Journal ArticleDOI
Return to homeostasis: downregulation of NF-κB responses
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TLDR
This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-kB response to prevent inflammation, autoimmune disease and oncogenesis.Abstract:
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.read more
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IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation
Kidong Kang,Minho Won,Jae-Min Yuk,Chan Yong Park,Hee Sun Byun,Kyeong Ah Park,So-Ra Lee,Young-Goo Kang,Han-Ming Shen,Ill Young Lee,Gang Min Hur +10 more
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Functional analysis of pattern recognition receptors in miniature dachshunds with inflammatory colorectal polyps.
Hirotaka Igarashi,Koichi Ohno,Aki Fujiwara-Igarashi,Hideyuki Kanemoto,Kenjiro Fukushima,Yuko Goto-Koshino,Kazuyuki Uchida,Hajime Tsujimoto +7 more
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SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation
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LPS-Inducible lncRNA TMC3-AS1 Negatively Regulates the Expression of IL-10
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References
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
Journal ArticleDOI
Shared principles in NF-kappaB signaling
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: The authors synthesize some of the basic principles that have emerged from studies of NF-kappaB, and aim to generate a more unified view of the regulation of the transcription factor.
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NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
TL;DR: A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels.
Journal ArticleDOI
The Nuclear Factor NF-κB Pathway in Inflammation
TL;DR: How genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway is described.
Journal ArticleDOI
Regulation and Function of NF-κB Transcription Factors in the Immune System
TL;DR: Much progress has been made in the past two years revealing new insights into the regulation and functions of NF-kappaB, and this recent progress is covered in this review.
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