Journal ArticleDOI
Return to homeostasis: downregulation of NF-κB responses
Reads0
Chats0
TLDR
This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-kB response to prevent inflammation, autoimmune disease and oncogenesis.Abstract:
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.read more
Citations
More filters
Journal ArticleDOI
NF-κB, inflammation, immunity and cancer: coming of age
Koji Taniguchi,Michael Karin +1 more
TL;DR: How the initial discovery of a role for NF-κB in linking inflammation and cancer led to an improved understanding of tumour-elicited inflammation and its effects on anticancer immunity is discussed.
Journal ArticleDOI
Inflammation meets cancer, with NF-κB as the matchmaker
Yinon Ben-Neriah,Michael Karin +1 more
TL;DR: Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors.
Journal ArticleDOI
A Cytoplasmic NF-κB Interacting Long Noncoding RNA Blocks IκB Phosphorylation and Suppresses Breast Cancer Metastasis
Bodu Liu,Lijuan Sun,Qiang Liu,Chang Gong,Yandan Yao,Xiao-Bin Lv,Ling Lin,Herui Yao,Fengxi Su,Dangsheng Li,Mu Sheng Zeng,Erwei Song +11 more
TL;DR: This work identifies an NF-KappaB Interacting LncRNA (NKILA), which is upregulated by NF-κB, binds to NF-σκB/IκBs, and directly masks phosphorylation motifs of IKKB, thereby inhibiting IKK-induced IκBosphorylation and NF-kkB activation.
Journal ArticleDOI
Regulation of NF-κB by TNF family cytokines.
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: The authors explored general mechanisms of TNF cytokine signaling, with a focus on the upstream signaling events leading to activation of the so-called canonical and non-canonical NF-κB pathways by TNFR1 and CD40, respectively.
Journal ArticleDOI
Curcumin—From Molecule to Biological Function
TL;DR: This Review describes the development of curcumin from a "traditional" spice and food coloring to a "modern" biological regulator.
References
More filters
Journal ArticleDOI
Cleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-κB Activation
Shaun Rosebeck,Lisa Madden,Xiaohong Jin,Shufang Gu,Ingrid J. Apel,Alex Appert,Rifat Hamoudi,Heidi Noels,Heidi Noels,Xavier Sagaert,Peter Van Loo,Peter Van Loo,Mathijs Baens,Mathijs Baens,Ming-Qing Du,Peter C. Lucas,Linda M. McAllister-Lucas +16 more
TL;DR: This study reveals the gain-of-function proteolytic activity of a fusion oncoprotein and highlights the importance of the noncanonical NF-κB pathway in B lymphoproliferative disease.
Journal ArticleDOI
Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling
TL;DR: It is shown that PKC or T-cell receptor (TCR)/CD28 signaling results in downregulation of Bcl10 protein levels, thereby attenuating NF-κB transcriptional activity, suggesting a new mechanism of negative signaling in which TCR/PKC signaling initially activates B cl10 but later promotes its degradation.
Journal ArticleDOI
Negative Regulation of NF-κB Signaling by PIAS1
Bin Liu,Randy Yang,Kelly A. Wong,Crescent Getman,Natalie Stein,Michael A. Teitell,Genhong Cheng,Hong Wu,Ke Shuai +8 more
TL;DR: It is reported here that PIAS1 (protein inhibitor of activated STAT1) is an important negative regulator of NF-κB, and microarray analysis indicates that the removal ofPIAS1 results in an increased expression of a subset of NF -κB-mediated genes in response to tumor necrosis factor alpha and lipopolysaccharide.
Journal ArticleDOI
Essential role for IκB kinase β in remodeling carma1-bcl10-malt1 complexes upon T cell activation
Elmar Wegener,Andrea Oeckinghaus,Andrea Oeckinghaus,Nikoletta Papadopoulou,Liron Lavitas,Marc Schmidt-Supprian,Uta Ferch,Tak W. Mak,Jürgen Ruland,Vigo Heissmeyer,Daniel Krappmann +10 more
TL;DR: The data provide evidence that IKKbeta serves a dual role upstream of its classical substrates, the IkappaB proteins, while being essential for triggering initial CBM complex formation, IKK beta-dependent phosphorylation of Bcl10 exhibits a negative regulatory role in T cell activation.
Related Papers (5)
Regulation and Function of NF-κB Transcription Factors in the Immune System
NF-kappaB: linking inflammation and immunity to cancer development and progression.
Michael Karin,Florian R. Greten +1 more