Retinol binding protein 4: An adipokine associated with intra-amniotic infection/inflammation
Edi Vaisbuch,Shali Mazaki-Tovi,Juan Pedro Kusanovic,Offer Erez,Nandor Gabor Than,Sun Kwon Kim,Zhong Dong,Francesca Gotsch,Pooja Mittal,Tinnakorn Chaiworapongsa,Percy Pacora,Lami Yeo,Sonia S. Hassan,Roberto Romero +13 more
TLDR
The results suggest that RBP4 may participate in the host response against IAI, a physiologic constituent of the AF, among patients with PTL, and the median AF concentration of immunoreactive RBP 4 is elevated in pregnancies complicated by IAI.Abstract:
Objective. Retinol binding protein 4 (RBP4), a specific carrier for retinol in the blood, is a novel adipokine that has been implicated in the pathophysiology of insulin resistance, and its gene expression has been associated with adipose tissue inflammation. Recently, proteomic profiling of amniotic fluid (AF) from women with preterm labor (PTL) revealed over-expression of RBP4 in those who delivered preterm. The aim of this study was to determine whether RBP4 is present in AF, and if its concentrations change with gestational age, in the presence of labor, and intra-amniotic infection/inflammation (IAI) in patients with spontaneous PTL.Study design. This cross-sectional study included pregnant women in the following groups: (1) mid-trimester (n = 30); (2) term not in labor (n = 31); (3) term in labor (n = 30); (4) spontaneous PTL without IAI who delivered at term (n = 60); (5) PTL without IAI who delivered preterm (n = 64); and (6) PTL with IAI (n = 56). RBP4 concentrations in AF were determined by ELIS...read more
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Plasma Retinol-Binding Protein-4 Concentrations Are Elevated in Human Subjects With Impaired Glucose Tolerance and Type 2 Diabetes: Response to Gavi et al.
TL;DR: Plasma RBP4 concentrations were found to be elevated in subjects with IGT or type 2 diabetes and to be related to various clinical parameters known to be associated with insulin resistance.
Journal ArticleDOI
Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia
TL;DR: An overview on the regulation and pathophysiology of leptin and adiponectin in GDM and PE is given and data on novel adipokines including resistin, visfatin, retinol‐binding protein 4 and vaspin are summarized.
Journal ArticleDOI
Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1.
Roberto Romero,Tinnakorn Chaiworapongsa,Zeynep Alpay Savasan,Yi Xu,Youssef Hussein,Zhong Dong,Juan Pedro Kusanovic,Chong Jai Kim,Sonia S. Hassan +8 more
TL;DR: This study determined whether intra-amniotic infection/inflammation (IAI) is associated with changes in amniotic fluid concentrations of HMGB1; and localize immunoreactivity ofHMGB1 in the fetal membranes and umbilical cord of patients with chorioamnionitis.
Journal ArticleDOI
Metabolomics in premature labor: a novel approach to identify patients at risk for preterm delivery.
Roberto Romero,Shali Mazaki-Tovi,Shali Mazaki-Tovi,Edi Vaisbuch,Edi Vaisbuch,Juan Pedro Kusanovic,Juan Pedro Kusanovic,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Ricardo Gomez,Jyh Kae Nien,Bo Hyun Yoon,Moshe Mazor,Jingqin Luo,David Banks,John A. Ryals,Chris Beecher +16 more
TL;DR: Among patients with spontaneous PTL with intact membranes, metabolic profiling of the amniotic fluid can be used to assess the risk of preterm delivery in the presence or absence of infection/inflammation.
Journal ArticleDOI
Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE
Roberto Romero,Tinnakorn Chaiworapongsa,Zeynep Alpay Savasan,Youssef Hussein,Zhong Dong,Juan Pedro Kusanovic,Chong Jai Kim,Sonia S. Hassan +7 more
TL;DR: This finding provides evidence that an alarmin, HMGB1, and one of its receptors, sRAGE, are engaged in the process of clinical chorioamnionitis at term, quite different from those observed in cases of intra-amniotic infection/ inflammation in preterm gestations.
References
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