nc RNAs.
Journal ArticleDOI
Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers.
TL;DR: In this article, the authors discuss the recent advances in understanding of the specific regulatory mechanisms of long non-coding RNAs (lncRNAs) and provide a short but comprehensive description of the lncRNA functions in tumor development and progression.
Journal ArticleDOI
LncRNA-SNHG16 predicts poor prognosis and promotes tumor proliferation through epigenetically silencing p21 in bladder cancer.
Xianxiang Cao,Jing Xu,Dong Yue +2 more
TL;DR: The facts above pointed out that lncRNA-SNHG16 might be quite vital for the diagnosis and development of bladder cancer, and could even become an important therapeutic target for bladder cancer.
Journal ArticleDOI
Long Non-coding RNAs in Cancer: Implications for Diagnosis, Prognosis, and Therapy.
Yuchen Qian,Lei Shi,Zhong Luo +2 more
TL;DR: A compilation of recent publications, clinical trials and patents is presented, addressing the potential of lncRNAs that could be considered as biomarkers or therapeutic targets, with the hopes of providing promised implications for future cancer therapy.
Journal ArticleDOI
LncTarD: a manually-curated database of experimentally-supported functional lncRNA-target regulations in human diseases.
Hongying Zhao,Jian Shi,Yunpeng Zhang,Aimin Xie,Lei Yu,Caiyu Zhang,Junjie Lei,Haotian Xu,Zhijun Leng,Tengyue Li,Waidong Huang,Shihua Lin,Li Wang,Yun Xiao,Xia Li,Xia Li +15 more
TL;DR: LncTarD will be a useful resource platform for the further understanding of functions and molecular mechanisms of lncRNA deregulation in human disease, which will help to identify novel and sensitive biomarkers and therapeutic targets.
References
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Journal ArticleDOI
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem,Ophir Shalem,Neville E. Sanjana,Neville E. Sanjana,Ella Hartenian,Xi-Shun Shi,David A. Scott,David A. Scott,Tarjei S. Mikkelsen,Dirk Heckl,Benjamin L. Ebert,David E. Root,John G. Doench,Feng Zhang,Feng Zhang +14 more
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Journal ArticleDOI
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
Lucia A. Hindorff,Praveen Sethupathy,Heather Junkins,Erin M. Ramos,Jayashri P. Mehta,Francis S. Collins,Teri A. Manolio +6 more
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