Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities
TLDR
Recent progress in the chemistry and biology of these diverse microtubule stabilizers focusing on the wide range of organisms that produce these compounds, their mechanisms of inhibiting microtubules-dependent processes, mechanisms of drug resistance, and their interactions with tubulin including their distinct binding sites and modes are covered.About:
This article is published in Natural Product Reports.The article was published on 2014-02-11 and is currently open access. It has received 113 citations till now.read more
Citations
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Journal ArticleDOI
Chemotherapy-Induced Peripheral Neuropathy and Changes in Cytoskeleton
TL;DR: This review will focus on highlighting the fundamental role of the crosstalk among the three filamentous subsystems and investigating pivotal cytoskeleton-associated proteins.
Journal ArticleDOI
Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads
TL;DR: Zampanolide and its structural relative dactylolide are promising new tubulin-assembly agents with the potential to become new anticancer drugs and this review covers their sources and isolation, structures, anticancer potential, mechanism of action, and syntheses.
Book ChapterDOI
Clinical Development of Anti-mitotic Drugs in Cancer.
TL;DR: The current knowledge of mitosis targeting agents that have been tested so far in the clinics is reviewed to help in identifying potent biomarkers predictive for response.
Journal Article
Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time.
TL;DR: The interphase actions of MTAs are critical to the full spectrum of their effects in cancer cells, even in cell culture models, and these differences do not correlate with cell doubling time.
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Characterization of Phenolic Compounds and Antiproliferative Effects of Salvia pomifera and Salvia fruticosa Extracts
TL;DR: Results demonstrate that these two Salvia species are plants of medicinal interest with perspective for further investigation and provide the first evidence that carnosic acid affects microtubule dynamics and arrests the cell cycle in the G2/M phase.
References
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Microtubules as a target for anticancer drugs.
Mary Ann Jordan,Leslie Wilson +1 more
TL;DR: Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy, and it is now known that at lower concentrations, microtubule-targeted drugs can suppress micro Tubule dynamics without changingmicrotubule mass; this action leads to mitotic block and apoptosis.
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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
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Promotion of microtubule assembly in vitro by taxol
TL;DR: It is reported here that taxol acts as a promoter of calf brain microtubule assembly in vitro, in contrast to plant products such as colchicine and podophyllotoxin, which inhibit assembly.
Journal ArticleDOI
Microtubule-binding agents: a dynamic field of cancer therapeutics
Charles Dumontet,Mary Ann Jordan +1 more
TL;DR: The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties, and the three main objectives are enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms.
Journal Article
Epothilones, a New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action
Daniel M. Bollag,Patricia A. McQueney,Jian Zhu,Otto D. Hensens,Lawrence R. Koupal,Jerrold M. Liesch,Michael A. Goetz,Elias Lazarides,Catherine M. Woods +8 more
TL;DR: Epothilones represent a novel structural class of compounds, the first to be described since the original discovery ofTaxol, which not only mimic the biological effects of taxol but also appear to bind to the same microtubule-binding site as taxol.
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Microtubule-binding agents: a dynamic field of cancer therapeutics
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