Journal ArticleDOI
Return to homeostasis: downregulation of NF-κB responses
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TLDR
This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-kB response to prevent inflammation, autoimmune disease and oncogenesis.Abstract:
Activation of NF-κB transcription factors by receptors of the innate or adaptive immune system is essential for host defense. However, after danger is eliminated, NF-κB signaling needs to be tightly downregulated for the maintenance of tissue homeostasis. This review highlights key negative regulatory principles that affect the amount, localization or conformational properties of NF-κB-activating proteins to attenuate the NF-κB response. These mechanisms are needed to prevent inflammation, autoimmune disease and oncogenesis.read more
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The Extrusion Process as an Alternative for Improving the Biological Potential of Sorghum Bran: Phenolic Compounds and Antiradical and Anti-Inflammatory Capacity
Norma J. Salazar López,Guadalupe Loarca-Piña,Rocio Campos-Vega,Marcela Co-Asesor: Gaytan Martinez,Eduardo Morales Sánchez,J. Marina Esquerra-Brauer,Gustavo A. González-Aguilar,Maribel Robles Sánchez +7 more
TL;DR: The results suggest that extruded sorghum bran could be used as a functional ingredient and provide advantages to consumers by reducing diseases related to oxidative stress and inflammation.
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Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling
TL;DR: A series of structurally simplified cryptocaryone analogues synthesized by a facile Pd-catalyzed acetoxylation of alkyne-tethered cyclohexadienones constitute a promising new scaffold for the development of novel NF-κB inhibitors and anticancer agents.
Journal ArticleDOI
Dietary zinc and the control of Streptococcus pneumoniae infection
Bart A. Eijkelkamp,Jacqueline R. Morey,Stephanie L. Neville,Stephanie L. Neville,Aimee Tan,Victoria G. Pederick,Nerida Cole,Nerida Cole,Prashina P. Singh,Cheryl-lynn Y. Ong,Raquel Gonzalez de Vega,David Clases,Bliss A. Cunningham,Catherine E. Hughes,Iain Comerford,Erin B. Brazel,Jonathan J. Whittall,Charles D. Plumptre,Shaun R. McColl,James C. Paton,Alastair G. McEwan,Philip Doble,Christopher A. McDevitt,Christopher A. McDevitt +23 more
TL;DR: Dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences, which is shown to be highly sensitive to zinc intoxication.
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Identification of LPS-Activated Endothelial Subpopulations With Distinct Inflammatory Phenotypes and Regulatory Signaling Mechanisms
Erna-Zulaikha Dayang,Josee A. Plantinga,Bram M. ter Ellen,Matijs van Meurs,Grietje Molema,Jill Moser +5 more
TL;DR: It is suggested that LPS activates different signaling mechanisms in EC that drive heterogeneous expression of EC inflammatory molecules and further characterization of the signaling pathways involved will enhance the understanding of endothelial heterogeneous responses to sepsis related stimuli.
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Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells.
Su Ui Lee,Min Hee Sung,Hyung Won Ryu,Jinhyuk Lee,Hui-Seong Kim,Hyun Ju In,Kyung-Seop Ahn,Hyun-Jun Lee,Hyeong-Kyu Lee,Dae-Hee Shin,Yongnam Lee,Sung-Tae Hong,Sei-Ryang Oh +12 more
TL;DR: Results suggest that verproside could be a good therapeutic candidate for treatment of inflammatory airway diseases such as asthma and COPD by blocking the TNF-α/NF-κB signaling pathway.
References
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Journal ArticleDOI
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
Journal ArticleDOI
Shared principles in NF-kappaB signaling
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: The authors synthesize some of the basic principles that have emerged from studies of NF-kappaB, and aim to generate a more unified view of the regulation of the transcription factor.
Journal ArticleDOI
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
TL;DR: A role is proposed for miR-146 in control of Toll-like receptor and cytokine signaling through a negative feedback regulation loop involving down-regulation of IL-1 receptor-associated kinase 1 and TNF receptor- associated factor 6 protein levels.
Journal ArticleDOI
The Nuclear Factor NF-κB Pathway in Inflammation
TL;DR: How genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway is described.
Journal ArticleDOI
Regulation and Function of NF-κB Transcription Factors in the Immune System
TL;DR: Much progress has been made in the past two years revealing new insights into the regulation and functions of NF-kappaB, and this recent progress is covered in this review.
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