Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation.
Tatsu Tanabe,Tatsu Tanabe,Hironosuke Watanabe,Jigesh A. Shah,Hisashi Sahara,Hisashi Sahara,Akira Shimizu,Shunichiro Nomura,A. Asfour,Makenzie Danton,Lennan K Boyd,A. Dardenne Meyers,Dilrukshi Ekanayake-Alper,David H. Sachs,David H. Sachs,Kazuhiko Yamada,Kazuhiko Yamada +16 more
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TLDR
The results suggest that intrinsic factors are responsible, at least in part, for growth of donor organs and that this property should be taken into consideration for growth‐curve–mismatched transplants, especially for life‐supporting organs transplanted into a limited recipient space.About:
This article is published in American Journal of Transplantation.The article was published on 2017-07-01 and is currently open access. It has received 82 citations till now. The article focuses on the topics: Miniature swine.read more
Citations
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Consistent success in life-supporting porcine cardiac xenotransplantation
Matthias Längin,Tanja Mayr,Bruno Reichart,Sebastian Michel,Stefan Buchholz,Sonja Guethoff,Alexey Dashkevich,Andrea Baehr,Stefanie Egerer,Andreas Bauer,Maks Mihalj,Alessandro Panelli,Lara Issl,Jiawei Ying,Ann Kathrin Fresch,Ines Buttgereit,Maren Mokelke,Julia Radan,Fabian Werner,I. Lutzmann,Stig Steen,Trygve Sjöberg,Audrius Paskevicius,Liao Qiuming,Riccardo Sfriso,Robert Rieben,Maik Dahlhoff,Barbara Kessler,Elisabeth Kemter,Mayuko Kurome,Valeri Zakhartchenko,Katharina Klett,Katharina Klett,Rabea Hinkel,Rabea Hinkel,Christian Kupatt,Almuth Falkenau,Simone Reu,Reinhard Ellgass,Rudolf Herzog,Uli Binder,Günter Wich,Arne Skerra,David Ayares,Alexander Kind,Uwe Schönmann,Franz-Josef Kaup,Christian Hagl,Eckhard Wolf,Nikolai Klymiuk,Paolo Brenner,Jan-Michael Abicht +51 more
TL;DR: It is shown that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model.
Journal ArticleDOI
Transplanting organs from pigs to humans.
Megan Sykes,David H. Sachs +1 more
TL;DR: The potential and limitations of modifications of pigs genetically and how the engineering of the graft can be leveraged to alter the host immune response so that all types of immune attack are avoided are discussed.
Journal ArticleDOI
Does size matter
TL;DR: The size of the transplants may influence the survival time of xenotransplants in nonhuman primates and the use of minipigs or pigs with mutations in the gene of the growth hormone receptor 17 may overcome these problems.
Journal ArticleDOI
Xenotransplantation: past, present, and future.
TL;DR: The field is getting ready for clinical trials with an international consensus with convincing preclinical data from many centers, and the next decade will show new achievements and additional barriers in clinical xenotransplantation.
Journal ArticleDOI
Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals
TL;DR: The data indicate that PERVs were not transmitted because they were not released from the transplant or were inhibited by intracellular restriction factors and innate immunity in the recipient.
References
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Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
Kazuhiko Yamada,Koji Yazawa,Akira Shimizu,Takehiro Iwanaga,Yosuke Hisashi,M Nuhn,Patricia J. O'Malley,Shuji Nobori,Parsia A. Vagefi,Clive Patience,Jay A. Fishman,David K. C. Cooper,Robert J. Hawley,Julia L. Greenstein,Henk Jan Schuurman,Michel Awwad,Megan Sykes,David H. Sachs +17 more
TL;DR: Life-supporting pig-to-baboon renal xenograft survivals of up to 83 d with normal creatinine levels are achieved using α-1,3-galactosyltransferase knockout donors and a tolerance induction approach.
Journal ArticleDOI
Monitoring lymphocyte proliferation in vitro and in vivo with the intracellular fluorescent dye carboxyfluorescein diacetate succinimidyl ester.
TL;DR: This protocol outlines the carboxyfluorescein diacetate succinimidyl ester (CFSE) method for following the proliferation of human and mouse lymphocytes both in vitro and in vivo, finding that division-dependent changes in the expression of cell-surface markers and intracellular proteins are easily quantified by flow cytometry.
Journal ArticleDOI
Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice
Tetsuo Shioi,Julie R. McMullen,Peter M. Kang,Pamela S. Douglas,Toshiyuki Obata,Toshiyuki Obata,Thomas F. Franke,Lewis C. Cantley,Lewis C. Cantley,Seigo Izumo +9 more
TL;DR: Akt is sufficient to induce a marked increase in heart size and is likely to be one of the effectors of the PI3K pathway in mediating heart growth.
Journal ArticleDOI
Transplantation in miniature swine. I. Fixation of the major histocompatibility complex.
David H. Sachs,George S. Leight,James L. Cone,Susan L. Schwarz,Leonard D. Stuart,Steven A. Rosenberg +5 more
TL;DR: Three strains of miniature swine, each homozygous for a different allele of the major histocompatibility locus (MHC), have been developed by a selective breeding scheme based on tissue typing of the offspring of each generation, confirming the homology between the MHC of these miniature Swine and those of man and mouse.
Journal ArticleDOI
One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
TL;DR: The pig is an important livestock for food supply and an ideal model for various human diseases and the complex design and generation of ZFNs and TALENs, as well as the technical challenges of SCNT, greatly limit the application of this method.
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Marked prolongation of porcine renal xenograft survival in baboons through the use of α1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
Consistent success in life-supporting porcine cardiac xenotransplantation
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