Priming the Proteasome to Protect against Proteotoxicity
Xuejun Wang,Hongmin Wang +1 more
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TLDR
Recent research in proteasome biology reveals that the prote asome can be activated by endogenous protein kinases, making it possible to pharmacologically prime the proteasomes for treating diseases with IPTS.About:
This article is published in Trends in Molecular Medicine.The article was published on 2020-07-01 and is currently open access. It has received 13 citations till now. The article focuses on the topics: Proteotoxicity & Proteasome.read more
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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction
Bo Pan,Jie Li,Jie Li,Nirmal Parajuli,Zongwen Tian,Zongwen Tian,Penglong Wu,Penglong Wu,Megan T. Lewno,Jianqiu Zou,Wenjuan Wang,Wenjuan Wang,Lynn Bedford,R. John Mayer,Jing Fang,Jinbao Liu,Taixing Cui,Huabo Su,Huabo Su,Xuejun Wang +19 more
TL;DR: The activation of cardiac macroautophagy by proteasomal malfunction is mediated by the Mocln1-calcineurin-TFEB-p62 pathway, and targeting the Mcoln1 (mucolipin1)-cal cineur in-TF EB-p 62 pathway may provide new means to intervene cardiac autophagic-lysosomal pathway activation during proteasome malfunction.
Journal ArticleDOI
New roles for desmin in the maintenance of muscle homeostasis.
TL;DR: In this paper, the authors provide an overview of the structural and cellular roles of desmin and propose new models for its novel functions in preserving the homeostasis of striated muscles.
Journal ArticleDOI
Cellular Protein Quality Control in Diabetic Cardiomyopathy: From Bench to Bedside.
TL;DR: The function and regulation of cardiac PQC machinery in diabetes mellitus, and the therapeutic potential for the diabetic heart are discussed.
Journal ArticleDOI
COP9 Signalosome Suppresses RIPK1-RIPK3-Mediated Cardiomyocyte Necroptosis in Mice.
Peng Xiao,Changhua Wang,Jie Li,Jie Li,Huabo Su,Huabo Su,Liuqing Yang,Penglong Wu,Penglong Wu,Megan T. Lewno,Jinbao Liu,Xuejun Wang +11 more
TL;DR: Cardiac Cops8/COP9 signalosome malfunction causes RIPK1-RIPK3 dependent, but mitochondrial permeability transition pore independent, cardiomyocyte necroptosis in mice and the COP9 signalOSome plays an indispensable role in suppressing cardiomeocyte ne croptosis.
Additional file 1: Table S1. of A substitution mutation in cardiac ubiquitin ligase, FBXO32, is associated with an autosomal recessive form of dilated cardiomyopathy
Zuhair N. Al-Hassnan,Zarghuna M.A. Shinwari,Salma M. Wakil,Sahar Tulbah,Shamayel Mohammed,Zuhair Rahbeeni,Mohammed H. Alghamdi,Monther Rababh,Dilek Colak,N. Kaya,Majid Al-Fayyadh,Jehad Al-Buraiki +11 more
TL;DR: In this paper, a consanguineous family with four affected siblings with severe dilated cardiomyopathy was found to have a region of homozygosity (ROH) on chromosome 8q24.13−24.23 shared by all of the affected siblings.
References
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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Eiki Takimoto,Hunter C. Champion,Manxiang Li,Diego F. Belardi,Shuxun Ren,E. Rene Rodriguez,Djahida Bedja,Kathleen L. Gabrielson,Yibin Wang,David A. Kass +9 more
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The Logic of the 26S Proteasome
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