Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.
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TLDR
A phylogenetic comparison of PCNA genes suggests that the multi-functionality observed in most species is a product of evolution.About:
This article is published in Annals of Botany.The article was published on 2011-05-01 and is currently open access. It has received 530 citations till now. The article focuses on the topics: Eukaryotic DNA replication & Proliferating cell nuclear antigen.read more
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Expressão da progranulina durante os primeiros estágios de desenvolvimento hepático em ratos Fischer 344
Arthur C. de L. Lima,Cristiane Carlin Passos,Amanda Olivotti Ferreira,Andrew Bateman,Maria Angélica Miglino,Ricardo Romão Guerra +5 more
TL;DR: O estudo teve como objetivo avaliar o papel do fator de crescimento progranulina (PGRN) durante o desenvolvimento hepatico em ratos F344, uma vez that a PGRN poderia ser utilizada em protocolos de diferenciacao de CT do broto hepatica em hepatocitos funcionais.
DissertationDOI
Potencial antitumoral do composto 7-epi-clusianona em linhagens celulares de câncer de mama humano cultivadas como monocamadas e esferoides.
TL;DR: Evaluated data suggest that 7-epi-clusianone is a promising molecule against tumor cells, which demonstrated antitumoral potential against breast cancer cells, and three-dimensional culture was more resistant to treatment with the compound than the monolayer.
Journal ArticleDOI
Effects of fecal bacteria on growth, digestive capacity, antioxidant capacity, intestinal health of large yellow croaker (Larimichthys crocea) larvae
Jianmin Zhang,Yuntao Wang,Jiahui Liu,Wen‐Xuan Xu,Zhaoyang Yin,Yongtao Liu,Zhen Wang,Ye Gong,Chuanwei Yao,Kangsen Mai,Qinghui Ai +10 more
TL;DR: In this paper , the authors examined how large yellow croaker larvae (Larimichthys crocea) (mean body weight 3.64 ± 0.20 mg) responde to fecal microbiota transplantation.
Journal ArticleDOI
Co-Delivery of Dexamethasone and Captopril by α8 Integrin Antibodies Modified Liposome-PLGA Nanoparticle Hybrids for Targeted Anti-Inflammatory/Anti-Fibrosis Therapy of Glomerulonephritis
TL;DR: In vivo pharmacodynamics showed that DXMS/CAP@PLGA-ILs can effectively improve the pathological changes in the mesangial area and positive expression of proliferating cell nuclear antigen in glomeruli as well as reduce the expression of inflammatory factors, fibrotic factors and reactive oxygen species (ROS).
Journal ArticleDOI
DR1 Activation Inhibits the Proliferation of Vascular Smooth Muscle Cells through Increasing Endogenous H<sub>2</sub>S in Diabetes
TL;DR: In this paper , the authors showed that the chronic complications of diabetes are related to the decrease of endogenous hydrogen sulfide (H2S) in diabetic patients, and it has been proven that H2S can inhibit the proliferation of vascular SMCs (VSMCs).
References
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WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
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p21 is a universal inhibitor of cyclin kinases
Yue Xiong,Gregory J. Hannon,Gregory J. Hannon,Hui Zhang,Hui Zhang,David J. Casso,David J. Casso,Ryuji Kobayashi,David Beach,David Beach +9 more
TL;DR: It is found that over expression of p21 inhibits the activity of each member of the cyclin/CDK family, and this results indicate that p21 may be a universal inhibitor of cyclin kinases.
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Inhibitors of mammalian G1 cyclin-dependent kinases.
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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
TL;DR: The molecular mechanisms of DNA repair and the DNA damage checkpoints in mammalian cells are analyzed and apoptosis, which eliminates heavily damaged or seriously deregulated cells, is analyzed.
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Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta.
TL;DR: Cyclin and the auxiliary protein of DNA polymerase-δ are identical, and it is reported here that these two are identical.
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