PPARγ signaling and metabolism: the good, the bad and the future
Maryam Ahmadian,Jae Myoung Suh,Nasun Hah,Christopher Liddle,Annette R. Atkins,Michael Downes,Ronald M. Evans +6 more
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TLDR
This review highlights key advances in understanding PPARγ signaling in energy homeostasis and metabolic disease and also provides new explanations for adverse events linked to TZD-based therapy.Abstract:
Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral medications for type 2 diabetes. However, their unique benefits are shadowed by the risk for fluid retention, weight gain, bone loss and congestive heart failure. This raises the question as to whether it is possible to build a safer generation of PPARγ-specific drugs that evoke fewer side effects while preserving insulin-sensitizing potential. Recent studies that have supported the continuing physiologic and therapeutic relevance of the PPARγ pathway also provide opportunities to develop newer classes of molecules that reduce or eliminate adverse effects. This review highlights key advances in understanding PPARγ signaling in energy homeostasis and metabolic disease and also provides new explanations for adverse events linked to TZD-based therapy.read more
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PPARγ agonists: potential treatment for autism spectrum disorder by inhibiting the canonical WNT/β-catenin pathway
TL;DR: This review focuses on the hypothesis of an opposed interplay between PPARγ and the canonical WNT/β-catenin pathway in ASD and the potential role ofPPARγ agonists as treatment for ASD.
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High Dose of Dietary Nicotinamide Riboside Induces Glucose Intolerance and White Adipose Tissue Dysfunction in Mice Fed a Mildly Obesogenic Diet
Wenbiao Shi,Wenbiao Shi,Maria A. Hegeman,Maria A. Hegeman,Atanaska Doncheva,Melissa Bekkenkamp-Grovenstein,Vincent C. J. de Boer,Jaap Keijer +7 more
TL;DR: In conclusion, high-dose NR induces the onset of WAT dysfunction, which may in part explain the deterioration of metabolic health.
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Pathways Implicated in Tadalafil Amelioration of Duchenne Muscular Dystrophy.
Valeria De Arcangelis,Georgios Strimpakos,Francesca Gabanella,Nicoletta Corbi,Siro Luvisetto,Armando Magrelli,Annalisa Onori,Claudio Passananti,Cinzia Pisani,Sophie Rome,Cinzia Severini,Fabio Naro,Elisabetta Mattei,Maria Grazia Di Certo,Lucia Monaco +14 more
TL;DR: Results show that PDE5 inhibition can ameliorate dystrophy by acting at different levels, and tadalafil can lead to increased lipid metabolism, a switch towards slow oxidative fibers driven by the up‐regulation of PGC‐1α, and an increased protein synthesis efficiency.
Journal ArticleDOI
Cyanidin 3-O-β-glucopyranoside activates peroxisome proliferator-activated receptor-γ and alleviates cognitive impairment in the APP(swe)/PS1(ΔE9) mouse model.
TL;DR: Cy3G ameliorates amyloid β peptide-induced injury both in vitro and in vivo through the PPARγ pathway and may be used as an ideal alternative to traditional disease-modifying treatments against AD.
Journal ArticleDOI
IL-25 or IL-17E Protects against High-Fat Diet-Induced Hepatic Steatosis in Mice Dependent upon IL-13 Activation of STAT6.
An-Jiang Wang,Zhonghan Yang,Viktoriya Grinchuk,Allen Smith,Bolin Qin,Nonghua Lu,Duan Wang,Hongbing Wang,Thirumalai R. Ramalingam,Thomas A. Wynn,Joseph F. Urban,Terez Shea-Donohue,Aiping Zhao +12 more
TL;DR: It is demonstrated that dysregulated IL-25 expression contributes to lipid accumulation, whereas exogenous IL- 25 protects against hepatic steatosis through IL-13 activation of STAT6.
References
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Brown Adipose Tissue: Function and Physiological Significance
Barbara Cannon,Jan Nedergaard +1 more
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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Steven E. Nissen,Kathy Wolski +1 more
TL;DR: Patients and providers should consider the potential for serious adverse cardiovascular effects of treatment with rosiglitazone for type 2 diabetes mellitus as well as the availability of outcome data for myocardial infarction and death from cardiovascular causes.
Journal ArticleDOI
An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)
Jürgen M. Lehmann,Linda B. Moore,Tracey Smith-Oliver,William O. Wilkison,Timothy M. Willson,Steven A. Kliewer +5 more
TL;DR: It is reported that thiazolidinediones are potent and selective activators of peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily recently shown to function in adipogenesis, and raised the intriguing possibility that PPARγ is a target for the therapeutic actions of this class of compounds.
Journal ArticleDOI
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Journal ArticleDOI
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Keiji Kuba,Yumiko Imai,Shuan Rao,Hong Gao,Feng Guo,Bin Guan,Yi Huan,Peng Yang,Yanli Zhang,Wei Deng,Linlin Bao,Binlin Zhang,Guang Liu,Zhong Wang,Mark C. Chappell,Yanxin Liu,Dexian Zheng,Andreas Leibbrandt,Teiji Wada,Arthur S. Slutsky,Depei Liu,Chuan Qin,Chengyu Jiang,Josef M. Penninger +23 more
TL;DR: A molecular explanation why SARS-CoV infections cause severe and often lethal lung failure and suggest a rational therapy for SARS and possibly other respiratory disease viruses is provided.
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