Journal ArticleDOI
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more
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TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.Abstract:
Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects is not known. Methods. We conducted a randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Women planning a pregnancy (in most cases their first) were randomly assigned to receive a single tablet of a vitamin supplement (containing 12 vitamins, including 0.8 mg of folic acid; 4 minerals; and 3 trace elements) or a trace-element supplement (containing copper, manganese, zinc, and a very low dose of vitamin C) daily for at least one month before conception and until the date of the second missed menstrual period or later. Results. Pregnancy was confirmed in 4753 women. The outcome of the pregnancy (whether the fetu...read more
Citations
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Journal ArticleDOI
Cardiovascular abnormalities in Folr1 knockout mice and folate rescue.
Huiping Zhu,Bogdan J. Wlodarczyk,Melissa L. Scott,Wei Yu,Michelle Merriweather,Janee Gelineau-van Waes,Robert J. Schwartz,Richard H. Finnell,Richard H. Finnell,Richard H. Finnell +9 more
TL;DR: The observations suggest that the beneficial effect of folic acid for congenital heart defects might be mediated via its impact on neural crest cells and by gene regulation of signaling pathways involved in the development of the pharyngeal arches and the secondary heart field.
Journal ArticleDOI
Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women
TL;DR: A once-a-week 2800’μg folic acid supplement can increase women's red blood cell folate to concentrations associated with a reduced risk of bearing a child with a neural tube defect, but is less effective than a 400 μg daily supplement.
Journal ArticleDOI
Teratologic evaluation of 178 infants born to mothers who attempted suicide by drugs during pregnancy
TL;DR: Drugs taken by women in attempting suicide do not seem to pose a risk for structural birth defects in the offspring, even though large doses of drugs were used in 27 cases between the 3rd and 8th weeks of fetal development.
Journal ArticleDOI
Healthcare databases in Europe for studying medicine use and safety during pregnancy
Rachel Charlton,Amanda J. Neville,Sue Jordan,Anna Pierini,Christine Damase-Michel,Kari Klungsøyr,Kari Klungsøyr,Anne-Marie Nybo Andersen,Anne Vinkel Hansen,Rosa Gini,Jens H. J. Bos,Aurora Puccini,Caroline Hurault-Delarue,Caroline J. Brooks,Lolkje T. W. de Jong-van den Berg,Corinne S de Vries +15 more
TL;DR: A number of electronic healthcare databases in Europe are described in terms of the population covered, the source of the data captured and the availability of data on key variables required for evaluating medicine use and medicine safety during pregnancy.
Journal ArticleDOI
Neural tube defects, vitamins and homocysteine
TL;DR: From studies with the rat embryo in vitro, it can be concluded that the de- and remethylation cycle of methionine, being folate and vitamin B12 dependent, is crucial for embryonic and fetal growth probably via generation of DNA, proteins and polyamines.
References
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Journal ArticleDOI
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
TL;DR: It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Journal ArticleDOI
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
R.W. Smithells,Sheila Sheppard,C. J. Schorah,Mary J. Seller,N.C. Nevin,Rodney Harris,Andrew P. Read,D.W. Fielding +7 more
TL;DR: Women who had previously given birth to one or more infants with a neural-tube defect were recruited into a trial of periconceptional multivitamin supplementation and found no difference in the number of infants/fetuses with an NTD.
Journal ArticleDOI
Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia.
Carol Bower,Fiona J. Stanley +1 more
TL;DR: The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable.
Journal ArticleDOI
The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects
James L. Mills,George G. Rhoads,Simpson Jl,G C Cunningham,Mary Conley,Melinda R. Lassman,Walden Me,Depp Or,Howard J. Hoffman +8 more
TL;DR: It is concluded that the periconceptional use of multivitamins or folate-containing supplements by American women does not decrease the risk of having an infant with a neural-tube defect.
Journal ArticleDOI
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
TL;DR: The results suggest that folic acid supplementation might be an effective method of primary prevention of neural tube defects.