Journal ArticleDOI
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more
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TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.Abstract:
Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects is not known. Methods. We conducted a randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Women planning a pregnancy (in most cases their first) were randomly assigned to receive a single tablet of a vitamin supplement (containing 12 vitamins, including 0.8 mg of folic acid; 4 minerals; and 3 trace elements) or a trace-element supplement (containing copper, manganese, zinc, and a very low dose of vitamin C) daily for at least one month before conception and until the date of the second missed menstrual period or later. Results. Pregnancy was confirmed in 4753 women. The outcome of the pregnancy (whether the fetu...read more
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Journal ArticleDOI
Folic acid sensitive birth defects in association with intrauterine exposure to folic acid antagonists.
Willemijn M. Meijer,Hermien E. K. de Walle,Wilhelmina S. Kerstjens-Frederikse,Lolkje T. W. de Jong-van den Berg +3 more
TL;DR: This study supports the findings of various other studies on the teratogenicity of antiepileptics and finds no effect after exposure to a dihydrofolate reductase inhibitor and an association between DHFRIs and FA sensitive defects was not found.
Journal Article
Identifying women who might benefit from higher doses of folic acid in pregnancy
Deborah Kennedy,Gideon Koren +1 more
TL;DR: Women who are at high risk of having babies with neural tube defects and who would benefit from higher doses of folic acid include those with certain folate-enzyme genotypes, previous pregnancies with neuralTube defects, diabetes, malabsorption disorders, or obesity, or those who take antifolate medications or smoke.
Journal ArticleDOI
Effect of folic acid intervention on the change of serum folate level in hypertensive Chinese adults: Do methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms affect therapeutic responses?
Xianhui Qin,Jianping Li,Yimin Cui,Zeyuan Liu,Zhigang Zhao,Junbo Ge,Deming Guan,Jian Hu,Yanni Wang,Fumin Zhang,Xin Xu,Xiaobin Wang,Xiping Xu,Yong Huo +13 more
TL;DR: It is demonstrated that MTHFR C677T polymorphisms can not only affect serum folate levels at the baseline and post-FA treatment, but also therapeutic responses to various dosages and durations of FA supplementation.
Journal ArticleDOI
Application of stable isotope dilution assays based on liquid chromatography-tandem mass spectrometry for the assessment of folate bioavailability
TL;DR: The relative bioavailability of folate following meal A exceeded significantly the suggested value of 50% for food folates by taking the dose-normalized area under the curve (AUC) following ingestion of meal B as reference.
Journal ArticleDOI
NTP-CERHR expert panel report on the reproductive and developmental toxicity of methanol.
M.D. Shelby,Christopher J. Portier,Lynn R. Goldman,John A. Moore,Annette R. Iannucci,Gloria D. Jahnke,Steve Donkin,Ntp-Cerhr Expert Panel +7 more
TL;DR: This report is a product of the Expert Panel and is intended to interpret the strength of scientific evidence that a given exposure or exposure circumstance may pose a hazard to reproduction and the health and welfare of children.
References
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Journal ArticleDOI
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
TL;DR: It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Journal ArticleDOI
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
R.W. Smithells,Sheila Sheppard,C. J. Schorah,Mary J. Seller,N.C. Nevin,Rodney Harris,Andrew P. Read,D.W. Fielding +7 more
TL;DR: Women who had previously given birth to one or more infants with a neural-tube defect were recruited into a trial of periconceptional multivitamin supplementation and found no difference in the number of infants/fetuses with an NTD.
Journal ArticleDOI
Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia.
Carol Bower,Fiona J. Stanley +1 more
TL;DR: The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable.
Journal ArticleDOI
The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects
James L. Mills,George G. Rhoads,Simpson Jl,G C Cunningham,Mary Conley,Melinda R. Lassman,Walden Me,Depp Or,Howard J. Hoffman +8 more
TL;DR: It is concluded that the periconceptional use of multivitamins or folate-containing supplements by American women does not decrease the risk of having an infant with a neural-tube defect.
Journal ArticleDOI
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
TL;DR: The results suggest that folic acid supplementation might be an effective method of primary prevention of neural tube defects.