Journal ArticleDOI
Risk Factors for Progression of Low-Grade Dysplasia in Patients With Barrett's Esophagus
Sachin Wani,Gary W. Falk,Jane Post,Lisa Yerian,Matthew Hall,Amy Wang,Neil Gupta,Srinivas Gaddam,Mandeep Singh,Vikas Singh,Keng-Yu Chuang,Vikram Boolchand,Hemanth Gavini,John Kuczynski,Priti Sud,Ajay Bansal,Amit Rastogi,Sharad C. Mathur,Patrick E. Young,Brooks D. Cash,John R. Goldblum,David A. Lieberman,Richard E. Sampliner,Prateek Sharma +23 more
TLDR
Overall, patients with BE and LGD have a low annual incidence of EAC, similar to nondysplastic BE, and there is significant interobserver variation in diagnosis, even among expert pathologists.About:
This article is published in Gastroenterology.The article was published on 2011-10-01. It has received 243 citations till now.read more
Citations
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Journal ArticleDOI
Photodynamic therapy vs radiofrequency ablation for Barrett's dysplasia: efficacy, safety and cost-comparison.
TL;DR: In the authors' experience, RFA had higher rate of CR-D without any serious adverse events and was less costly than PDT for endoscopic treatment of Barrett's dysplasia.
Journal ArticleDOI
Progression of Barrett oesophagus: role of endoscopic and histological predictors
TL;DR: Until molecular biomarkers are identified and validated as adjunctive tools for risk Stratification, knowledge of endoscopic features could complement dysplasia grading for risk stratification of patients with Barrett oesophagus and identify subgroups at risk of progression to OAC.
Journal ArticleDOI
Dysplasia in Barrett's oesophagus: p53 immunostaining is more reproducible than haematoxylin and eosin diagnosis and improves overall reliability, while grading is poorly reproducible
Philip Kaye,Mohammad Ilyas,Irshad Soomro,Syeda A Haider,Gurprit Atwal,Sindhu Menon,Shafiq Gill,Cathy Richards,Rebecca Harrison,Kevin West,Krish Ragunath +10 more
TL;DR: This study compared the reliability of p53 and dysplasia interpretation and grading to determine its generalizability to routine practice.
Journal ArticleDOI
Assessment of a custom-built Raman spectroscopic probe for diagnosis of early oesophageal neoplasia.
L. Max Almond,Jo Hutchings,Catherine Kendall,John C. Day,Oliver A C Stevens,Gavin R. Lloyd,Neil A. Shepherd,Hugh Barr,Nicholas Stone +8 more
TL;DR: The Raman probe system can provide rapid, objective, and accurate diagnosis of oesophageal pathology ex vivo and enables superficial mucosal abnormalities (metaplasia and dysplasia) to be classified in clinically applicable timescales paving the way for an in vivo trial.
Journal ArticleDOI
A Tissue Systems Pathology Assay for High-Risk Barrett's Esophagus
Rebecca J. Critchley-Thorne,Lucas C. Duits,Jeffrey W. Prichard,Jon M. Davison,Blair A. Jobe,Bruce B. Campbell,Yi Zhang,Kathleen A. Repa,Lia M Reese,Jinhong Li,David L. Diehl,Nirag Jhala,Gregory G. Ginsberg,Maureen DeMarshall,Tyler Foxwell,Ali H. Zaidi,D. Lansing Taylor,Anil K. Rustgi,Jacques J. Bergman,Gary W. Falk +19 more
TL;DR: A tissue systems pathology test is developed that better predicts risk of progression in Barrett's esophagus than clinicopathologic variables and has the potential to improve upon histologic analysis as an objective method to risk stratify Barrett's Esophagus patients.
References
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Journal ArticleDOI
Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus.
TL;DR: The guidelines for the diagnosis, surveillance and therapy of Barrett’s esophagus were originally published by the American College of Gastroenterology in 1998 and updated in 2002 and once again reviewed using the National Library of Medicine database.
Journal ArticleDOI
The Vienna classification of gastrointestinal epithelial neoplasia
Ronald J. Schlemper,Robert H. Riddell,Yo Kato,F Borchard,Harry S. Cooper,Sanford M. Dawsey,Michael F. Dixon,C M Fenoglio-Preiser,Jean-François Fléjou,Karel Geboes,Takanori Hattori,T Hirota,Masayuki Itabashi,Mitsuya Iwafuchi,Akinori Iwashita,Y I Kim,Thomas Kirchner,M Klimpfinger,Morio Koike,Gregory Y. Lauwers,Klaus J. Lewin,Georg Oberhuber,Felix Offner,A B Price,Carlos A. Rubio,M Shimizu,Tadakazu Shimoda,Pentti Sipponen,Enrico Solcia,M Stolte,Hiroshi Watanabe,Hirohiko Yamabe +31 more
TL;DR: The differences between Western and Japanese pathologists in the diagnostic classification of gastrointestinal epithelial neoplastic lesions can be resolved largely by adopting the proposed terminology, which is based on cytological and architectural severity and invasion status.
Journal ArticleDOI
Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
Robert H. Riddell,Harvey Goldman,David F. Ransohoff,Henry D. Appelman,Cecilia M. Fenoglio,Rodger C. Haggitt,Christer hren,Pelayo Correa,Stanley R. Hamilton,B C Morson,Sheldon C. Sommers,John H. Yardley +11 more
TL;DR: A classification system for the epithelial changes that occur in ulcerative colitis was developed, which should be applicable to other forms of inflammatory bowel disease as well and makes use of standardized terminology, addresses specific problem areas, and offers practical solutions.
Journal ArticleDOI
Radiofrequency Ablation in Barrett's Esophagus with Dysplasia
Nicholas J. Shaheen,Prateek Sharma,Bergein F. Overholt,Herbert C. Wolfsen,Richard E. Sampliner,Kenneth K. Wang,Joseph A. Galanko,Mary P. Bronner,John R. Goldblum,Ana E. Bennett,Blair A. Jobe,Glenn M. Eisen,M. Brian Fennerty,John G. Hunter,David E. Fleischer,Virender K. Sharma,Robert H. Hawes,Brenda J. Hoffman,Richard I. Rothstein,Stuart R. Gordon,Hiroshi Mashimo,Kenneth J. Chang,V. Raman Muthusamy,Steven A. Edmundowicz,Stuart J. Spechler,Ali A. Siddiqui,Rhonda F. Souza,Anthony Infantolino,Gary W. Falk,Michael B. Kimmey,Ryan D. Madanick,Amitabh Chak,Charles J. Lightdale +32 more
TL;DR: In patients with dysplastic Barrett's esophagus, radiofrequency ablation was associated with a high rate of complete eradication of both dysplasia and intestinal metaplasia, and a reduced risk of disease progression.
Journal ArticleDOI
The Role of Overdiagnosis and Reclassification in the Marked Increase of Esophageal Adenocarcinoma Incidence
Heiko Pohl,H. Gilbert Welch +1 more
TL;DR: The rising incidence of esophageal adenocarcinoma represents a real increase in disease burden and overdiagnosis can be excluded as an explanation for the rise in incidence.
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