Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation.
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TLDR
A phylogenetic comparison of PCNA genes suggests that the multi-functionality observed in most species is a product of evolution.About:
This article is published in Annals of Botany.The article was published on 2011-05-01 and is currently open access. It has received 530 citations till now. The article focuses on the topics: Eukaryotic DNA replication & Proliferating cell nuclear antigen.read more
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Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway.
Tao Li,Chunfu Zhang,Yanling Ding,Wei Zhai,Kui Liu,Fan Bu,Tao Tu,Lingxian Sun,Wei Zhu,Fangfang Zhou,Wenkai Qi,Jiabo Hu,Huabiao Chen,Xiaochun Sun +13 more
TL;DR: The findings showed that UC-MSC-CM promoted the proliferation and migration of breast cancer cell lines via activation of the ERK pathway, and U0126, an inhibitor of ERK, reversed the effects of UC- MSCs.
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DNA Base Excision Repair in Plants: An Unfolding Story With Familiar and Novel Characters.
Teresa Roldán-Arjona,Rafael R. Ariza,Rafael R. Ariza,Dolores Córdoba-Cañero,Dolores Córdoba-Cañero +4 more
TL;DR: Plant BER plays an important role in preserving genome integrity through removal of damaged bases, however, it performs additional important functions, such as the replacement of the naturally modified base 5-methylcytosine with cytosine in a plant-specific pathway for active DNA demethylation.
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Hydroxytyrosol from olive fruits prevents blue-light-induced damage in human keratinocytes and fibroblasts.
Rosanna Avola,Adriana Carol Eleonora Graziano,Giovanna Pannuzzo,Francesco Bonina,Venera Cardile +4 more
TL;DR: It is demonstrated that hydroxytyrosol protects keratinocytes and fibroblasts from LED‐BL‐induced damage and might be proposed as an encouraging candidate for the prevention of BL‐induced premature photoaging.
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Multi-Therapeutic Potential of Naringenin (4',5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms.
Azher Arafah,Muneeb U. Rehman,Tahir Maqbool Mir,Adil Farooq Wali,Rayeesa Ali,Wajhul Qamar,Rehan Khan,Ajaz Ahmad,Syed Sameer Aga,Saeed Alqahtani,Nada M Almatroudi +10 more
TL;DR: Various pharmacological activities of naringenin, such as anticancer, antidiabetic, hepatoprotective, neuroprotective, cardioprotective and nephroprotective effects, have been discussed along with their mechanisms of action.
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Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration.
Bradley J. Walters,Jian Zuo +1 more
TL;DR: The pursuit of regeneration in the postnatal and adult mouse cochlea is focused on and processes that occur during postnatal development, maturation, and aging are highlighted that could contribute to an age-related decline in regenerative potential.
References
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WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
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p21 is a universal inhibitor of cyclin kinases
Yue Xiong,Gregory J. Hannon,Gregory J. Hannon,Hui Zhang,Hui Zhang,David J. Casso,David J. Casso,Ryuji Kobayashi,David Beach,David Beach +9 more
TL;DR: It is found that over expression of p21 inhibits the activity of each member of the cyclin/CDK family, and this results indicate that p21 may be a universal inhibitor of cyclin kinases.
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Inhibitors of mammalian G1 cyclin-dependent kinases.
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Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
TL;DR: The molecular mechanisms of DNA repair and the DNA damage checkpoints in mammalian cells are analyzed and apoptosis, which eliminates heavily damaged or seriously deregulated cells, is analyzed.
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Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta.
TL;DR: Cyclin and the auxiliary protein of DNA polymerase-δ are identical, and it is reported here that these two are identical.
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