Quantitative analysis of hyperpolarized 129Xe ventilation imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease
Rohan S. Virgincar,Zackary I. Cleveland,S. Sivaram Kaushik,Matthew S. Freeman,John Nouls,Gary P. Cofer,Santiago Martinez-Jimenez,Mu He,Monica Kraft,Jan Wolber,Jan Wolber,H. Page McAdams,Bastiaan Driehuys +12 more
TLDR
V ventilation histograms and their associated CVs distinguished between subjects with COPD with similar ventilation defect scores, but visibly different ventilation patterns, and heterogeneity was analyzed using the coefficient of variation (CV).Abstract:
In this study, hyperpolarized 129Xe MR ventilation and 1H anatomical images were obtained from three subject groups: young healthy volunteers (HVs), subjects with chronic obstructive pulmonary disease (COPD) and age-matched controls (AMCs). Ventilation images were quantified by two methods: an expert reader-based ventilation defect score percentage (VDS%) and a semi-automated segmentation-based ventilation defect percentage (VDP). Reader-based values were assigned by two experienced radiologists and resolved by consensus. In the semi-automated analysis, 1H anatomical images and 129Xe ventilation images were both segmented following registration to obtain the thoracic cavity volume and ventilated volume, respectively, which were then expressed as a ratio to obtain the VDP. Ventilation images were also characterized by generating signal intensity histograms from voxels within the thoracic cavity volume, and heterogeneity was analyzed using the coefficient of variation (CV). The reader-based VDS% correlated strongly with the semi-automatically generated VDP (r = 0.97, p < 0.0001) and with CV (r = 0.82, p < 0.0001). Both 129Xe ventilation defect scoring metrics readily separated the three groups from one another and correlated significantly with the forced expiratory volume in 1 s (FEV1) (VDS%: r = –0.78, p = 0.0002; VDP: r = –0.79, p = 0.0003; CV: r = –0.66, p = 0.0059) and other pulmonary function tests. In the healthy subject groups (HVs and AMCs), the prevalence of ventilation defects also increased with age (VDS%: r = 0.61, p = 0.0002; VDP: r = 0.63, p = 0.0002). Moreover, ventilation histograms and their associated CVs distinguished between subjects with COPD with similar ventilation defect scores, but visibly different ventilation patterns. Copyright © 2012 John Wiley & Sons, Ltd.read more
Citations
More filters
Journal ArticleDOI
Regional Ventilation Changes in Severe Asthma after Bronchial Thermoplasty with 3He MR Imaging and CT
Robert P. Thomen,Robert P. Thomen,Ajay Sheshadri,James D. Quirk,Jim Kozlowski,Henry Ellison,Rhonda D. Szczesniak,Mario Castro,Jason C. Woods,Jason C. Woods +9 more
TL;DR: This paper quantified regional lung ventilation in healthy volunteers and patients with severe asthma at the level of individual bronchopulmonary segments by using a combination of 3He MR imaging and CT.
Journal ArticleDOI
Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.
S. Sivaram Kaushik,Scott H. Robertson,Matthew S. Freeman,Mu He,Kevin T. Kelly,Justus E. Roos,Craig R. Rackley,W. Michael Foster,H. Page McAdams,Bastiaan Driehuys +9 more
TL;DR: A clinically feasible 1‐point Dixon, three‐dimensional radial acquisition strategy to create isotropic 3D MR images of 129Xe in the airspaces, barrier, and red blood cells (RBCs) in a single breath is developed and tested.
Journal ArticleDOI
Functional imaging of the lungs with gas agents.
Stanley J. Kruger,Scott K. Nagle,Marcus J. Couch,Yoshiharu Ohno,Mitchell S. Albert,Sean B. Fain +5 more
TL;DR: This review focuses on the state‐of‐the‐art of the three major classes of gas contrast agents used in magnetic resonance imaging (MRI)—hyperpolarized (HP) gas, molecular oxygen, and fluorinated gas—and their application to clinical pulmonary research.
Journal ArticleDOI
Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.
S. Sivaram Kaushik,Matthew S. Freeman,Suk W. Yoon,Maria Liljeroth,Jane V. Stiles,Justus E. Roos,W. Sivaram Michael Foster,Craig R. Rackley,H P McAdams,Bastiaan Driehuys +9 more
TL;DR: This work hypothesized that in patients with idiopathic pulmonary fibrosis (IPF), the ratio of (129)Xe spectroscopic signal in the RBCs vs. barrier would diminish as diffusion-limitation delayed replenishment of ( 129) Xe magnetization in RBC’s.
Journal ArticleDOI
Feasibility, tolerability and safety of pediatric hyperpolarized (129)Xe magnetic resonance imaging in healthy volunteers and children with cystic fibrosis.
Laura L. Walkup,Robert P. Thomen,Robert P. Thomen,Teckla G. Akinyi,Teckla G. Akinyi,Erin Watters,Kai Ruppert,John P. Clancy,Jason C. Woods,Jason C. Woods,Zackary I. Cleveland,Zackary I. Cleveland +11 more
TL;DR: Hyperpolarized 129Xe MRI has been assessed in a small group of children as young as 6 years and shows that it is a safe and well-tolerated inhaled contrast agent for pulmonary MR imaging in healthy children and in children with cystic fibrosis who have mild to moderate lung disease.
References
More filters
Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Closed-form solution of absolute orientation using unit quaternions
TL;DR: A closed-form solution to the least-squares problem for three or more paints is presented, simplified by use of unit quaternions to represent rotation.
Book
Chronic obstructive pulmonary disease
TL;DR: The most important bacterial causes of exacerbations of COPD are nontypeable Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pneumoniae and Chlamydia pneumoniae.
Journal ArticleDOI
Chronic obstructive pulmonary disease phenotypes: the future of COPD.
MeiLan K. Han,Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Gerard J. Criner,Jeffrey L. Curtis,Leonardo M. Fabbri,Jonathan G. Goldin,Paul W. Jones,William MacNee,Barry J. Make,Klaus F. Rabe,Stephen I. Rennard,Frank C. Sciurba,Edwin K. Silverman,Jørgen Vestbo,George R. Washko,Emiel F.M. Wouters,Fernando J. Martinez +18 more
TL;DR: This work proposes the following variation on this definition of COPD phenotypes: "a single or combination of disease attributes that describe differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death)."