Journal ArticleDOI
Adipocytokines: mediators linking adipose tissue, inflammation and immunity.
TLDR
Several adipocytokines have a central role in the regulation of insulin resistance, as well as many aspects of inflammation and immunity, and understanding this rapidly growing family of mainly adipocyte-derived mediators might be of importance in the development of new therapies for obesity-associated diseases.Abstract:
There has been much effort recently to define the role of adipocytokines, which are soluble mediators derived mainly from adipocytes (fat cells), in the interaction between adipose tissue, inflammation and immunity. The adipocytokines adiponectin and leptin have emerged as the most abundant adipocyte products, thereby redefining adipose tissue as a key component not only of the endocrine system, but also of the immune system. Indeed, as we discuss here, several adipocytokines have a central role in the regulation of insulin resistance, as well as many aspects of inflammation and immunity. Other adipocytokines, such as visfatin, have only recently been identified. Understanding this rapidly growing family of mainly adipocyte-derived mediators might be of importance in the development of new therapies for obesity-associated diseases.read more
Citations
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Journal ArticleDOI
Adipose Tissue as an Endocrine Organ
Erin E. Kershaw,Jeffrey S. Flier +1 more
TL;DR: An overview of the endocrine functions of adipose tissue can be found in this paper, where the authors highlight the adverse metabolic consequences of both adipose excess and deficiency, and propose a more rational therapy for these increasingly prevalent disorders.
Journal ArticleDOI
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
TL;DR: The 'two-hit' hypothesis is now obsolete, as it is inadequate to explain the several molecular and metabolic changes that take place in NAFLD, and the "multiple hit" hypothesis considers multiple insults acting together on genetically predisposed subjects to induceNAFLD and provides a more accurate explanation of NAFLd pathogenesis.
Journal ArticleDOI
Obesity, inflammation, and insulin resistance.
TL;DR: The rapidly expanding body of animal and clinical data that support potential roles for inflammation in the pathogenesis of insulin resistance and type 2 diabetes mellitus are reviewed.
Journal ArticleDOI
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Tomasz J. Guzik,Nyssa E. Hoch,Kathryn A. Brown,Louise McCann,Ayaz Rahman,Sergey Dikalov,Jörg J. Goronzy,Cornelia M. Weyand,David G. Harrison +8 more
TL;DR: A previously undefined role for T cells in the genesis of hypertension is identified and a role of inflammation in the basis of this prevalent disease isSupporting a novel therapeutic target for the treatment of high blood pressure.
Journal ArticleDOI
Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy
Omry Koren,Julia K. Goodrich,Tyler C. Cullender,Aymé Spor,Kirsi Laitinen,Helene Kling Bäckhed,Antonio Gonzalez,Jeffrey J. Werner,Largus T. Angenent,Rob Knight,Rob Knight,Fredrik Bäckhed,Erika Isolauri,Seppo Salminen,Ruth E. Ley +14 more
TL;DR: It is indicated that host-microbial interactions that impact host metabolism can occur and may be beneficial in pregnancy and when transferred to germ-free mice, T3 microbiota induced greater adiposity and insulin insensitivity compared to T1.
References
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