Journal ArticleDOI
Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug delivery.
TLDR
The results indicate the potential of Fe(3)O(4)@SiO(2) hollow mesoporous spheres for drug loading and delivery into cancer cells to induce cell death.Abstract:
Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres with different particle sizes, different mesoporous shell thicknesses, and different levels of Fe(3)O(4) content are prepared by using carbon spheres as templates. The effects of particle size and concentration of Fe(3)O(4)@SiO(2) hollow mesoporous spheres on cell uptake and their in vitro cytotoxicity to HeLa cells are evaluated. The spheres exhibit relatively fast cell uptake. Concentrations of up to 150 microg mL(-1) show no cytotoxicity, whereas a concentration of 200 microg mL(-1) shows a small amount of cytotoxicity after 48 h of incubation. Doxorubicin hydrochloride (DOX), an anticancer drug, is loaded into the Fe(3)O(4)@SiO(2) hollow mesoporous spheres, and the DOX-loaded spheres exhibit a somewhat higher cytotoxicity than free DOX. These results indicate the potential of Fe(3)O(4)@SiO(2) hollow mesoporous spheres for drug loading and delivery into cancer cells to induce cell death.read more
Citations
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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
Journal ArticleDOI
Functionalized mesoporous silica materials for controlled drug delivery
TL;DR: This review highlights the most recent research progress on silica-based controlled drug delivery systems, including pure mesoporous silica sustained-release systems, magnetism and/or luminescence functionalized mesoporus silica systems which integrate targeting and tracking abilities of drug molecules.
Journal ArticleDOI
Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications.
TL;DR: This review focuses on the recent development and various strategies in the preparation, microstructure, and magnetic properties of bare and surface functionalized iron oxide nanoparticles (IONPs); their corresponding biological application was also discussed.
Journal ArticleDOI
Mesoporous silica nanoparticles in drug delivery and biomedical applications
Ying Wang,Qinfu Zhao,Ning Han,Ling Bai,Jia Li,Jia Liu,Erxi Che,Liang Hu,Qiang Zhang,Tongying Jiang,Siling Wang +10 more
TL;DR: A comprehensive review presents recent advances in mesoporous silica nanoparticles assisted drug delivery systems, including both immediate and sustained delivery systems as well as controlled release and targeted drug Delivery systems.
Journal ArticleDOI
Yolk/shell nanoparticles: new platforms for nanoreactors, drug delivery and lithium-ion batteries.
TL;DR: An overview of advances in the synthesis of YSNs with controllable sizes, compositions, geometries, structures and functionalities is provided, covering systematic synthesis approaches and key promising applications.
References
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Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism
TL;DR: In this paper, the synthesis of mesoporous inorganic solids from calcination of aluminosilicate gels in the presence of surfactants is described, in which the silicate material forms inorganic walls between ordered surfactant micelles.
Journal ArticleDOI
Colloidal carbon spheres and their core/shell structures with noble-metal nanoparticles.
Xiaoming Sun,Yadong Li +1 more
TL;DR: Only amorphous silica and some colloidal polymer spheres can be routinely prepared with satisfactorily narrow size distributions, and surface modification almost unavoidable before use as supports or templates.
Journal ArticleDOI
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery
Monty Liong,Jie Lu,Michael Kovochich,Tian Xia,Stefan G. Ruehm,Andre E. Nel,Fuyuhiko Tamanoi,Jeffrey I. Zink +7 more
TL;DR: In this article, superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation.
Journal ArticleDOI
Micellar nanocarriers: pharmaceutical perspectives.
TL;DR: This review will discuss some recent trends in using micelles as pharmaceutical carriers, including lipid-core micells, which may become the imaging agents of choice in different imaging modalities.
Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug
Delivery Liong,Jie Lu,Michael Kovochich,Tian Xia,Stefan G. Ruehm,Andre E. Nel,Fuyuhiko Tamanoi,Jeffrey I. Zink +7 more
TL;DR: Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts.