Journal ArticleDOI
Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation
Andrew E. Czeizel,István Dudás +1 more
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TLDR
A randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects.Abstract:
Background. The risk of recurrent neural-tube defects is decreased in women who take folic acid or multivitamins containing folic acid during the periconceptional period. The extent to which such supplementation can reduce the first occurrence of defects is not known. Methods. We conducted a randomized, controlled trial of periconceptional multivitamin supplementation to test the efficacy of this treatment in reducing the incidence of a first occurrence of neural-tube defects. Women planning a pregnancy (in most cases their first) were randomly assigned to receive a single tablet of a vitamin supplement (containing 12 vitamins, including 0.8 mg of folic acid; 4 minerals; and 3 trace elements) or a trace-element supplement (containing copper, manganese, zinc, and a very low dose of vitamin C) daily for at least one month before conception and until the date of the second missed menstrual period or later. Results. Pregnancy was confirmed in 4753 women. The outcome of the pregnancy (whether the fetu...read more
Citations
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Journal ArticleDOI
Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice
Bogdan J. Wlodarczyk,Ofer Spiegelstein,Janee Gelineau-van Waes,Roseann L. Vorce,Xiufen Lu,Christopher Le,Richard H. Finnell,Richard H. Finnell +7 more
TL;DR: It is suggested that impaired folate transport in the developing mouse embryo increases the risk for developmental defects following in utero exposure to sodium arsenate and that these differences are not due to differences in metabolism of arsenic.
Journal ArticleDOI
Folic acid and primary prevention of neural tube defects: A review.
TL;DR: With 4 mg folic acid daily, it may take 20 weeks to reach red-blood-cell folate levels between 1050 and 1340 nmol/L, optimal for reduction of the neural tube defect risk, therefore, folic Acid supplementation should be started 5-6 months before conception.
Journal ArticleDOI
Influence of processing on total, monoglutamate and polyglutamate folate contents of leeks, cauliflower, and green beans.
Alida Melse-Boonstra,Petra Verhoef,Erik J M Konings,Marijke Van Dusseldorp,A.M. Matser,Peter C. H. Hollman,Saskia Meyboom,Frans J. Kok,Clive E. West +8 more
TL;DR: In this paper, the authors showed that conversion of folate polyglutamate to the monoglutamate form in vegetables is possible by certain processing treatments, which could lead to vegetables with higher folate bioavailability.
Journal ArticleDOI
Children with spina bifida: key clinical issues.
TL;DR: The sensory and motor impairments, neurologic disorders, orthopedic and cognitive impairment, and skin and other problems associated with spina bifida are discussed.
Journal ArticleDOI
Factors influencing the risk of abnormal pregnancy outcome in epileptic women: A multi-centre prospective study
Régine P.M. Steegers-Theunissen,Willy O. Renier,George F. Borm,Chris M.G. Thomas,Hans M.W.M. Merkus,Dolf A.W.Op de Coul,Pieter A. De Jong,Herman P. van Geijn,Maurice Wouters,Tom K.A.B. Eskes +9 more
TL;DR: There was a significant correlation between the prevalence of abnormal pregnancy outcome and duration of epilepsy and AED treatment and no significant effect in terms of the type, the number or the serum level of the AEDs could be established.
References
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Journal ArticleDOI
Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects.
TL;DR: It is concluded that folic acid supplementation might be a cheap, safe, and effective method of primary prevention of neural-tube defects but that this must be confirmed in a large, multicentre trial.
Journal ArticleDOI
Possible prevention of neural-tube defects by periconceptional vitamin supplementation.
R.W. Smithells,Sheila Sheppard,C. J. Schorah,Mary J. Seller,N.C. Nevin,Rodney Harris,Andrew P. Read,D.W. Fielding +7 more
TL;DR: Women who had previously given birth to one or more infants with a neural-tube defect were recruited into a trial of periconceptional multivitamin supplementation and found no difference in the number of infants/fetuses with an NTD.
Journal ArticleDOI
Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia.
Carol Bower,Fiona J. Stanley +1 more
TL;DR: The hypothesis that the dietary intake of folate in early pregnancy protects against the occurrence of isolated neural‐tube defects in infants is supported, and trends were seen when total folate intake was the exposure variable.
Journal ArticleDOI
The Absence of a Relation between the Periconceptional Use of Vitamins and Neural-Tube Defects
James L. Mills,George G. Rhoads,Simpson Jl,G C Cunningham,Mary Conley,Melinda R. Lassman,Walden Me,Depp Or,Howard J. Hoffman +8 more
TL;DR: It is concluded that the periconceptional use of multivitamins or folate-containing supplements by American women does not decrease the risk of having an infant with a neural-tube defect.
Journal ArticleDOI
Primary prevention of neural tube defects with folic acid supplementation: Cuban experience.
TL;DR: The results suggest that folic acid supplementation might be an effective method of primary prevention of neural tube defects.