Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.
Reads0
Chats0
TLDR
A phylogenetic comparison of PCNA genes suggests that the multi-functionality observed in most species is a product of evolution.About:
This article is published in Annals of Botany.The article was published on 2011-05-01 and is currently open access. It has received 530 citations till now. The article focuses on the topics: Eukaryotic DNA replication & Proliferating cell nuclear antigen.read more
Citations
More filters
Journal ArticleDOI
Elephantopus mollis Kunth extracts induce antiproliferation and apoptosis in human lung cancer and myeloid leukemia cells.
Truong Thi Bich Ngoc,Nguyen Thi Hoai Nga,Nguyen Thi My Trinh,Tran Linh Thuoc,Dang Thi Phuong Thao +4 more
TL;DR: The anticancer activity and associated molecular mechanism of EM which is distributed in Vietnam were investigated and the combination of antiproliferation and apoptosis activation contributed to the high efficacy of EM extracts.
Journal ArticleDOI
Effects of Cedrus atlantica extract on acute myeloid leukemia cell cycle distribution and apoptosis.
Pei-Hsiu Hung,Ming-Chang Hsieh,Shan-Chih Lee,Xiao-Fan Huang,Kai-Fu Chang,Szu-Yin Chen,Ming-Shih Lee,Nu-Man Tsai +7 more
TL;DR: CAt extract treatment significantly reduced cell growth, cell cycle arrest in the G0/G1 phase, and induction of apoptosis, leading to leukemia cell death, demonstrating an inhibitory effect on human leukemia cells.
Journal ArticleDOI
Gene commander in the trash heap: Transcriptional regulation and ubiquitination modification mediated by RNF6 in carcinogenesis
TL;DR: In this article, the role of RNF6 ubiquitination in various physiological and pathological mechanisms, such as Akt/mTOR signaling pathway, Wnt/β-catenin pathway, RNF 6/ERα/Bcl-xL axis, and provides knowledge and understanding for the treatment of diseases.
Dissertation
Investigating the role of specific inflammasome components during inflammatory disease
TL;DR: The findings suggest that a patient presenting with Blau-like autoinflammatory symptoms has a rare loss-of-function NLRP6R653G mutation, which is responsible for the patient?s sustained inflammatory symptoms.
Posted ContentDOI
Scalable Phylogenetic Profiling using MinHash Uncovers Likely Eukaryotic Sexual Reproduction Genes
TL;DR: This work introduces a fast, scalable phylogenetic profiling approach entitled HogProf, which leverages hierarchical orthologous groups for the construction of large profiles and locality-sensitive hashing for efficient retrieval of similar profiles, and shows that the approach outperforms Enhanced Phylogenetic Tree.
References
More filters
Journal ArticleDOI
WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
Journal ArticleDOI
p21 is a universal inhibitor of cyclin kinases
Yue Xiong,Gregory J. Hannon,Gregory J. Hannon,Hui Zhang,Hui Zhang,David J. Casso,David J. Casso,Ryuji Kobayashi,David Beach,David Beach +9 more
TL;DR: It is found that over expression of p21 inhibits the activity of each member of the cyclin/CDK family, and this results indicate that p21 may be a universal inhibitor of cyclin kinases.
Journal ArticleDOI
Inhibitors of mammalian G1 cyclin-dependent kinases.
Journal ArticleDOI
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
TL;DR: The molecular mechanisms of DNA repair and the DNA damage checkpoints in mammalian cells are analyzed and apoptosis, which eliminates heavily damaged or seriously deregulated cells, is analyzed.
Journal ArticleDOI
Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta.
TL;DR: Cyclin and the auxiliary protein of DNA polymerase-δ are identical, and it is reported here that these two are identical.
Related Papers (5)
PCNA, the Maestro of the Replication Fork
Proliferating cell nuclear antigen (PCNA): a dancer with many partners.
Giovanni Maga,Ulrich Hübscher +1 more