Journal ArticleDOI
Recent Advances in Lipid-Based Nanovesicular Delivery Systems for Melanoma Therapy
Mallesh Kurakula,Li Chen,Amit K. Tiwari,Nuggehally R. Srinivas,Ranjeet P Dash,Peter Panizzi,Robert D. Arnold,R. Jayachandra Babu +7 more
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TLDR
Various lipid-based nano-formulations used in the diagnosis, treatment, or both for melanoma are discussed and a state-of-the-art overview of alternative therapeutic approaches for the treatment of melanoma, such as photodynamic, immune, and gene therapies are presented.Abstract:
Melanoma is one of the most aggressive forms of cancer with limited treatment options available. Successful treatment involves a combination of surgical resection of the tumor; chemotherapy and immunotherapy. Given their complex nature, the rapid development of drug resistance and metastatic spread, nanotechnology-based therapeutics are an attractive option for effective melanoma treatment. Nano-vesicular-based delivery systems hold the promise of aiding in the diagnosis and treatment of melanoma. These formulations can improve targeted delivery, deliver insoluble drugs belonging to class II, biopharmaceutical classification system, and alter drug pharmacokinetics and exposure profiles. These nanometer-sized carriers predominantly bypass the reticuloendothelial system and, thereby, improve blood circulation time and enhance tumor cell uptake with reduced toxicity. In this review, various lipid-based nano-formulations used in the diagnosis, treatment, or both for melanoma are discussed. Utilization of these na-no-formulations with a single drug or a combination of drugs, nucleic acid-based compounds (small interfering RNA, DNA) and targeting antibodies as other possibilities for melanoma are reviewed. We also present a state-of-the-art overview of alternative therapeutic approaches for the treatment of melanoma, such as photodynamic, immune, and gene therapies.read more
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Transdermal Delivery of Chemotherapeutics: Strategies, Requirements, and Opportunities.
Rabin Neupane,Sai H.S. Boddu,Mariam Sami Abou-Dahech,Rinda Devi Bachu,David Terrero,R. Jayachandra Babu,Amit K. Tiwari +6 more
TL;DR: In this paper, the authors discuss the advantages of transdermal route over oral and parenteral routes for popular chemotherapeutic drugs and also discuss a possible in silico approach, Formulating for Efficacy™, to design trans-dermal formulations that would probably be economical, robust, and more efficacious.
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Melanoma and Nanotechnology-Based Treatment
TL;DR: Current nanosystems used in the diagnosis and treatment of melanoma are discussed, including lipid systems, inorganic nanoparticles, polymeric systems, and natural nanosSystems.
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Bacterial cellulose-based composites as vehicles for dermal and transdermal drug delivery: A review.
TL;DR: A review of different types of dermal/transdermal DDSs, along with a critical discussion of the advantages and disadvantages of these systems can be found in this article .
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Targeted nanoscale drug delivery systems for melanoma therapy
Lanlan Fan,Zheng Wang,Dunyun Shi +2 more
TL;DR: In this article , a review highlights recent advances in targeted nanoparticle drug delivery systems for melanoma therapy, which encourage drug accumulation at the tumor site, enhance antitumor efficacy, and reduce systemic toxicity.
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Amino acid coordination complex mediates cisplatin entrapment within PEGylated liposome: an implication in colorectal cancer therapy.
Elaheh Mirhadi,Fatemeh Gheybi,Nadia Mahmoudi,Maliheh Hemmati,Fatemeh Soleimanian,Atefeh Ghasemi,Anis Askarizadeh,Mehrdad Iranshahi,Mahmoud Reza Jaafari,Seyedeh Hoda Alavizadeh +9 more
TL;DR: In this paper , a novel approach was developed for CDDP encasement within liposome based on the formation of a coordination bond between the platinum (II) atom and a carboxylic group in aspartic acid (AA) and glutamic acid (GA).
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Journal Article
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Mitsuhiro Mukaiya,Koichi Hirata,Tarumi K,Takeshi Takashima,Fumitake Hata,Denno R,Koito K,S. Takahashi,Masaaki Satoh +8 more
TL;DR: A case of resection performed for local recurrent tumors of primary malignant melanoma of the esophagus (PMME) is presented and it is found that the focal areas expressed S-100 protein and HMB-45 antibody.
Journal ArticleDOI
Rose Bengal-Amphiphilic Peptide Conjugate for Enhanced Photodynamic Therapy of Malignant Melanoma.
Simanpreet Kaur Dhillon,Simon L Porter,Nermeen Rizk,Yingjie Sheng,Thomas McKaig,Kathyrn Burnett,Bronagh White,Heather Nesbitt,Rubeta N Matin,Anthony P. McHale,Bridgeen Callan,John F. Callan +11 more
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