PPARγ signaling and metabolism: the good, the bad and the future
Maryam Ahmadian,Jae Myoung Suh,Nasun Hah,Christopher Liddle,Annette R. Atkins,Michael Downes,Ronald M. Evans +6 more
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TLDR
This review highlights key advances in understanding PPARγ signaling in energy homeostasis and metabolic disease and also provides new explanations for adverse events linked to TZD-based therapy.Abstract:
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for type 2 diabetes. However, their unique benefits are shadowed by the risk for fluid retention, weight gain, bone loss and congestive heart failure. This raises the question as to whether it is possible to build a safer generation of PPARγ-specific drugs that evoke fewer side effects while preserving insulin-sensitizing potential. Recent studies that have supported the continuing physiologic and therapeutic relevance of the PPARγ pathway also provide opportunities to develop newer classes of molecules that reduce or eliminate adverse effects. This review highlights key advances in understanding PPARγ signaling in energy homeostasis and metabolic disease and also provides new explanations for adverse events linked to TZD-based therapy.read more
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Journal ArticleDOI
Lipid Links Inflammation, Immunity and Insulin Resistance to Cause Epidemic Diabetes
TL;DR: Association between lipid-induced inflammation and insulin resistance makes diabetes a critical disease.
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PPARγ-Induced Global H3K27 Acetylation Maintains Osteo/Cementogenic Abilities of Periodontal Ligament Fibroblasts.
Hang Yuan,Shigeki Suzuki,Shizu Hirata-Tsuchiya,Akiko Sato,Eiji Nemoto,Masahiro Saito,Hideki Shiba,Satoru Yamada +7 more
TL;DR: In this paper, an RNA-seq/ChIP-seq combined analysis identified four osteogenic transcripts, RunX2, SULF2, RCAN2, and RGMA, in the PPARγ-dependent active chromatin region marked by H3K27ac.
Journal ArticleDOI
Transcriptome analysis of porcine endometrium after LPS-induced inflammation: effects of the PPAR-gamma ligands in vitro†.
Karol Mierzejewski,Łukasz Paukszto,Aleksandra Kurzyńska,Zuzanna Kunicka,Jan Paweł Jastrzębski,Iwona Bogacka +5 more
TL;DR: The in vitro effect of PPARγ ligands on the transcriptome genes expression and alternative splicing in the porcine endometrium during LPS-stimulated inflammation is determined using RNA-seq technology.
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Altered Expression of Long Noncoding and Messenger RNAs in Diabetic Nephropathy following Treatment with Rosiglitazone.
Liwen Zhang,Ying Zhou,Fangfang Zhou,Xialian Yu,Jian Liu,Yunzi Liu,Yufei Zhu,Weiming Wang,Nan Chen +8 more
TL;DR: Bioinformatics analysis revealed that lncRNA-AI838599 emerged as a novel molecular mechanism for rosiglitazone treatment in DN through TNFα-NFκb pathway, which may indicate a new molecular regulatory approach for the development of DN therapeutic agents.
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Tandem Mass Tag-based quantitative proteomics analysis of metabolic associated fatty liver disease induced by high fat diet in mice.
TL;DR: The data showed that lipid metabolism-related pathways are closely associated with the development of MAFLD, and the identified hub proteins might be novel targets for treatingMAFLD.
References
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
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