Journal ArticleDOI
Return to homeostasis: downregulation of NF-κB responses
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TLDR
This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-kB response to prevent inflammation, autoimmune disease and oncogenesis.Abstract:
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.read more
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Saquinavir in steroid-dependent and -resistant nephrotic syndrome: a pilot study
Rosanna Coppo,Roberta Camilla,Porcellini Mg,Licia Peruzzi,Bruno Gianoglio,Alessandro Amore,Valentina Daprà,Elisa Loiacono,Valentina Fonsato,Antonio Dal Canton,Ciro Esposito,Pasquale Esposito,Pier-Angelo Tovo +12 more
TL;DR: In this pilot study, a HIV antiprotease drug reduced proteinuria and had a steroid-sparing effect in some multidrug-resistant/-dependent NS.
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Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2/NF-κB in mouse peritoneal macrophages
TL;DR: The results show that the anti-inflammatory properties of GA potentially result from the inhibition of COX-2, iNOS, IL-6, TNF-α and NO through the down-regulation of RIP2 and NF-κB activation, which impact the development of potential health products for preventing and treating inflammatory diseases.
Journal ArticleDOI
Soluble (pro)renin receptor induces endothelial dysfunction and hypertension in mice with diet-induced obesity via activation of angiotensin II type 1 receptor.
Ziwei Fu,Fei Wang,Xiyang Liu,Jiajia Hu,Jiahui Su,Xiaohan Lu,Aihua Lu,Jae Min Cho,J. David Symons,Chang-Jiang Zou,Tianxin Yang +10 more
TL;DR: In this article, the role of soluble (pro)renin receptor (sPRR), a product of site-1 protease-mediated cleavage of PRR, as a possible ligand of the AT1R in mediating endothelial cell dysfunction in vitro; and arterial dysfunction in mice with diet-induced obesity.
Journal ArticleDOI
A novel mechanism of crosstalk between the p53 and NFκB pathways: MDM2 binds and inhibits p65RelA.
TL;DR: It is reported that the E3 ubiquitin ligase MDM2, whose gene is transcriptionally activated by both NFκB and p53, can bind and inhibit the p65RelA subunit ofNFκB, and can act as a direct negative regulator of NFκBs by binding and inhibiting p65relA.
Journal ArticleDOI
Differential immunomodulatory effects by Tripterygium wilfordii Hook f-derived refined extract PG27 and its purified component PG490 (triptolide) in human peripheral blood T cells: potential therapeutics for arthritis and possible mechanisms explaining in part Chinese herbal theory “Junn-Chenn-Zuou-SS”
TL;DR: PG27, a refined extract from a well-known Chinese antirheumatic herb Tripterygium wilfordii Hook f (TwHf), is effective in attenuating transplantation rejection and extending survival of cardiac xenografts and differential regulatory effects and mechanisms by PG27 and PG490 further support in part a possibly-existing Chinese herbal theory “Junn-Chenn-Zuou-SS”.
References
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Journal ArticleDOI
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
Journal ArticleDOI
Shared principles in NF-kappaB signaling
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: The authors synthesize some of the basic principles that have emerged from studies of NF-kappaB, and aim to generate a more unified view of the regulation of the transcription factor.
Journal ArticleDOI
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
TL;DR: A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels.
Journal ArticleDOI
The Nuclear Factor NF-κB Pathway in Inflammation
TL;DR: How genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway is described.
Journal ArticleDOI
Regulation and Function of NF-κB Transcription Factors in the Immune System
TL;DR: Much progress has been made in the past two years revealing new insights into the regulation and functions of NF-kappaB, and this recent progress is covered in this review.
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