Journal ArticleDOI
Recent Advances in Lipid-Based Nanovesicular Delivery Systems for Melanoma Therapy
Mallesh Kurakula,Li Chen,Amit K. Tiwari,Nuggehally R. Srinivas,Ranjeet P Dash,Peter Panizzi,Robert D. Arnold,R. Jayachandra Babu +7 more
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TLDR
Various lipid-based nano-formulations used in the diagnosis, treatment, or both for melanoma are discussed and a state-of-the-art overview of alternative therapeutic approaches for the treatment of melanoma, such as photodynamic, immune, and gene therapies are presented.Abstract:
Melanoma is one of the most aggressive forms of cancer with limited treatment options available. Successful treatment involves a combination of surgical resection of the tumor; chemotherapy and immunotherapy. Given their complex nature, the rapid development of drug resistance and metastatic spread, nanotechnology-based therapeutics are an attractive option for effective melanoma treatment. Nano-vesicular-based delivery systems hold the promise of aiding in the diagnosis and treatment of melanoma. These formulations can improve targeted delivery, deliver insoluble drugs belonging to class II, biopharmaceutical classification system, and alter drug pharmacokinetics and exposure profiles. These nanometer-sized carriers predominantly bypass the reticuloendothelial system and, thereby, improve blood circulation time and enhance tumor cell uptake with reduced toxicity. In this review, various lipid-based nano-formulations used in the diagnosis, treatment, or both for melanoma are discussed. Utilization of these na-no-formulations with a single drug or a combination of drugs, nucleic acid-based compounds (small interfering RNA, DNA) and targeting antibodies as other possibilities for melanoma are reviewed. We also present a state-of-the-art overview of alternative therapeutic approaches for the treatment of melanoma, such as photodynamic, immune, and gene therapies.read more
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Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities.
Rabin Neupane,Sai H.S. Boddu,Mariam Sami Abou-Dahech,Rinda Devi Bachu,David Terrero,R. Jayachandra Babu,Amit K. Tiwari +6 more
TL;DR: In this paper, the authors discuss the advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs and also discuss a possible in silico approach, Formulating for Efficacy™, to design trans-dermal formulations that would probably be economical, robust, and more efficacious.
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Melanoma and Nanotechnology-Based Treatment
TL;DR: Current nanosystems used in the diagnosis and treatment of melanoma are discussed, including lipid systems, inorganic nanoparticles, polymeric systems, and natural nanosSystems.
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Bacterial cellulose-based composites as vehicles for dermal and transdermal drug delivery: A review.
TL;DR: A review of different types of dermal/transdermal DDSs, along with a critical discussion of the advantages and disadvantages of these systems can be found in this article .
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Targeted nanoscale drug delivery systems for melanoma therapy
Lanlan Fan,Zheng Wang,Dunyun Shi +2 more
TL;DR: In this article , a review highlights recent advances in targeted nanoparticle drug delivery systems for melanoma therapy, which encourage drug accumulation at the tumor site, enhance antitumor efficacy, and reduce systemic toxicity.
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Amino acid coordination complex mediates cisplatin entrapment within PEGylated liposome: an implication in colorectal cancer therapy.
Elaheh Mirhadi,Fatemeh Gheybi,Nadia Mahmoudi,Maliheh Hemmati,Fatemeh Soleimanian,Atefeh Ghasemi,Anis Askarizadeh,Mehrdad Iranshahi,Mahmoud Reza Jaafari,Seyedeh Hoda Alavizadeh +9 more
TL;DR: In this paper , a novel approach was developed for CDDP encasement within liposome based on the formation of a coordination bond between the platinum (II) atom and a carboxylic group in aspartic acid (AA) and glutamic acid (GA).
References
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Flávia Amanda Pedroso de Morais,Renato Sonchini Gonçalves,Bruno H. Vilsinski,Évelin Lemos de Oliveira,Nicola Leone da Rocha,Noboru Hioka,Wilker Caetano +6 more
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Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma
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A comparative ex vivo permeation evaluation of a novel 5-Fluorocuracil nanoemulsion-gel by topically applied in the different excised rat, goat, and cow skin.
Niyaz Ahmad,Rizwan Ahmad,Taysser Mohammed Buheazaha,Hussain Salman AlHomoud,Hassan Ali Al-Nasif,Sarafroz +5 more
TL;DR: 5-FU-NE-Gel is found to be for the better to treatment of cutaneous malignancies and could be a promising vehicle for the skin cancer chemoprevention.
Journal ArticleDOI
A peptide-modified solid lipid nanoparticle formulation of paclitaxel modulates immunity and outperforms dacarbazine in a murine melanoma model
Indranil Banerjee,Indranil Banerjee,Manjarika De,Goutam Dey,Rashmi Bharti,Sankha Chattopadhyay,Nahid Ali,Partha Chakrabarti,Rui L. Reis,Subhas C. Kundu,Mahitosh Mandal +10 more
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