Journal ArticleDOI
Risk Factors for Progression of Low-Grade Dysplasia in Patients With Barrett's Esophagus
Sachin Wani,Gary W. Falk,Jane Post,Lisa Yerian,Matthew Hall,Amy Wang,Neil Gupta,Srinivas Gaddam,Mandeep Singh,Vikas Singh,Keng-Yu Chuang,Vikram Boolchand,Hemanth Gavini,John Kuczynski,Priti Sud,Ajay Bansal,Amit Rastogi,Sharad C. Mathur,Patrick E. Young,Brooks D. Cash,John R. Goldblum,David A. Lieberman,Richard E. Sampliner,Prateek Sharma +23 more
TLDR
Overall, patients with BE and LGD have a low annual incidence of EAC, similar to nondysplastic BE, and there is significant interobserver variation in diagnosis, even among expert pathologists.About:
This article is published in Gastroenterology.The article was published on 2011-10-01. It has received 243 citations till now.read more
Citations
More filters
Journal ArticleDOI
Predictors of Progression to High-Grade Dysplasia or Adenocarcinoma in Barrett's Esophagus.
Matthew J. Whitson,Gary W. Falk +1 more
TL;DR: Both risk and protective factors for neoplastic progression in patients with Barrett's esophagus are reviewed.
Journal ArticleDOI
A Cost-Effectiveness Analysis Of An Adenocarcinoma Risk Prediction Multi-Biomarker Assay For Patients With Barrett's Esophagus.
TL;DR: Given the model assumptions, the new Assay would be cost-effective after 5 years and improves patient outcomes due to improvement in the effectiveness of surveillance and treatment protocols resulting in fewer patients progressing to HGD and EAC and fewer EAC-related deaths.
Journal ArticleDOI
Goblet Cell Ratio in Combination with Differentiation and Stem Cell Markers in Barrett Esophagus Allow Distinction of Patients with and without Esophageal Adenocarcinoma
Raphael Schellnegger,Anne S. Quante,Susanne Rospleszcz,Martina Schernhammer,Bettina Höhl,Moritz Tobiasch,Agniezska Pastula,Anna Brandtner,Julian A. Abrams,Konstantin Strauch,Roland M. Schmid,Michael Vieth,Timothy C. Wang,Michael Quante +13 more
TL;DR: The primary goal was to distinguish patients with Barrett esophagus with no evidence of dysplasia from those with Dysplasia, and the goblet cell ratio, rather than the presence ofGoblet cells per se, was found to be an important discriminator.
Journal ArticleDOI
Development and Validation of Confocal Endomicroscopy Diagnostic Criteria for Low-Grade Dysplasia in Barrett's Esophagus.
Massimiliano di Pietro,Helga Bertani,Maria O'Donovan,Patricia Santos,Hani Alastal,Hani Alastal,Richard J. Phillips,Jacobo Ortiz-Fernández-Sordo,Marietta Iacucci,Ines Modolell,Luca Reggiani Bonetti,Krish Ragunath,Lorenz Wernisch +12 more
TL;DR: Using pCLE criteria for LGD in BE, pCLE diagnosis of LGD is reproducible and has a substantial interobserver agreement.
Journal ArticleDOI
Diagnosis and Management of Barrett’s Esophagus
TL;DR: Recommendations for the management of subjects diagnosed with Barrett esophagus include periodic endoscopic surveillance to detect the development of high-grade dysplasia or adenocarcinoma.
References
More filters
Journal ArticleDOI
Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus.
TL;DR: The guidelines for the diagnosis, surveillance and therapy of Barrett’s esophagus were originally published by the American College of Gastroenterology in 1998 and updated in 2002 and once again reviewed using the National Library of Medicine database.
