Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities
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TLDR
Recent progress in the chemistry and biology of these diverse microtubule stabilizers focusing on the wide range of organisms that produce these compounds, their mechanisms of inhibiting microtubules-dependent processes, mechanisms of drug resistance, and their interactions with tubulin including their distinct binding sites and modes are covered.About:
This article is published in Natural Product Reports.The article was published on 2014-02-11 and is currently open access. It has received 113 citations till now.read more
Citations
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Fluorescent dyes and probes for super-resolution microscopy of microtubules and tracheoles in living cells and tissues
Gražvydas Lukinavičius,Gyuzel Yu. Mitronova,Sebastian Schnorrenberg,Alexey N. Butkevich,Hannah Barthel,Vladimir N. Belov,Stefan W. Hell +6 more
TL;DR: Nanoscopy compatible fluorescent tubulin probes can be used to stain microtubules and chitin-rich taenidia in the insect tracheoles.
Journal ArticleDOI
Tumor‐Targeted Paclitaxel Delivery and Enhanced Penetration Using TAT‐Decorated Liposomes Comprising Redox‐Responsive Poly(Ethylene Glycol)
Han Fu,Kairong Shi,Guanlian Hu,Yuting Yang,Qifang Kuang,Libao Lu,Li Zhang,Wenfei Chen,Mingling Dong,Yantao Chen,Qin He +10 more
TL;DR: C-TAT-LP is a promising tumor-targeting drug carrier that achieved enhanced tumor distribution and demonstrated superior delivery efficiency in vivo and has no obvious drug-related adverse events for liver and heart.
Journal ArticleDOI
Lx2-32c, a novel semi-synthetic taxane, exerts antitumor activity against prostate cancer cells in vitro and in vivo.
Guangyao Lv,Dengjun Sun,Jingwen Zhang,Xiaoxia Xie,Xiaoqiong Wu,Wei-Shuo Fang,Jingwei Tian,Chunhong Yan,Hongbo Wang,Fenghua Fu +9 more
TL;DR: The potential of Lx2-32c as a candidate antitumor agent for the treatment of prostate cancer is demonstrated, with results equivalent to those of docetaxel.
Journal ArticleDOI
Mechanism of microtubule stabilization by taccalonolide AJ.
Yuxi Wang,Yamei Yu,Guo-Bo Li,Shu Ang Li,Chengyong Wu,Benoît Gigant,Wenming Qin,Hao Chen,Yangping Wu,Qiang Chen,Jinliang Yang +10 more
TL;DR: This work proposes that the β-tubulin E-site is locked into a GTP-preferred status by AJ binding, and provides experimental evidence for the connection between MSA binding and tubulin nucleotide state, and will help design new MSAs to overcome taxane resistance.
Journal ArticleDOI
Microtubule-Targeting Drugs: More than Antimitotics.
TL;DR: The role of microtubules in cells, the proliferation paradox of cells in culture as compared to cancers in patients, and evidence that microtubule-targeting drugs inhibit cellular signaling pathways important for tumorigenesis are described.
References
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Microtubules as a target for anticancer drugs.
Mary Ann Jordan,Leslie Wilson +1 more
TL;DR: Highly dynamic mitotic-spindle microtubules are among the most successful targets for anticancer therapy, and it is now known that at lower concentrations, microtubule-targeted drugs can suppress micro Tubule dynamics without changingmicrotubule mass; this action leads to mitotic block and apoptosis.
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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
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Promotion of microtubule assembly in vitro by taxol
TL;DR: It is reported here that taxol acts as a promoter of calf brain microtubule assembly in vitro, in contrast to plant products such as colchicine and podophyllotoxin, which inhibit assembly.
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Microtubule-binding agents: a dynamic field of cancer therapeutics
Charles Dumontet,Mary Ann Jordan +1 more
TL;DR: The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties, and the three main objectives are enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms.
Journal Article
Epothilones, a New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action
Daniel M. Bollag,Patricia A. McQueney,Jian Zhu,Otto D. Hensens,Lawrence R. Koupal,Jerrold M. Liesch,Michael A. Goetz,Elias Lazarides,Catherine M. Woods +8 more
TL;DR: Epothilones represent a novel structural class of compounds, the first to be described since the original discovery ofTaxol, which not only mimic the biological effects of taxol but also appear to bind to the same microtubule-binding site as taxol.
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