Journal ArticleDOI
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more
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TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.Abstract:
Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects is not known. Methods. We conducted a randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Women planning a pregnancy (in most cases their first) were randomly assigned to receive a single tablet of a vitamin supplement (containing 12 vitamins, including 0.8 mg of folic acid; 4 minerals; and 3 trace elements) or a trace-element supplement (containing copper, manganese, zinc, and a very low dose of vitamin C) daily for at least one month before conception and until the date of the second missed menstrual period or later. Results. Pregnancy was confirmed in 4753 women. The outcome of the pregnancy (whether the fetu...read more
Citations
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Journal ArticleDOI
Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial
Renate M. Winkels,Ingeborg A. Brouwer,Ingeborg A. Brouwer,Robert Clarke,Martijn B. Katan,Petra Verhoef +5 more
TL;DR: In this paper, the effect of consumption of bread fortified with modest amounts of folic acid and vitamin B-12 on folate and vitamin b-12 status in healthy older persons living in the Netherlands was investigated.
Book ChapterDOI
Meningomyelocele: management in utero and post natum
TL;DR: The number of new cases of meningomyelocele presenting to the authors' clinic has decreased from an average of 30 per year between 1970 and 1987 to 14 between 1988 and 1992.
Journal ArticleDOI
Periconceptional use of folic acid supplements in Oslo
TL;DR: Evaluated the use of folic acid supplements among pregnant women in Oslo and explored demographic factors that were associated with periconceptional intake to decrease the occurrence of neural tube defects.
Journal ArticleDOI
Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries.
Megan W. Bourassa,Saskia J. M. Osendarp,Seth Adu-Afarwuah,Saima Ahmed,Clayton Ajello,Gilles Bergeron,Robert E. Black,Parul Christian,Parul Christian,Simon Cousens,Saskia de Pee,Saskia de Pee,Saskia de Pee,Kathryn G. Dewey,Shams El Arifeen,Reina Engle-Stone,Alison Fleet,Alison D. Gernand,John Hoddinott,Rolf Klemm,Klaus Kraemer,Roland Kupka,Erin McLean,Sophie E. Moore,Lynnette M. Neufeld,Lars Åke Persson,Kathleen M. Rasmussen,Anuraj H. Shankar,Emily R. Smith,Emily R. Smith,Christopher R. Sudfeld,Emorn Udomkesmalee,Stephen A. Vosti +32 more
TL;DR: The data suggest that countries with inadequate micronutrient intakes should consider supplementing pregnant women with MMS as a cost‐effective method to reduce the risk of adverse birth outcomes.
Journal ArticleDOI
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population
TL;DR: Novel associations are identified between SNPs in CD320 and DNMT2 and SHMT1, which had been previously associated with colorectal cancer and cardiovascular disease risk, and RBC folate status, which provide a plausible metabolic rationale for the association of these SNPs with B vitamin-related diseases.
References
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Journal ArticleDOI
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
TL;DR: It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Journal ArticleDOI
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
R.W. Smithells,Sheila Sheppard,C. J. Schorah,Mary J. Seller,N.C. Nevin,Rodney Harris,Andrew P. Read,D.W. Fielding +7 more
TL;DR: Women who had previously given birth to one or more infants with a neural-tube defect were recruited into a trial of periconceptional multivitamin supplementation and found no difference in the number of infants/fetuses with an NTD.
Journal ArticleDOI
Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia.
Carol Bower,Fiona J. Stanley +1 more
TL;DR: The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable.
Journal ArticleDOI
The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects
James L. Mills,George G. Rhoads,Simpson Jl,G C Cunningham,Mary Conley,Melinda R. Lassman,Walden Me,Depp Or,Howard J. Hoffman +8 more
TL;DR: It is concluded that the periconceptional use of multivitamins or folate-containing supplements by American women does not decrease the risk of having an infant with a neural-tube defect.
Journal ArticleDOI
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
TL;DR: The results suggest that folic acid supplementation might be an effective method of primary prevention of neural tube defects.