Journal ArticleDOI
Repeated positive fighting experience in male inbred mice
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TLDR
The sensory contact model (SCM) is applied to study repeated aggression in mice and develops pronounced aggressiveness, anxiety and impulsivity, disturbances in motivated and cognitive behaviors, and impairments of sociability.Abstract:
Repeated aggression is a frequent symptom of many psychiatric and neurological disorders, including obsessive-compulsive and attention deficit hyperactivity disorders, bipolar and post-traumatic stress disorders, epilepsy, autism, schizophrenia and drug abuse. However, repeated aggression is insufficiently studied because there is a lack of adequate models in animals. The sensory contact model (SCM), widely used to study the effects of chronic social defeat stress, can also be used to investigate the effects of repeated aggression. Mice with repeated positive fighting experience in daily agonistic interactions in this model develop pronounced aggressiveness, anxiety and impulsivity, disturbances in motivated and cognitive behaviors, and impairments of sociability; they also demonstrate hyperactivity, attention-deficit behavior, motor dysfunctions and repetitive stereotyped behaviors, such as jerks, rotations and head twitches. In this protocol, we describe how to apply the SCM to study repeated aggression in mice. Severe neuropathology develops in male mice after 20-21 d of agonistic interactions.read more
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Animal models of major depression and their clinical implications.
TL;DR: The animal models that are used most commonly for depression, including genetic models, including the recently developed optogenetic tools and the stress models, such as the social stress, chronic mild stress, learned helplessness, and early-life stress paradigms are summarized.
Федеральное государственное бюджетное учреждение «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний» Сибирского отделения Российской академии медицинских наук, Кемерово, Россия
E. N. Usoltseva,Federal State +1 more
TL;DR: In this article, the authors proposed a method to improve the quality of the information provided by the user by using the information from the user's profile and the user profile of the service provider.
Journal ArticleDOI
To Group or Not to Group? Good Practice for Housing Male Laboratory Mice.
TL;DR: It is concluded that whether group- or single-housing is better (or less worse) in any situation is highly context-dependent according to several factors including strain, age, social position, life experiences, and housing and husbandry protocols.
Journal ArticleDOI
Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice.
Yvonne Couch,Alexander Trofimov,Alexander Trofimov,Natalyia Markova,Vladimir N. Nikolenko,Harry W.M. Steinbusch,Vladimir P. Chekhonin,Careen A. Schroeter,Klaus-Peter Lesch,Klaus-Peter Lesch,Daniel C. Anthony,Tatyana Strekalova +11 more
TL;DR: It is evident that when administered independently, both stress and LPS challenges induced distinct molecular and behavioural changes, however, at a time when LPS alone does not induce any overt behavioural changes per se, the combination with stress exacerbates depressive and inhibits aggressive behaviours.
Journal Article
Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice.Couch Y, Trofimov A, Markova N, Nikolenko V, Steinbusch HW, Chekhonin V, Schroeter C, Lesch KP, Anthony DC, Strekalova T
Yvonne Couch,A. Trofimov,Natalyia Markova,Vladimir N. Nikolenko,Harry W.M. Steinbusch,Vladimir P. Chekhonin,Careen A. Schroeter,Klaus-Peter Lesch,Daniel C. Anthony,Tatyana Strekalova +9 more
References
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Reference EntryDOI
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR)
TL;DR: The Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision (DSM-IV-TR) (American Psychiatric Association], 2000) is a compendium of mental disorders, a listing of the criteria used to diagnose them, and a detailed system for their definition, organization, and classification.
Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
Journal ArticleDOI
The use of a plus-maze to measure anxiety in the mouse
TL;DR: The plus-maze appears to be a useful test with which to investigate both anxiolytic and anxiogenic agents.
Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
Journal ArticleDOI
Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions
Vaishnav Krishnan,Ming-Hu Han,Danielle Graham,Olivier Berton,William Renthal,Scott J. Russo,Quincey LaPlant,Ami Graham,Michael Lutter,Diane C. Lagace,Subroto Ghose,Robin Reister,Paul Tannous,Thomas A. Green,Rachael L. Neve,Sumana Chakravarty,Arvind Kumar,Amelia J. Eisch,David W. Self,Francis S. Lee,Carol A. Tamminga,Donald C. Cooper,Howard K. Gershenfeld,Eric J. Nestler +23 more
TL;DR: It is shown that molecular recapitulations of three prototypical adaptations associated with the unsusceptible phenotype are each sufficient to promote resistant behavior and validate a multidisciplinary approach to examine the neurobiological mechanisms of variations in stress resistance.