Journal ArticleDOI
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more
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TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.Abstract:
Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects is not known. Methods. We conducted a randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Women planning a pregnancy (in most cases their first) were randomly assigned to receive a single tablet of a vitamin supplement (containing 12 vitamins, including 0.8 mg of folic acid; 4 minerals; and 3 trace elements) or a trace-element supplement (containing copper, manganese, zinc, and a very low dose of vitamin C) daily for at least one month before conception and until the date of the second missed menstrual period or later. Results. Pregnancy was confirmed in 4753 women. The outcome of the pregnancy (whether the fetu...read more
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Journal ArticleDOI
Neural Tube Defects among Mexican Americans Living on the US-Mexico Border: Effects of Folic Acid and Dietary Folate
Lucina Suarez,Katherine A. Hendricks,Sharon P. Cooper,Anne M. Sweeney,Robert J. Hardy,Russell Larsen +5 more
TL;DR: Combined folic acid intake from diet and supplements showed only a modest risk reduction for intakes of > or = 1.0 mg per day, suggesting an apparent decreased effect in this population of Mexican Americans.
Journal ArticleDOI
Folic acid supplements during early pregnancy and likelihood of multiple births: a population-based cohort study.
Zhu Li,Jacqueline Gindler,Hong Wang,Robert J. Berry,Song Li,Adolfo Correa,Jun-chi Zheng,J. David Erickson,Yu Wang +8 more
TL;DR: The findings suggest that consumption of folic acid supplements during pregnancy is not associated with an increased occurrence of multiple births.
Journal ArticleDOI
Noninvasive and Minimally-Invasive Optical Monitoring Technologies
TL;DR: There is a critical need for the development of less invasive portable technologies to assess micronutrient status, environmental hazards, and for other disease-related substances, such as billirubin for infant jaundice.
Journal ArticleDOI
Effect of maternal methionine supplementation on the transcriptome of bovine preimplantation embryos.
Francisco Peñagaricano,A.H. Souza,P.D. Carvalho,Ashley M. Driver,Rocio Gambra,Jenna Kropp,Katherine S. Hackbart,Daniel Luchini,Randy D. Shaver,Milo C. Wiltbank,Hasan Khatib +10 more
TL;DR: Evidence is provided that supplementing methionine to dams prior to conception and during the preimplantation period can modulate gene expression in bovine blastocysts.
Journal ArticleDOI
Folate bioavailability: implications for establishing dietary recommendations and optimizing status.
TL;DR: The summarizes and integrates bioavailability estimates derived from studies that use whole-diet approaches and highlights the influences of genetics, ethnicity-race, and sex as postabsorptive bioavailability modifiers and discusses the adequacy of the US folate Recommended Dietary Allowance in achieving folate sufficiency in select subpopulations.
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Journal ArticleDOI
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
TL;DR: It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Journal ArticleDOI
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
R.W. Smithells,Sheila Sheppard,C. J. Schorah,Mary J. Seller,N.C. Nevin,Rodney Harris,Andrew P. Read,D.W. Fielding +7 more
TL;DR: Women who had previously given birth to one or more infants with a neural-tube defect were recruited into a trial of periconceptional multivitamin supplementation and found no difference in the number of infants/fetuses with an NTD.
Journal ArticleDOI
Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia.
Carol Bower,Fiona J. Stanley +1 more
TL;DR: The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable.
Journal ArticleDOI
The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects
James L. Mills,George G. Rhoads,Simpson Jl,G C Cunningham,Mary Conley,Melinda R. Lassman,Walden Me,Depp Or,Howard J. Hoffman +8 more
TL;DR: It is concluded that the periconceptional use of multivitamins or folate-containing supplements by American women does not decrease the risk of having an infant with a neural-tube defect.
Journal ArticleDOI
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
TL;DR: The results suggest that folic acid supplementation might be an effective method of primary prevention of neural tube defects.