Journal ArticleDOI
Proteomic phenotyping: metastatic and invasive breast cancer
TLDR
Comparisons with available two-dimensional gel electrophoresis maps in the literature indicate that MCF-7/ADR has a protein expression signature even closer to of the ductal infiltrating breast carcinoma cell line 8701, which might have originated in a selection of ductal infiltrated carcinoma cells.About:
This article is published in Cancer Letters.The article was published on 2004-07-16. It has received 35 citations till now. The article focuses on the topics: CA15-3 & Breast cancer.read more
Citations
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American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer
Lyndsay Harris,Herbert A. Fritsche,Robert G. Mennel,Larry Norton,Peter M. Ravdin,Sheila E. Taube,Mark R. Somerfield,Daniel F. Hayes,Robert C. Bast +8 more
TL;DR: Thirteen categories of breast tumor markers were considered, six of which were new for the guideline, and certain multiparameter gene expression assays not all applications for these markers were supported, however.
Journal ArticleDOI
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer
Lyndsay Harris,Herbert A. Fritsche,Robert G. Mennel,Larry Norton,Peter M. Ravdin,Sheila E. Taube,Mark R. Somerfield,Daniel F. Hayes,Robert C. Bast +8 more
TL;DR: Thirteen categories of breast tumor markers were considered, six of which were new for the guideline, and not all applications for these markers were supported, however.
Journal ArticleDOI
A case study in misidentification of cancer cell lines: MCF-7/AdrR cells (re-designated NCI/ADR-RES) are derived from OVCAR-8 human ovarian carcinoma cells
Mordechai Liscovitch,Dana Ravid +1 more
TL;DR: The results of these analyses show that NCI/ADR-RES cells are derived from OVCAR-8 ovarian adenocarcinoma cells, highlighting a wide-spread problem of cell line cross-contamination and misidentification.
Journal ArticleDOI
Proteomics of breast carcinoma
TL;DR: Laser microdissection, a method for selection of homogenous cell populations, coupled to 2D-DIGE or MudPIT constitute a new proteomics-based paradigm for detecting disease in pathology specimens and monitoring disease response to therapy.
Journal ArticleDOI
Proteomic analysis of tumor necrosis factor-α resistant human breast cancer cells reveals a MEK5/Erk5-mediated epithelial-mesenchymal transition phenotype
Changhua Zhou,Changhua Zhou,Ashley M. Nitschke,Wei Xiong,Qiang Zhang,Yan Tang,Michael Bloch,Steven Elliott,Yun Zhu,Lindsey E. Bazzone,David C. Yu,David C. Yu,Christopher B. Weldon,Rachel Schiff,John A. McLachlan,Barbara S. Beckman,Thomas E. Wiese,Kenneth P. Nephew,Bin Shan,Matthew E. Burow,Guangdi Wang +20 more
TL;DR: This study demonstrates that MEK5 over-expression promotes a TNF-α resistance phenotype associated with distinct proteomic changes (upregulation of VIM/vim, GSTP1/gstp1, and CKB/ckb; and downregulation of KRT8/krt8, KRT19/kRT19, and GSTM3/gStm3).
References
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Journal ArticleDOI
A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma
Journal ArticleDOI
A multidrug resistance transporter from human MCF-7 breast cancer cells
L. Austin Doyle,Weidong Yang,Lynne V. Abruzzo,Tammy Krogmann,Y. Gao,Arun K. Rishi,Douglas D. Ross,Douglas D. Ross +7 more
TL;DR: In this article, the authors identify a 2.4-kb mRNA that encodes a 663-aa member of the ATP-binding cassette superfamily of transporters that they termed breast cancer resistance protein (BCRP).
Journal ArticleDOI
Systematic variation in gene expression patterns in human cancer cell lines.
Douglas T. Ross,Uwe Scherf,Michael B. Eisen,Charles M. Perou,Christian A. Rees,Paul T. Spellman,Vishwanath R. Iyer,Stefanie S. Jeffrey,Matt van de Rijn,Mark Waltham,Alexander Pergamenschikov,Jeffrey C. Lee,Deval A. Lashkari,Dari Shalon,Timothy G. Myers,John N. Weinstein,David Botstein,Patrick O. Brown +17 more
TL;DR: Using cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-cancer drugs provided a novel molecular characterization of this important group of human cell lines and their relationships to tumours in vivo.
Journal ArticleDOI
Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells.
Gerald Batist,A Tulpule,Birandra K. Sinha,Aspandiar G. Katki,Charles E. Myers,Kenneth H. Cowan +5 more
TL;DR: The overexpression of a similar anionic glutathione transferase in human breast cancer cells selected for multidrug resistance and in rat hyperplastic liver nodules, which develop resistance to various hepatotoxins, suggests a possible role for this drug-conjugating enzyme in the mechanism of resistance in both of these states.
Journal Article
Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice.
TL;DR: The results suggest that the estrogen receptor-negative MDA-MB-435 cell line injected into nude mice is a favorable site for the growth of human breast carcinomas and could be a valuable tool for analysis of the cellular and molecular basis of the metastasis of advanced breast cancer.
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