Primary ammonium/tertiary amine-mediated controlled ring opening polymerisation of amino acid N-carboxyanhydrides.
TLDR
Stable commercial primary ammonium chlorides were combined with tertiary amines to initiate the controlled ring opening polymerisation of amino acid N-carboxyanhydrides to yield polypeptides with defined end group structure, predetermined molar mass and narrow molarmass distribution.About:
This article is published in Chemical Communications.The article was published on 2015-10-15 and is currently open access. It has received 43 citations till now. The article focuses on the topics: Tertiary amine & Molar mass distribution.read more
Citations
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High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis
Rebecca L. Greenaway,Valentina Santolini,Michael J. Bennison,Ben M. Alston,Chloe J. Pugh,Marc A. Little,Marcin Miklitz,E. G. B. Eden-Rump,Rob Clowes,A. Shakil,H. J. Cuthbertson,H. Armstrong,Michael E. Briggs,Kim E. Jelfs,Andrew I. Cooper +14 more
TL;DR: Computational screening with high-throughput robotic synthesis is combined to create a hybrid discovery workflow for discovering new organic cage molecules, and by extension, other supramolecular systems that form cleanly in one-pot syntheses.
Journal ArticleDOI
Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids.
Alicia Rasines Mazo,Stephanie Allison-Logan,Fatemeh Karimi,Fatemeh Karimi,Nicholas Jun-An Chan,Wenlian Qiu,Wei Duan,Neil M O'Brien-Simpson,Greg G. Qiao +8 more
TL;DR: Key architectures obtained through NCA ROP or in combination with other polymerization methods are reviewed, as these play an important role in the wide range of applications towards which polypeptides have been applied.
Journal ArticleDOI
Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N -carboxyanhydrides
TL;DR: Lithium hexamethyldisilazide is used to initiate α-amino acid N-carboxyanhydride polymerizations that is very fast and can be conducted in an open vessel, and rapid synthesis of polypeptide libraries for high-throughput functional screening.
Journal ArticleDOI
Methacrylate-ended polypeptides and polypeptoids for antimicrobial and antifouling coatings
TL;DR: This dual-functional polymer brush coating can be immobilized on the surface of multiple categories of materials through the mussel-inspired pDA coating, and thus should be widely applicable for combating infection in many classes of bio-medical materials.
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Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives.
Maochao Zheng,Miao Pan,Wancong Zhang,Huanchang Lin,Shenlang Wu,Chao Lu,Shijie Tang,Daojun Liu,Jianfeng Cai +8 more
TL;DR: This review aims to summarize the recent advances in PLL-based nanomaterials in these biomedical fields over the last decade by describing the synthesis of PLL and its derivatives and the main text of their recent biomedical applications and translational studies.
References
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Journal ArticleDOI
Living Polymerization of α‐Amino Acid N‐Carboxyanhydrides (NCA) upon Decreasing the Reaction Temperature
TL;DR: In this paper, the n-hexylamine-initiated polymerization of Ne-trifluoroacetyl-L-lysine N-carboxyanhydride in N,N-dimethyformamide was studied by nonaqueous capillary electrophoresis.
Journal ArticleDOI
Polypeptide and Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization
TL;DR: This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers and issues relating to obtaining these highly functional copolymer in pure form are detailed.
Journal ArticleDOI
Nucleophilic Reactivities of Primary and Secondary Amines in Acetonitrile
TL;DR: In this article, the second-order rate constants k2 for the attack on the electrophiles by the amines were determined from the linear free energy relationship log(k2 (20 °C) = s(N + E).
Journal ArticleDOI
Using controlled radical polymerisation techniques for the synthesis of functional polymers containing amino acid moieties
TL;DR: There is great current interest in bridging the gap between robust synthetic polymers and complex biological polymers to allow for the preparation of novel functional, well-defined, biocompatible and tailorable materials as discussed by the authors.
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