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Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials
Michael W. Weiner,Dallas P. Veitch,Paul S. Aisen,Laurel A. Beckett,Nigel J. Cairns,Robert C. Green,Danielle J Harvey,Clifford R. Jack,William J. Jagust,John C. Morris,Ronald C. Petersen,Andrew J. Saykin,Leslie M. Shaw,Arthur W. Toga,John Q. Trojanowski,Alzheimer’s Disease Neuroimaging Initiative +15 more
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TLDR
The Alzheimer's Disease Neuroimaging Initiative (ADNI) has continued development and standardization of methodologies for biomarkers and has provided an increased depth and breadth of data available to qualified researchers.About:
The article was published on 2017-04-01 and is currently open access. It has received 169 citations till now. The article focuses on the topics: Alzheimer's Disease Neuroimaging Initiative & Biomarker (medicine).read more
Citations
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Automated classification of Alzheimer's disease and mild cognitive impairment using a single MRI and deep neural networks
Silvia Basaia,Federica Agosta,Luca Wagner,Elisa Canu,Giuseppe Magnani,Roberto Santangelo,Massimo Filippi +6 more
TL;DR: A deep learning algorithm is built and validated predicting the individual diagnosis of Alzheimer's disease and mild cognitive impairment who will convert to AD (c-MCI) based on a single cross-sectional brain structural MRI scan, demonstrating that it is exploitable by not-trained operators and likely to be generalizable to unseen patient data.
Journal ArticleDOI
Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative
Dallas P. Veitch,Michael W. Weiner,Paul S. Aisen,Laurel A. Beckett,Nigel J. Cairns,Robert C. Green,Danielle J Harvey,Clifford R. Jack,William J. Jagust,John C. Morris,Ronald C. Petersen,Andrew J. Saykin,Leslie M. Shaw,Arthur W. Toga,John Q. Trojanowski +14 more
TL;DR: Select topics that provide insights into AD progression are discussed and how this knowledge may improve clinical trials are outlined.
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Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images
TL;DR: This paper proposes a novel deep-learning-based framework to discriminate individuals with AD utilizing a multimodal and multiscale deep neural network and delivers 82.4% accuracy and 94.23% sensitivity in classifying individuals with clinical diagnosis of probable AD.
Journal ArticleDOI
Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.
Kwangsik Nho,Alexandra Kueider-Paisley,Siamak MahmoudianDehkordi,Matthias Arnold,Shannon L. Risacher,Gregory Louie,Colette Blach,Rebecca Baillie,Xianlin Han,Gabi Kastenmüller,Wei Jia,Guoxiang Xie,Shahzad Ahmad,Thomas Hankemeier,Cornelia M. van Duijn,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Andrew J. Saykin,Rima Kaddurah-Daouk +20 more
TL;DR: In this paper, the association of BAs with the "A/T/N" (amyloid, tau, and neurodegeneration) biomarkers for AD: cerebrospinal fluid (CSF), atrophy (magnetic resonance imaging), and brain glucose metabolism (FDG PET).
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Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology
Marc Suárez-Calvet,Marc Suárez-Calvet,Estrella Morenas-Rodríguez,Estrella Morenas-Rodríguez,Gernot Kleinberger,Kai Schlepckow,Miguel Ángel Araque Caballero,Nicolai Franzmeier,Anja Capell,Katrin Fellerer,Brigitte Nuscher,Erden Eren,Erden Eren,Johannes Levin,Johannes Levin,Yuetiva Deming,Laura Piccio,Celeste M. Karch,Carlos Cruchaga,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner,Michael Ewers,Christian Haass,Christian Haass +24 more
TL;DR: CSF sTREM2 increased in early symptomatic stages of late-onset AD but, unexpectedly, was observed decreased at the earliest asymptomatic phase when only abnormal Aβ pathology but no tau pathology or neurodegeneration, is present.
References
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Journal ArticleDOI
Quantifying anatomical shape variations in neurological disorders
Nikhil Singh,P. Thomas Fletcher,J. Samuel Preston,Richard D. King,James Stephen Marron,Michael W. Weiner,Sarang Joshi +6 more
TL;DR: A data-driven global analysis of brain anatomy was able to reach similar conclusions as other studies in Alzheimer's disease based on predefined ROIs, together with the identification of other new patterns of deformation.
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Optimal treatment of Alzheimer’s disease psychosis: challenges and solutions
TL;DR: A review of atypical antipsychotic efficacy in Alzheimer’s disease (AD+P), followed by an overview of critical neurobiological observations that point towards a frontal, tau-mediated model of disease, and a new preclinical animal model for future translational research are suggested.
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Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.
TL;DR: The APOE ε4 allele is associated with accelerated rates of atrophy in 13 distinct brain regions in limbic and neocortical areas, suggesting the possibility of a genotype-specific network of related brain regions that undergo faster atrophyIn MCI and potentially contribute to cognitive decline.
Journal ArticleDOI
Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography.
TL;DR: The results shown here support previous animal studies implicating interactions between these calcium channels in amyloidogenesis and suggest that the pathological cascade of this disease may be modified by interactions in the amyloids–calcium axis.
Journal ArticleDOI
Grey matter atrophy in mild cognitive impairment / early Alzheimer disease associated with delusions: a voxel-based morphometry study.
Windsor Kwan-Chun Ting,Corinne E. Fischer,Colleen Millikin,Zahinoor Ismail,Tiffany W. Chow,Tom A. Schweizer +5 more
TL;DR: Greater right fronto-temporal grey matter atrophy was observed in MCI or early AD participants with delusions compared to matched patients without delusions, consistent with predictions, asymmetric greymatter atrophy in the right hemisphere may contribute to development of delusions through loss of executive inhibition.
Related Papers (5)
2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
Michael W. Weiner,Dallas P. Veitch,Paul S. Aisen,Laurel A. Beckett,Nigel J. Cairns,Jesse M. Cedarbaum,Robert C. Green,Danielle J Harvey,Clifford R. Jack,William J. Jagust,Johan Luthman,John C. Morris,Ronald C. Petersen,Andrew J. Saykin,Leslie M. Shaw,Li Shen,Adam J. Schwarz,Arthur W. Toga,John Q. Trojanowski,Alzheimer’s Disease Neuroimaging Initiative +19 more
Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease.
Dallas P. Veitch,Michael W. Weiner,Paul S. Aisen,Laurel A. Beckett,Charles DeCarli,Robert C. Green,Danielle J Harvey,Clifford R. Jack,William J. Jagust,Susan M. Landau,John C. Morris,Ozioma C. Okonkwo,Richard J. Perrin,Ronald C. Petersen,Monica Rivera-Mindt,Andrew J. Saykin,Leslie M. Shaw,Arthur W. Toga,Duygu Tosun,John Q. Trojanowski,Alzheimer’s Disease Neuroimaging Initiative +20 more