Journal ArticleDOI
Production of Active Compounds in Medicinal Plants: From Plant Tissue Culture to Biosynthesis
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TLDR
In order to improve the contents of active compounds in medicinal plants, following aspects could be carried out gene interference or gene silencing, gene overexpression, combination with chemical synthesis, application of elicitors, and site-directed mutagenesis of the key enzymes.About:
This article is published in Chinese Herbal Medicines.The article was published on 2017-04-01. It has received 36 citations till now. The article focuses on the topics: Plant tissue culture.read more
Citations
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Journal Article
Aluminum induced programed cell death of peanut suspension cultures detected by flow cytometry
TL;DR: There was a negative correlation between cell apoptpsis rate and Al- resistance of peanut and there were significant differences between the two peanut varieties.
Journal ArticleDOI
Exogenous NaCl salt elicitor improves centelloside content and physio-morphological adaptations in indian pennywort (Centella asiatica)
Piyanan Pipatsitee,Patchara Praseartkul,Cattarin Theerawitaya,Kanyaratt Taota,Rujira Tisarum,Haminder Pal Singh,Suriyan Cha-um +6 more
TL;DR: In this paper, the optimum NaCl elicitation for improving centellosides yield and associated physio-morphological adaptations in Indian pennywort (Centella asiatica (L.) Urban) was investigated.
Journal ArticleDOI
Production of secondary metabolites using tissue culture-based biotechnological applications
Ibrahim Ilker Ozyigit,Ilhan Dogan,Asli Hocaoglu-Ozyigit,Beste Yalcin,Ayşe Erdoğan,Ibrahim Ertugrul Yalcin,Evren Cabi,Y. Kaya +7 more
TL;DR: In this paper , the benefits of secondary metabolites and their production through tissue culture-based biotechnological applications are discussed using literature with presence of current studies, and some of them receiving attention are found to be taken place in plant biotechnology and having promising applications.
Journal ArticleDOI
Optimization of Machine Learning Model and Factor Analysis for Predicting the Active Ingredient Content of Medicinal Crops
TL;DR: In this article , the authors proposed a method to solve the problem of the lack of a suitable solution for the problem by using the concept of "blending" of the two parties.
Journal ArticleDOI
Chemical characterization and bioactivities of fructans from Pfaffia glomerata roots
TL;DR: In this article , the prebiotic and antioxidant potential of fructans from P. glomerata ex vitro roots and adventitious roots cultivated in vitro in a roller bottle system were evaluated.
References
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Journal ArticleDOI
High-level semi-synthetic production of the potent antimalarial artemisinin
Christopher J. Paddon,Patrick J. Westfall,Douglas J. Pitera,Kirsten R. Benjamin,Karl Fisher,Derek McPhee,Michael D. Leavell,Anna Tai,A. Main,Diana Eng,Devin R Polichuk,Keat H. Teoh,Darwin W. Reed,T. Treynor,Jacob R. Lenihan,Hanxiao Jiang,M. Fleck,S. Bajad,G. Dang,D. Dengrove,Don Diola,G. Dorin,Kenneth W. Ellens,Scott Fickes,J. Galazzo,Sara P. Gaucher,T. Geistlinger,Ronald Henry,M. Hepp,Tizita Horning,T. Iqbal,L. Kizer,B. Lieu,D. Melis,Nathan A. Moss,Rika Regentin,S. Secrest,H. Tsuruta,R. Vazquez,Lars F. Westblade,Lan Xu,M. Yu,Yansheng Zhang,Lishan Zhao,Jefferson C. Lievense,Patrick S. Covello,Jay D. Keasling,K. K. Reiling,N. S. Renninger,Jack D. Newman +49 more
TL;DR: The strains and processes described here form the basis of a viable industrial process for the production of semi-synthetic artemisinin to stabilize the supply of art Artemisinin for derivatization into active pharmaceutical ingredients (for example, artesunate) for incorporation into ACTs.
Journal Article
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli
Parayil Kumaran Ajikumar,Wen-Hai Xiao,Keith E. J. Tyo,Yong Wang,Fritz Simeon,Effendi Leonard,Oliver Mucha,Too Heng Phon,Blaine A. Pfeifer,Gregory Stephanopoulos +9 more
TL;DR: In this paper, a multivariate-modular approach to metabolic-pathway engineering that succeeded in increasing titers of taxadiene, the first committed Taxol intermediate, was reported.
Journal ArticleDOI
Distributing a metabolic pathway among a microbial consortium enhances production of natural products
TL;DR: Stable co-culture in the same bioreactor was achieved by designing a mutualistic relationship between the two species in which a metabolic intermediate produced by E. coli was used and functionalized by yeast.
Journal ArticleDOI
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli
Parayil Kumaran Ajikumar,Wen-Hai Xiao,Keith E. J. Tyo,Yong Wang,Fritz Simeon,Effendi Leonard,Oliver Mucha,Too Heng Phon,Blaine A. Pfeifer,Gregory Stephanopoulos,Gregory Stephanopoulos +10 more
TL;DR: A multivariate-modular approach to metabolic-pathway engineering that succeeded in increasing titers of taxadiene—the first committed Taxol intermediate—approximately 1 gram per liter in an engineered Escherichia coli strain helped to unlock the potential of the MEP pathway for the engineered production of terpenoid natural products.
Journal ArticleDOI
CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.
Juan Guo,Yongjin J. Zhou,Matthew L. Hillwig,Ye Shen,Lei Yang,Yajun Wang,Xianan Zhang,Wujun Liu,Reuben J. Peters,Xiao-Ya Chen,Zongbao K. Zhao,Huang Luqi +11 more
TL;DR: The results and the approaches that were described here provide a solid foundation to further elucidate the biosynthesis of tanshinones and related diterpenoids and should facilitate the construction of microbial cell factories for the production of phytoterpenoids.
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