Journal ArticleDOI
The Vienna classification of gastrointestinal epithelial neoplasia
Ronald J. Schlemper,Robert H. Riddell,Yo Kato,F Borchard,Harry S. Cooper,Sanford M. Dawsey,Michael F. Dixon,C M Fenoglio-Preiser,Jean-François Fléjou,Karel Geboes,Takanori Hattori,T Hirota,Masayuki Itabashi,Mitsuya Iwafuchi,Akinori Iwashita,Y I Kim,Thomas Kirchner,M Klimpfinger,Morio Koike,Gregory Y. Lauwers,Klaus J. Lewin,Georg Oberhuber,Felix Offner,A B Price,Carlos A. Rubio,M Shimizu,Tadakazu Shimoda,Pentti Sipponen,Enrico Solcia,M Stolte,Hiroshi Watanabe,Hirohiko Yamabe +31 more
TL;DR: The differences between Western and Japanese pathologists in the diagnostic classification of gastrointestinal epithelial neoplastic lesions can be resolved largely by adopting the proposed terminology, which is based on cytological and architectural severity and invasion status.
Journal ArticleDOI
Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications
Robert H. Riddell,Harvey Goldman,David F. Ransohoff,Henry D. Appelman,Cecilia M. Fenoglio,Rodger C. Haggitt,Christer hren,Pelayo Correa,Stanley R. Hamilton,B C Morson,Sheldon C. Sommers,John H. Yardley +11 more
TL;DR: A classification system for the epithelial changes that occur in ulcerative colitis was developed, which should be applicable to other forms of inflammatory bowel disease as well and makes use of standardized terminology, addresses specific problem areas, and offers practical solutions.
Journal ArticleDOI
Radiofrequency Ablation in Barrett's Esophagus with Dysplasia
Nicholas J. Shaheen,Prateek Sharma,Bergein F. Overholt,Herbert C. Wolfsen,Richard E. Sampliner,Kenneth K. Wang,Joseph A. Galanko,Mary P. Bronner,John R. Goldblum,Ana E. Bennett,Blair A. Jobe,Glenn M. Eisen,M. Brian Fennerty,John G. Hunter,David E. Fleischer,Virender K. Sharma,Robert H. Hawes,Brenda J. Hoffman,Richard I. Rothstein,Stuart R. Gordon,Hiroshi Mashimo,Kenneth J. Chang,V. Raman Muthusamy,Steven A. Edmundowicz,Stuart J. Spechler,Ali A. Siddiqui,Rhonda F. Souza,Anthony Infantolino,Gary W. Falk,Michael B. Kimmey,Ryan D. Madanick,Amitabh Chak,Charles J. Lightdale +32 more
TL;DR: In patients with dysplastic Barrett's esophagus, radiofrequency ablation was associated with a high rate of complete eradication of both dysplasia and intestinal metaplasia, and a reduced risk of disease progression.
Journal ArticleDOI
The Role of Overdiagnosis and Reclassification in the Marked Increase of Esophageal Adenocarcinoma Incidence
Heiko Pohl,H. Gilbert Welch +1 more
TL;DR: The rising incidence of esophageal adenocarcinoma represents a real increase in disease burden and overdiagnosis can be excluded as an explanation for the rise in incidence.
Related Papers (5)
Radiofrequency Ablation in Barrett's Esophagus with Dysplasia
Nicholas J. Shaheen,Prateek Sharma,Bergein F. Overholt,Herbert C. Wolfsen,Richard E. Sampliner,Kenneth K. Wang,Joseph A. Galanko,Mary P. Bronner,John R. Goldblum,Ana E. Bennett,Blair A. Jobe,Glenn M. Eisen,M. Brian Fennerty,John G. Hunter,David E. Fleischer,Virender K. Sharma,Robert H. Hawes,Brenda J. Hoffman,Richard I. Rothstein,Stuart R. Gordon,Hiroshi Mashimo,Kenneth J. Chang,V. Raman Muthusamy,Steven A. Edmundowicz,Stuart J. Spechler,Ali A. Siddiqui,Rhonda F. Souza,Anthony Infantolino,Gary W. Falk,Michael B. Kimmey,Ryan D. Madanick,Amitabh Chak,Charles J. Lightdale +32 more