Journal ArticleDOI
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more
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TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.Abstract:
Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects is not known. Methods. We conducted a randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Women planning a pregnancy (in most cases their first) were randomly assigned to receive a single tablet of a vitamin supplement (containing 12 vitamins, including 0.8 mg of folic acid; 4 minerals; and 3 trace elements) or a trace-element supplement (containing copper, manganese, zinc, and a very low dose of vitamin C) daily for at least one month before conception and until the date of the second missed menstrual period or later. Results. Pregnancy was confirmed in 4753 women. The outcome of the pregnancy (whether the fetu...read more
Citations
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The common mthfr c677t and a1298c variants are not associated with the risk of non-syndromic cleft lip/palate in northern venezuela
TL;DR: Overall, the findings fail to support a causal role of either the MTHFR C677T or A1298C variants in the pathogenesis of nsCL/P in northern Venezuela.
Journal ArticleDOI
Prevention of neural tube defects by the fortification of flour with folic acid: a population-based retrospective study in Brazil.
Leonor Maria Pacheco Santos,Roberto Carlos Reyes Lecca,Juan José Cortez-Escalante,Mauro Niskier Sanchez,Humberto Gabriel Rodrigues +4 more
TL;DR: The introduction of the mandatory fortification of flour with iron and folic acid in Brazil was followed by a significant reduction in the prevalence of neural tube defects in the study area.
Journal ArticleDOI
Analysis of the MTHFD1 promoter and risk of neural tube defects.
Nicola Carroll,Faith Pangilinan,Anne M. Molloy,James Troendle,James L. Mills,Peadar N. Kirke,Lawrence C. Brody,John M. Scott,Anne Parle-McDermott +8 more
TL;DR: It is demonstrated that a common SNP within the window of transcriptional initiation exerts a significant effect on promoter activity in vitro, providing the first insight into how MTHFD1 is regulated and further emphasise its importance during embryonic development.
Book ChapterDOI
B‐Group Vitamins Production by Probiotic Lactic Acid Bacteria
Jean Guy LeBlanc,Jonathan Emiliano Laiño,Marianela Juárez del Valle,Graciela Savoy de Giori,Fernando Sesma,María Pía Taranto +5 more
TL;DR: Film: Leblanc, Jean Guy Joseph, et al. (2015).
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Are primary care residents adequately prepared to care for women of reproductive age
TL;DR: A 1991 study of 115 internal medicine and 28 family practice residents at a large inner-city public hospital finds that both groups would perform poorly in providing preconception counseling to women of reproductive age.
References
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Journal ArticleDOI
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
TL;DR: It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Journal ArticleDOI
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
R.W. Smithells,Sheila Sheppard,C. J. Schorah,Mary J. Seller,N.C. Nevin,Rodney Harris,Andrew P. Read,D.W. Fielding +7 more
TL;DR: Women who had previously given birth to one or more infants with a neural-tube defect were recruited into a trial of periconceptional multivitamin supplementation and found no difference in the number of infants/fetuses with an NTD.
Journal ArticleDOI
Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia.
Carol Bower,Fiona J. Stanley +1 more
TL;DR: The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable.
Journal ArticleDOI
The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects
James L. Mills,George G. Rhoads,Simpson Jl,G C Cunningham,Mary Conley,Melinda R. Lassman,Walden Me,Depp Or,Howard J. Hoffman +8 more
TL;DR: It is concluded that the periconceptional use of multivitamins or folate-containing supplements by American women does not decrease the risk of having an infant with a neural-tube defect.
Journal ArticleDOI
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
TL;DR: The results suggest that folic acid supplementation might be an effective method of primary prevention of neural tube defects.