Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.
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TLDR
A phylogenetic comparison of PCNA genes suggests that the multi-functionality observed in most species is a product of evolution.About:
This article is published in Annals of Botany.The article was published on 2011-05-01 and is currently open access. It has received 530 citations till now. The article focuses on the topics: Eukaryotic DNA replication & Proliferating cell nuclear antigen.read more
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Alkaloid and acetogenin-rich fraction from Annona crassiflora fruit peel inhibits proliferation and migration of human liver cancer HepG2 cells.
Allisson Benatti Justino,Rodrigo M. Florentino,Andressa França,Antônio Lacerda Filho,Rodrigo Rodrigues Franco,André Lopes Saraiva,Matheus de Castro Fonseca,Maria de Fátima Leite,Foued Salmen Espindola +8 more
TL;DR: The results support the growth-inhibitory potential of AF-Ac on HepG2 cells and suggest that this effect is triggered, at least in part, by PCNA and EGFR modulation and mobilization of intracellular Ca2+.
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A Treatment Combination of IGF and EGF Promotes Hair Growth in the Angora Rabbit
TL;DR: In this article, a treatment combination of 10 ng/mL insulin-like growth factor-1 (IGF-1) and 20 n/mL epidermal growth factor (EGF) significantly increased the elongation length of hair shafts for cultured HFs.
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Quantitative proteomic analysis provides insights into the algicidal mechanism of Halobacillus sp. P1 against the marine diatom Skeletonema costatum.
TL;DR: A tandem mass tag (TMT)-based proteomic approach was coupled with physiological analysis to investigate the cellular responses of S. costatum when treated with P1 culture supernatant and provides new insights into algae-bacteria interactions.
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Arabidopsis thaliana: proliferating cell nuclear antigen 1 and 2 possibly form homo- and hetero-trimeric complexes in the plant cell.
TL;DR: In a bimolecular fluorescence complementation assay an interaction between PCNA1 and PCNA2 was observed in the nucleus, as well as in the cytoplasm, which indicates that PCNA 1 andPCNA2 may cooperate in planta by forming homo- and heterotrimeric rings.
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Effects of resveratrol on ARPE-19 cell proliferation and migration via regulating the expression of proliferating cell nuclear antigen, P21, P27 and p38MAPK/MMP-9.
TL;DR: Res can inhibit APRE-19 cell proliferation and migration in a concentration-dependent manner with up-regulation of the expression of P21 and P27, and down- regulation of PCNA, MMP-9 and p38MAPK.
References
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WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
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p21 is a universal inhibitor of cyclin kinases
Yue Xiong,Gregory J. Hannon,Gregory J. Hannon,Hui Zhang,Hui Zhang,David J. Casso,David J. Casso,Ryuji Kobayashi,David Beach,David Beach +9 more
TL;DR: It is found that over expression of p21 inhibits the activity of each member of the cyclin/CDK family, and this results indicate that p21 may be a universal inhibitor of cyclin kinases.
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Inhibitors of mammalian G1 cyclin-dependent kinases.
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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
TL;DR: The molecular mechanisms of DNA repair and the DNA damage checkpoints in mammalian cells are analyzed and apoptosis, which eliminates heavily damaged or seriously deregulated cells, is analyzed.
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Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta.
TL;DR: Cyclin and the auxiliary protein of DNA polymerase-δ are identical, and it is reported here that these two are identical.
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