Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities
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TLDR
Recent progress in the chemistry and biology of these diverse microtubule stabilizers focusing on the wide range of organisms that produce these compounds, their mechanisms of inhibiting microtubules-dependent processes, mechanisms of drug resistance, and their interactions with tubulin including their distinct binding sites and modes are covered.About:
This article is published in Natural Product Reports.The article was published on 2014-02-11 and is currently open access. It has received 113 citations till now.read more
Citations
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Journal ArticleDOI
Total Synthesis of Amphidinolide K, a Macrolide That Stabilizes F-Actin
Dani Sánchez,Thanos Andreou,Anna M. Costa,Kevin G. Meyer,David R. Williams,Isabel Barasoain,J. Fernando Díaz,Daniel Lucena-Agell,Jaume Vilarrasa +8 more
TL;DR: The total synthesis of (-)-amphidinolide K (1) based on asymmetric addition of allylsilane C1-C8 to enal C9-C22 is reported and behaves as a stabilizer of actin filaments (F-actin) in vitro.
Journal ArticleDOI
A new microtubule-stabilizing agent shows potent antiviral effects against African swine fever virus with no cytotoxicity
Samvel N. Sirakanyan,Erik Arabyan,Astghik Hakobyan,Tamara Hakobyan,Garri Chilingaryan,Harutyun Sahakyan,Arsen Sargsyan,Grigor Arakelov,Karen Nazaryan,Roza Izmailyan,L.O. Abroyan,Zaven A. Karalyan,Elina Arakelova,Elmira K. Hakobyan,Anush A. Hovakimyan,Andre Serobian,Marco Neves,João Sette Whitaker Ferreira,Fernando Ferreira,Hovakim Zakaryan +19 more
TL;DR: In this paper, it has been shown that microtubule-targeted micro-targeting drugs are effective against African swine fever virus (ASFV) for which no effective antiviral drugs are available.
Journal ArticleDOI
SAR Investigation and Discovery of Water-Soluble 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazoles as Potent Tubulin Polymerization Inhibitors.
Ying-Jie Cui,Chao Liu,Chen-Chen Ma,Ya-Ting Ji,Yi-Li Yao,Long-Qian Tang,Cheng-Mei Zhang,Jing-De Wu,Zhao-Peng Liu +8 more
TL;DR: As the hydrochloride salt(s), ID09 and ID33 showed excellent aqueous solubility and favorable Log P value and displayed noteworthily low nanomolar potency against a variety of tumor cells, including those taxol-resistant ones.
Journal ArticleDOI
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization
Romeo Romagnoli,Filippo Prencipe,Paola Oliva,Maria Kimatrai Salvador,Andrea Brancale,Salvatore Ferla,Ernest Hamel,Giampietro Viola,Roberta Bortolozzi,Leentje Persoons,Jan Balzarini,Sandra Liekens,Dominique Schols +12 more
TL;DR: The results presented show that the methoxy substitution and location on the indole nucleus plays an important role in inhibition of cell growth, and the most favorable position for the substituent was at C-6.
Journal Article
Cytoskeletal Proteins in Cancer and Intracellular Stress: A Therapeutic Perspective
Mei Shan Ong,Shuo Deng,Clarissa Esmeralda Halim,Wanpei Cai,Tuan Zea Tan,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,Gautam Sethi,Gautam Sethi,Shing Chuan Hooi,Alan Prem Kumar,Celestial T. Yap,Celestial T. Yap +13 more
TL;DR: In this paper, the cytoskeletal responses to important intracellular stresses (such as mitochondrial, endoplasmic reticulum and oxidative stresses), including effects on oncogenic signalling, are discussed.
References
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Microtubules as a target for anticancer drugs.
Mary Ann Jordan,Leslie Wilson +1 more
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Microtubule-binding agents: a dynamic field of cancer therapeutics
Charles Dumontet,Mary Ann Jordan +1 more
TL;DR: The screening of a range of botanical species and marine organisms has yielded promising new antitubulin agents with novel properties, and the three main objectives are enhanced tumour specificity, reduced neurotoxicity and insensitivity to chemoresistance mechanisms.
Journal Article
Epothilones, a New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action
Daniel M. Bollag,Patricia A. McQueney,Jian Zhu,Otto D. Hensens,Lawrence R. Koupal,Jerrold M. Liesch,Michael A. Goetz,Elias Lazarides,Catherine M. Woods +8 more
TL;DR: Epothilones represent a novel structural class of compounds, the first to be described since the original discovery ofTaxol, which not only mimic the biological effects of taxol but also appear to bind to the same microtubule-binding site as taxol.
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