Primary head and neck tumour-derived fibroblasts promote lymphangiogenesis in a lymphatic organotypic co-culture model.
Karina M. Lugo-Cintrón,Jose M. Ayuso,Jose M. Ayuso,Mouhita Humayun,Max M. Gong,Max M. Gong,Sheena C. Kerr,Suzanne M. Ponik,Paul M. Harari,María Virumbrales-Muñoz,David J. Beebe +10 more
TLDR
In this article, a microfluidic in vitro model of a tubular lymphatic vessel was co-cultured with primary TDF from head and neck cancer patients to evaluate the effect of TDF on lymphangiogenesis.About:
This article is published in EBioMedicine.The article was published on 2021-11-01 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Lymphangiogenesis & Lymphatic vessel.read more
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A role for microfluidic systems in precision medicine
TL;DR: In this article , the authors review past applications of microfluidic systems for precision medicine and discuss the present and potential future role of functional microfluideic assays as treatment predictors.
Journal ArticleDOI
From microfluidics to microphysiological systems: Past, present, and future
TL;DR: For over a decade, we have seen significant strides in the microfluidics field that have led to the concept of microphysiological systems as discussed by the authors , and the main hallmarks of each of these periods and outline current and upcoming trends in the field of microPhysiological systems.
Journal ArticleDOI
Microphysiological model of renal cell carcinoma to inform anti-angiogenic therapy.
María Virumbrales-Muñoz,Jose M. Ayuso,Jack R. Loken,Kathryn M. Denecke,Shujah Rehman,Melissa C. Skala,E. Jason Abel,David J. Beebe +7 more
TL;DR: In this paper , a microphysiological model of renal cell carcinoma was presented, including a tubular blood vessel model of induced pluripotent stem cell-derived endothelial cells and an adjacent 3D carcinoma model.
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Recent Advances in Drug Delivery System Fabricated by Microfluidics for Disease Therapy
Fuhao Jia,Yan Gao,Hai Wang +2 more
TL;DR: In this paper , the authors describe the interaction of drugs with lymphatic vessels that are neglected in organs-on-chips and describe the accelerated development of microfluidics holds great potential for the clinical translation of micro/nanoparticle drug delivery systems for disease treatment.
Journal ArticleDOI
In vitro models for head and neck cancer: Current status and future perspective
Christian R. Moya-Garcia,Hideaki Okuyama,Nader Sadeghi,Jianyu Li,Maryam Tabrizian,Nicole Y K Li-Jessen +5 more
TL;DR: A review of the TME features of H&N cancer that are most relevant to in vitro drug evaluation, and a selection of advanced culture models, namely, spheroids, organotypic models, and microfluidic chips, in their applications for H &N cancer drug research.
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