Journal ArticleDOI
Reactive oxygen species and cancer paradox: To promote or to suppress?
Sehamuddin Galadari,Sehamuddin Galadari,Anees Rahman,Siraj Pallichankandy,Faisal Thayyullathil +4 more
TLDR
This review focuses on the current understanding of the tumor promoting and the tumor suppressive functions of ROS, and highlights the potential mechanism(s) involved, and sheds light on a very novel and an actively growing field of ROS‐dependent cell death mechanism referred to as ferroptosis.About:
This article is published in Free Radical Biology and Medicine.The article was published on 2017-03-01. It has received 666 citations till now. The article focuses on the topics: Cancer stem cell & Cancer cell.read more
Citations
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Glutathione metabolism in cancer progression and treatment resistance.
Ankita Bansal,M. Celeste Simon +1 more
TL;DR: Recent studies that focus on deciphering the role of GSH in tumor initiation and progression as well as mechanisms underlying how GSH imparts treatment resistance to growing cancers are discussed.
Journal ArticleDOI
ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells
Anastasiya V. Snezhkina,Anna V. Kudryavtseva,Olga L. Kardymon,Maria V Savvateeva,Nataliya V. Melnikova,George S. Krasnov,Alexey A. Dmitriev +6 more
TL;DR: This review covers the current data on the mechanisms of ROS generation and existing antioxidant systems balancing the redox state in mammalian cells that can also be related to tumors.
Journal ArticleDOI
Reactive Oxygen Species and Mitochondrial Dynamics: The Yin and Yang of Mitochondrial Dysfunction and Cancer Progression
TL;DR: The latest findings on the intricate relationship between mitochondrial dynamics and ROS production are reviewed, focusing mainly on its role in malignant disease.
Journal ArticleDOI
Melatonin, a Full Service Anti-Cancer Agent: Inhibition of Initiation, Progression and Metastasis.
Russel J. Reiter,Sergio Rosales-Corral,Dun Xian Tan,Darío Acuña-Castroviejo,Lilan Qin,Shun-Fa Yang,Kexin Xu +6 more
TL;DR: The experimental findings suggest that the advantages of using melatonin as a co-treatment with conventional cancer therapies would far exceed improvements in the wellbeing of the patients.
Journal ArticleDOI
Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells.
Farhan Basit,Lisanne M.P.E. van Oppen,Laura Schöckel,Hasse M Bossenbroek,Sjenet E. van Emst-de Vries,Johannes Cw Hermeling,Sander Grefte,Sander Grefte,Charlotte Christine Kopitz,Mélanie Héroult,Peter H.G.M. Willems,Werner J.H. Koopman +11 more
TL;DR: A chain of events is proposed in which CI inhibition induces mPTP opening and Δψ depolarization, that stimulate autophagosome formation, mitophagy and an associated ROS increase, leading to activation of combined necroptotic/ferroptotic cell death.
References
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Journal ArticleDOI
The biochemistry of apoptosis
TL;DR: The basic components of the death machinery are reviewed, how they interact to regulate apoptosis in a coordinated manner is described, and the main pathways that are used to activate cell death are discussed.
Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
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The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.
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ROS Function in Redox Signaling and Oxidative Stress
TL;DR: It is argued that redox biology, rather than oxidative stress, underlies physiological and pathological conditions.
Journal ArticleDOI
Bioavailability of curcumin: problems and promises.
TL;DR: Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.