Journal ArticleDOI
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more
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TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.Abstract:
Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects is not known. Methods. We conducted a randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Women planning a pregnancy (in most cases their first) were randomly assigned to receive a single tablet of a vitamin supplement (containing 12 vitamins, including 0.8 mg of folic acid; 4 minerals; and 3 trace elements) or a trace-element supplement (containing copper, manganese, zinc, and a very low dose of vitamin C) daily for at least one month before conception and until the date of the second missed menstrual period or later. Results. Pregnancy was confirmed in 4753 women. The outcome of the pregnancy (whether the fetu...read more
Citations
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Journal ArticleDOI
Global Strategies to Reduce the Health Care Burden of Craniofacial Anomalies: Report of WHO Meetings on International Collaborative Research on Craniofacial Anomalies
TL;DR: This report will serve as a road map for making collaboration the rule and not the exception and hopefully be a stimulus for the creation of partnerships between international research teams and funding agencies.
Journal ArticleDOI
Congenital heart defects and maternal derangement of homocysteine metabolism.
Livia Kapusta,Michèle L.M. Haagmans,Eric A.P. Steegers,Marinus H.M. Cuypers,Henk J. Blom,Tom K.A.B. Eskes +5 more
TL;DR: Maternal hyperhomocysteine concentrations were significantly higher in the study group as compared with 56 control subjects, suggesting that mother-child friendship may be a risk factor for congenital heart defects.
Journal ArticleDOI
Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida
TL;DR: This study did not find an increased spina bifida risk for infants who were heterozygous or homozygous for RFC1 A80G, but it did reveal modest evidence for a gene-nutrient interaction between infant homozygosity for the RFC1 G80/G80 genotype and maternal periconceptional intake of vitamins containing folic acid.
Journal ArticleDOI
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia.
Wai Yee Wong,Tom K.A.B. Eskes,Anne‐Marie Kuijpers‐Jagtman,Paul H.M. Spauwen,Eric A.P. Steegers,Chris M.G. Thomas,Ben C.J. Hamel,Henk J. Blom,Régine P.M. Steegers-Theunissen +8 more
TL;DR: Evidence is offered that maternal hyperhomocysteinemia may be a risk factor for having nonsyndromic orofacial cleft offspring and vitamin B6 concentrations appeared to be significantly lower in cases compared with controls.
Journal ArticleDOI
Do multivitamin or folic acid supplements reduce the risk for congenital heart defects? Evidence and gaps.
TL;DR: The evidence is reviewed and the evidence suggested is a framework for further investigation in this area, and the use of multivitamin supplements around the time of conception and during early pregnancy with a reduced risk for heart defects in the offspring is suggested.
References
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Journal ArticleDOI
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
TL;DR: It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Journal ArticleDOI
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
R.W. Smithells,Sheila Sheppard,C. J. Schorah,Mary J. Seller,N.C. Nevin,Rodney Harris,Andrew P. Read,D.W. Fielding +7 more
TL;DR: Women who had previously given birth to one or more infants with a neural-tube defect were recruited into a trial of periconceptional multivitamin supplementation and found no difference in the number of infants/fetuses with an NTD.
Journal ArticleDOI
Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia.
Carol Bower,Fiona J. Stanley +1 more
TL;DR: The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable.
Journal ArticleDOI
The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects
James L. Mills,George G. Rhoads,Simpson Jl,G C Cunningham,Mary Conley,Melinda R. Lassman,Walden Me,Depp Or,Howard J. Hoffman +8 more
TL;DR: It is concluded that the periconceptional use of multivitamins or folate-containing supplements by American women does not decrease the risk of having an infant with a neural-tube defect.
Journal ArticleDOI
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
TL;DR: The results suggest that folic acid supplementation might be an effective method of primary prevention of neural tube defects.