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Journal ArticleDOI

Risk Factors for Progression of Low-Grade Dysplasia in Patients With Barrett's Esophagus

TLDR
Overall, patients with BE and LGD have a low annual incidence of EAC, similar to nondysplastic BE, and there is significant interobserver variation in diagnosis, even among expert pathologists.
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This article is published in Gastroenterology.The article was published on 2011-10-01. It has received 243 citations till now.

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Journal ArticleDOI

Acid-suppressive medications and risk of oesophageal adenocarcinoma in patients with Barrett's oesophagus: a systematic review and meta-analysis

TL;DR: Based on meta-analysis of observational studies, the use of PPIs is associated with a decreased risk of OAC and/or BO-HGD in patients with Barrett's oesophagus, and PPI use should be considered in BO.
Journal ArticleDOI

Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus

TL;DR: Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with BO and appears to be a more powerful predictor of neoperastic progression than histological diagnosis of low-grade dysplasia.
Journal ArticleDOI

The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry

TL;DR: It has become apparent that the cardinal feature of achalasia, impaired lower esophageal sphincter relaxation, can occur in several disease phenotypes; however, without a disease-specific biomarker, no manometric pattern is absolutely specific.
Journal ArticleDOI

Epidemiology of Barrett’s Esophagus and Esophageal Adenocarcinoma

TL;DR: Factors predicting progression from nondysplastic BE to EAC include dysplastic changes on esophageal histology and length of the involved BE segment.
References
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Journal ArticleDOI

Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus.

TL;DR: The guidelines for the diagnosis, surveillance and therapy of Barrett’s esophagus were originally published by the American College of Gastroenterology in 1998 and updated in 2002 and once again reviewed using the National Library of Medicine database.
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The Vienna classification of gastrointestinal epithelial neoplasia

TL;DR: The differences between Western and Japanese pathologists in the diagnostic classification of gastrointestinal epithelial neoplastic lesions can be resolved largely by adopting the proposed terminology, which is based on cytological and architectural severity and invasion status.
Journal ArticleDOI

Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications

TL;DR: A classification system for the epithelial changes that occur in ulcerative colitis was developed, which should be applicable to other forms of inflammatory bowel disease as well and makes use of standardized terminology, addresses specific problem areas, and offers practical solutions.
Journal ArticleDOI

The Role of Overdiagnosis and Reclassification in the Marked Increase of Esophageal Adenocarcinoma Incidence

TL;DR: The rising incidence of esophageal adenocarcinoma represents a real increase in disease burden and overdiagnosis can be excluded as an explanation for the rise in incidence.
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